Results 51 to 60 of about 19,187 (211)

Methylated BNIP3 gene in colorectal cancer prognosis

Oncology Letters, 2010
The DNA methylation of apoptosis-related genes in various cancers contributes to the disruption of the apoptotic pathway and results in resistance to chemotherapeutic agents. Irinotecan (CPT-11) is one of the key chemotherapy drugs used to treat metastatic colorectal cancer (CRC).
Sayaka, Shimizu, Satoru, Iida, Megumi, Ishiguro, Hiroyuki, Uetake, Toshiaki, Ishikawa, Yoko, Takagi, Hirotoshi, Kobayashi, Tetsuro, Higuchi, Masayuki, Enomoto, Kaoru, Mogushi, Hiroshi, Mizushima, Hiroshi, Tanaka, Kenichi, Sugihara   +12 more
openaire   +3 more sources

Expression and Functional Characterization of the BNIP3 Protein in Renal Cell Carcinomas

Translational Oncology, 2017
BNIP3 (Bcl-2/adenovirus E1B 19-kDa interacting protein 3) is a BH3-only protein that regulates apoptosis and autophagy. BNIP3 plays also an important role in hypoxia-induced cell response and is regulated by HIF1.
Stephan Macher-Goeppinger, Martina Keith, Gencay Hatiboglu, Markus Hohenfellner, Peter Schirmacher, Wilfried Roth, Katrin E. Tagscherer   +6 more
doaj   +1 more source

A key role for leukemia inhibitory factor in C26 cancer cachexia [PDF]

, 2015
Cachexia is an exacerbating event in many types of cancer that is strongly associated with a poor prognosis. We have identified cytokine, signaling, and transcription factors that are required for cachexia in the mouse C26 colon carcinoma model of cancer.
Jackman, Robert W., Kandarian, Susan C., Seto, Danielle N.   +2 more
core   +1 more source

Myocardial Dysfunction in an Animal Model of Cancer Cachexia [PDF]

, 2011
Aims Fatigue is a common occurrence in cancer patients regardless of tumor type or anti-tumor therapies and is an especially problematic symptom in persons with incurable tumor disease.
Crawford, Danielle, Hutchinson, Kirk R., Lucchesi, Pamela A., McCarthy, Donna O., Velten, Markus, Wold, Loren E., Xu, Hui, Youtz, Dane J.   +7 more
core   +2 more sources

Nuclear localization of the mitochondrial factor HIGD1A during metabolic stress. [PDF]

, 2013
Cellular stress responses are frequently governed by the subcellular localization of critical effector proteins. Apoptosis-inducing Factor (AIF) or Glyceraldehyde 3-Phosphate Dehydrogenase (GAPDH), for example, can translocate from mitochondria to the ...
Aghi, Manish, Ameri, Kurosh, Choi, Hwa J, Delay, Michael, Donne, Matthew, Jahangiri, Arman, Jeffrey, Stefanie S, Maltepe, Emin, Nguyen, Vien, Rajah, Anthony M, Rinaudo, Paolo F, Rowitch, David H, Sanders, Timothy A, Tormos, Kathryn V, Yeghiazarians, Yerem   +14 more
core   +2 more sources

Expression of BNIP3 in invasive breast cancer: correlations with the hypoxic response and clinicopathological features

BMC Cancer, 2009
Background Bcl-2/adenovirus E1B 19 kDa-interacting protein 3 (BNIP3) is a pro-apoptotic member of the Bcl-2 family induced under hypoxia. Low or absent expression has recently been described in human tumors, including gastrointestinal tumors, resulting ...
de Weger Roel A, van Wichen Dick F, van Laar Theo, Koop Esther A, Wall Elsken, van Diest Paul J   +5 more
doaj   +1 more source

The ER membrane protein complex restricts mitophagy by controlling BNIP3 turnover

The EMBO Journal, 2023
Lysosomal degradation of autophagy receptors is a common proxy for selective autophagy. However, we find that two established mitophagy receptors, BNIP3 and BNIP3L/NIX, are constitutively delivered to lysosomes in an autophagy-independent manner.
Jose M Delgado, Logan Wallace Shepard, Sarah W Lamson, Samantha L Liu, Christopher J Shoemaker   +4 more
doaj   +1 more source

The pharmacological regulation of cellular mitophagy [PDF]

, 2017
Small molecules are pharmacological tools of considerable value for dissecting complex biological processes and identifying potential therapeutic interventions.
A Brunet, A Cassidy-Stone, A Hoshino, A Hoshino, A Jain, A Kazlauskaite, A Khaminets, A Managò, A Orvedahl, A Sargsyan, A Schiavi, AE Alekseev, AT Dinkova-Kostova, AY Amerik, B Arun, B Bingol, B Maro, BJ Gurd, BM Kenwood, BS Padman, C Jo, C Jo, C Kondapalli, C Zhang, CA da Costa, CN Cunningham, CT Chu, D Liu, D Narendra, D Narendra, DA East, DA East, DP Narendra, EA Liberman, EF Fang, EH Kim, EH Kim, F Gao, F Ivanes, G Ashrafi, G Bellot, G Chen, G Wells, Geoff Wells, GFG Allen, GL McLelland, H Jia, H Sandoval, H Wei, H Zhang, HC Bertrand, HT Kang, I Kim, I Novak, IH Lee, J Gatliff, J Gatliff, J H Zhu, J Li, J Viotti, J Yun, J-H Zhu, JR Jangamreddy, K Grenier, K-S Park, KKK Chung, KM Holmström, L Liu, M Frank, M Fu, M Lazarou, M Mauro-Lizcano, M Mogi, M Redmann, Michelangelo Campanella, MV Tsiper, NA Khan, ND Georgakopoulos, Nikolaos D Georgakopoulos, NT Hertz, NV Kirienko, P Bai, Q Shen, R Huang, R Rupprecht, RD Sentelle, RJ Youle, RK Dagda, S Givvimani, S Kume, S Melser, S Rikka, SA Hasson, SJ Park, SM Jin, SY Jang, TM Durcan, W Duan, W Yue, X Qi, Y Kageyama, Y Wang, YP Yang, YQ Liu   +103 more
core   +4 more sources

Misoprostol treatment prevents hypoxia-induced cardiac dysfunction through a 14-3-3 and PKA regulatory motif on Bnip3

Cell Death and Disease, 2021
Systemic hypoxia is a common element in most perinatal emergencies and is a known driver of Bnip3 expression in the neonatal heart. Bnip3 plays a prominent role in the evolution of necrotic cell death, disrupting ER calcium homeostasis and initiating ...
Matthew D. Martens, Nivedita Seshadri, Lucas Nguyen, Donald Chapman, Elizabeth S. Henson, Bo Xiang, Landon Falk, Arielys Mendoza, Sunil Rattan, Jared T. Field, Philip Kawalec, Spencer B. Gibson, Richard Keijzer, Ayesha Saleem, Grant M. Hatch, Christine A. Doucette, Jason M. Karch, Vernon W. Dolinsky, Ian M. Dixon, Adrian R. West, Christof Rampitsch, Joseph W. Gordon   +21 more
doaj   +1 more source

BNip3 regulates mitochondrial function and lipid metabolism in the liver [PDF]

, 2012
BNip3 localizes to the outer mitochondrial membrane, where it functions in mitophagy and mitochondrial dynamics. While the BNip3 protein is constitutively expressed in adult liver from fed mice, we have shown that its expression is superinduced by ...
Beaton, Michelle, Brady, Matthew J, Dorn, Gerald W, II, Glick, Danielle, Gruber, Michaela, Hart, John, Macleod, Kay F, Marsboom, Glenn, Simon, M. Celeste, Zhang, Wenshuo   +9 more
core   +2 more sources