Results 51 to 60 of about 21,955 (252)

Challenges of drug resistance in the management of pancreatic cancer [PDF]

, 2010
The current treatment of choice for metastatic pancreatic cancer involves single agent gemcitabine or combination of gemcitabine with capecitabine and erlotinib (tyrosine kinase inhibitor).
Akada, Allison, Almoguera, Andreetta, Arai, Arlt, Arteaga, Arumugam, Asano, Bachem, Baldwin, Banerjee, Bartsch, Bergers, Best, Bold, Bondar, Buck, Burris, Chakravarti, Chakravarti, Choi, Cunningham, Cunningham, Dancer, Dong, Duxbury, Duxbury, Duxbury, Duxbury, Engelman, Feldmann, Ferrero, Galmarini, Geyer, Giovannetti, Goan, Greer, Hagmann, Hahn, Henke, Hruban, Humeniuk, Ischenko, Ishikawa, Itoi, Jansen, Karapetis, Kindler, Kong, Koopman, Kulik, Lei, Lemoine, Liau, Liau, Longley, Mackey, Mackey, Mackey, Mahon, Mamaghani, Marechal, Marmor, Martin Clynes, Mata, Maxwell, Mendelsohn, Meropol, Miwa, Moertel, Molina-Arcas, Moore, Morgillo, Moriyama, Muerkoster, Muerkoster, Nakahira, Nakajima, Nakano, Naomi Walsh, Nishimura, Oguri, Okamoto, Okumura, Olive, O’Driscoll, Pao, Park, Park, Peters, Plunkett, Ray McDermott, Ritzel, Rizwan Sheikh, Robert O’Connor, Ruggeri, Safran, Saito, Sakamoto, Schuller, Sebastiani, Shah, Shi, Simon, Spratlin, Takao, Takebayashi, Treat, Tsukamoto, Tzeng, Vaishampayan, Van Cutsem, van der Wilt, Wang, Wang, Wang, Xiong, Yamasaki, Yokoi   +119 more
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Bnip3 impairs mitochondrial bioenergetics and stimulates mitochondrial turnover [PDF]

Cell Death & Differentiation, 2010
Bnip3 (Bcl-2/adenovirus E1B 19-kDa-interacting protein 3) is a mitochondrial BH3-only protein that contributes to cell death through activation of the mitochondrial pathway of apoptosis. Bnip3 is also known to induce autophagy, but the functional role of autophagy is unclear.
S, Rikka, M N, Quinsay, R L, Thomas, D A, Kubli, X, Zhang, A N, Murphy, Å B, Gustafsson   +6 more
openaire   +2 more sources

Bnip3 Binds and Activates p300: Possible Role in Cardiac Transcription and Myocyte Morphology.

PLoS ONE, 2015
Bnip3 is a hypoxia-regulated member of the Bcl-2 family of proteins that is implicated in apoptosis, programmed necrosis, autophagy and mitophagy. Mitochondria are thought to be the primary targets of Bnip3 although its activities may extend to the ER ...
John W Thompson, Jianqin Wei, Kweku Appau, Huilan Wang, Hong Yu, Maria G Spiga, Regina M Graham, Keith A Webster   +7 more
doaj   +1 more source

Expression and Functional Characterization of the BNIP3 Protein in Renal Cell Carcinomas

Translational Oncology, 2017
BNIP3 (Bcl-2/adenovirus E1B 19-kDa interacting protein 3) is a BH3-only protein that regulates apoptosis and autophagy. BNIP3 plays also an important role in hypoxia-induced cell response and is regulated by HIF1.
Stephan Macher-Goeppinger, Martina Keith, Gencay Hatiboglu, Markus Hohenfellner, Peter Schirmacher, Wilfried Roth, Katrin E. Tagscherer   +6 more
doaj   +1 more source

A crosstalk between phosphorylation and ubiquitination of BNIP3 regulates mitophagy under hypoxia

Autophagy Reports, 2023
BNIP3 (BCL2/adenovirus e1B 19 kDa protein interacting protein 3) is a mitochondrial outer membrane protein that is sensitive to hypoxia and mediates mitophagy, a process important for mitochondrial quality control and to maintain energetic and redox ...
Yun-Ling He, Jian Li, Yan Cao, Hai-Tao Wu, Li-Ying Wu   +4 more
doaj   +1 more source

Dexmedetomidine post-treatment attenuates cardiac ischaemia/reperfusion injury by inhibiting apoptosis through HIF-1α signalling. [PDF]

, 2020
Hypoxia-inducible factor 1α (HIF-1α) plays a critical role in the apoptotic process during cardiac ischaemia/reperfusion (I/R) injury. This study aimed to investigate whether post-treatment with dexmedetomidine (DEX) could protect against I/R-induced ...
Chen, Wei-Rong, Ji, Fu-Hai, Liu, Hong, Liu, Hua-Yue, Meng, Xiao-Wen, Peng, Ke, Xia, Fan, Xia, Zheng-Yuan, Zhang, Juan   +8 more
core  

Nuclear localization of the mitochondrial factor HIGD1A during metabolic stress. [PDF]

, 2013
Cellular stress responses are frequently governed by the subcellular localization of critical effector proteins. Apoptosis-inducing Factor (AIF) or Glyceraldehyde 3-Phosphate Dehydrogenase (GAPDH), for example, can translocate from mitochondria to the ...
Aghi, Manish, Ameri, Kurosh, Choi, Hwa J, Delay, Michael, Donne, Matthew, Jahangiri, Arman, Jeffrey, Stefanie S, Maltepe, Emin, Nguyen, Vien, Rajah, Anthony M, Rinaudo, Paolo F, Rowitch, David H, Sanders, Timothy A, Tormos, Kathryn V, Yeghiazarians, Yerem   +14 more
core   +2 more sources

Methylated BNIP3 gene in colorectal cancer prognosis

Oncology Letters, 2010
The DNA methylation of apoptosis-related genes in various cancers contributes to the disruption of the apoptotic pathway and results in resistance to chemotherapeutic agents. Irinotecan (CPT-11) is one of the key chemotherapy drugs used to treat metastatic colorectal cancer (CRC).
Sayaka, Shimizu, Satoru, Iida, Megumi, Ishiguro, Hiroyuki, Uetake, Toshiaki, Ishikawa, Yoko, Takagi, Hirotoshi, Kobayashi, Tetsuro, Higuchi, Masayuki, Enomoto, Kaoru, Mogushi, Hiroshi, Mizushima, Hiroshi, Tanaka, Kenichi, Sugihara   +12 more
openaire   +3 more sources

BNIP3 Upregulation Characterizes Cancer Cell Subpopulation With Increased Fitness and Proliferation

Frontiers in Oncology, 2022
BNIP3 is a BH3-only protein with both pro-apoptotic and pro-survival roles depending on the cellular context. It remains unclear how BNIP3 RNA level dictates cell fate decisions of cancer cells.
Yanyan Zhu, Bowang Chen, Bowang Chen, Junya Yan, Wendi Zhao, Pengli Dou, Na Sun, Yaokai Wang, Xiaoyun Huang, Xiaoyun Huang   +9 more
doaj   +1 more source

Myocardial Dysfunction in an Animal Model of Cancer Cachexia [PDF]

, 2011
Aims Fatigue is a common occurrence in cancer patients regardless of tumor type or anti-tumor therapies and is an especially problematic symptom in persons with incurable tumor disease.
Crawford, Danielle, Hutchinson, Kirk R., Lucchesi, Pamela A., McCarthy, Donna O., Velten, Markus, Wold, Loren E., Xu, Hui, Youtz, Dane J.   +7 more
core   +2 more sources