Results 61 to 70 of about 21,955 (252)

Differentiation state-specific mitochondrial dynamic regulatory networks are revealed by global transcriptional analysis of the developing chicken lens. [PDF]

, 2014
The mature eye lens contains a surface layer of epithelial cells called the lens epithelium that requires a functional mitochondrial population to maintain the homeostasis and transparency of the entire lens.
Anastas, Sara, Basu, Subhasree, Brennan, Lisa A., Chauss, Daniel, Gau, Victoria, Hejtmancik, J. Fielding, Kantorow, Marc, Ma, Zhiwei, Menko, A. Sue, Rajakaruna, Suren   +9 more
core   +3 more sources

The pharmacological regulation of cellular mitophagy [PDF]

, 2017
Small molecules are pharmacological tools of considerable value for dissecting complex biological processes and identifying potential therapeutic interventions.
A Brunet, A Cassidy-Stone, A Hoshino, A Hoshino, A Jain, A Kazlauskaite, A Khaminets, A Managò, A Orvedahl, A Sargsyan, A Schiavi, AE Alekseev, AT Dinkova-Kostova, AY Amerik, B Arun, B Bingol, B Maro, BJ Gurd, BM Kenwood, BS Padman, C Jo, C Jo, C Kondapalli, C Zhang, CA da Costa, CN Cunningham, CT Chu, D Liu, D Narendra, D Narendra, DA East, DA East, DP Narendra, EA Liberman, EF Fang, EH Kim, EH Kim, F Gao, F Ivanes, G Ashrafi, G Bellot, G Chen, G Wells, Geoff Wells, GFG Allen, GL McLelland, H Jia, H Sandoval, H Wei, H Zhang, HC Bertrand, HT Kang, I Kim, I Novak, IH Lee, J Gatliff, J Gatliff, J H Zhu, J Li, J Viotti, J Yun, J-H Zhu, JR Jangamreddy, K Grenier, K-S Park, KKK Chung, KM Holmström, L Liu, M Frank, M Fu, M Lazarou, M Mauro-Lizcano, M Mogi, M Redmann, Michelangelo Campanella, MV Tsiper, NA Khan, ND Georgakopoulos, Nikolaos D Georgakopoulos, NT Hertz, NV Kirienko, P Bai, Q Shen, R Huang, R Rupprecht, RD Sentelle, RJ Youle, RK Dagda, S Givvimani, S Kume, S Melser, S Rikka, SA Hasson, SJ Park, SM Jin, SY Jang, TM Durcan, W Duan, W Yue, X Qi, Y Kageyama, Y Wang, YP Yang, YQ Liu   +103 more
core   +4 more sources

Hypoxia‐Preconditioned BMSC‐Derived Exosomes Induce Mitophagy via the BNIP3–ANAX2 Axis to Alleviate Intervertebral Disc Degeneration

Advancement of science
Intervertebral disc degeneration (IVDD) is a chronic degenerative disease involving the aging and loss of proliferative capacity of nucleus pulposus cells (NPCs), processes heavily dependent on mitochondrial dynamics and autophagic flux. This study finds
Yuxin Jin, Ouqiang Wu, Qizhu Chen, Linjie Chen, Zhiguang Zhang, Haijun Tian, Hao Zhou, Kai Zhang, Jianyuan Gao, Xinzhou Wang, Zhenyu Guo, Jing Sun, K. Kwan, Morgan Jones, Yan Michael Li, E. Zare, Pooyan Makvandi, Xiangyang Wang, Shuying Shen, Aimin Wu   +19 more
semanticscholar   +1 more source

A mitophagy sensor PPTC7 controls BNIP3 and NIX degradation to regulate mitochondrial mass.

Molecules and Cells, 2023
Mitophagy mediated by BNIP3 and NIX critically regulates mitochondrial mass. Cellular BNIP3 and NIX levels are tightly controlled by SCFFBXL4-mediated ubiquitination to prevent excessive mitochondrial loss and lethal disease.
Yuqiu Sun, Yu Cao, Huayun Wan, Adalet Memetimin, Yang Cao, Lin Li, Chongyang Wu, Meng Wang, She Chen, Qi Li, Yan Ma, Meng-qiu Dong, Hui Jiang   +12 more
semanticscholar   +1 more source

The ER membrane protein complex restricts mitophagy by controlling BNIP3 turnover

The EMBO Journal, 2023
Lysosomal degradation of autophagy receptors is a common proxy for selective autophagy. However, we find that two established mitophagy receptors, BNIP3 and BNIP3L/NIX, are constitutively delivered to lysosomes in an autophagy-independent manner.
Jose M Delgado, Logan Wallace Shepard, Sarah W Lamson, Samantha L Liu, Christopher J Shoemaker   +4 more
doaj   +1 more source

A key role for leukemia inhibitory factor in C26 cancer cachexia [PDF]

, 2015
Cachexia is an exacerbating event in many types of cancer that is strongly associated with a poor prognosis. We have identified cytokine, signaling, and transcription factors that are required for cachexia in the mouse C26 colon carcinoma model of cancer.
Jackman, Robert W., Kandarian, Susan C., Seto, Danielle N.   +2 more
core   +1 more source

Dahuang chuanxiong decoction against contrast-induced nephropathy: Multi-omics, crosstalk between BNIP3-mediated mitophagy and IL-17 pathway.

Phytomedicine
BACKGROUND Contrast-induced nephropathy (CIN), also known as contrast-induced acute kidney injury (CI-AKI), represents a prevalent form of hospital-acquired renal injury. However, the mechanisms underlying its pathogenesis remain unclear.
Zhiyong Song, Jun Li, Xuezhong Gong
semanticscholar   +1 more source

Silencing of NAMPT leads to up-regulation of insulin receptor substrate 1 gene expression in U87 glioma cells

Endocrine Regulations, 2020
Objective. The aim of the present study was to investigate the effect of adipokine NAMPT (nicotinamide phosphoribosyltransferase) silencing on the expression of genes encoding IRS1 (insulin receptor substrate 1) and some other proliferation related ...
Tsymbal Daria O., Minchenko Dmytro O., Luzina Olena Y., Riabovol Olena O., Danilovskyi Serhiy V., Minchenko Oleksandr H.   +5 more
doaj   +1 more source

Misoprostol treatment prevents hypoxia-induced cardiac dysfunction through a 14-3-3 and PKA regulatory motif on Bnip3

Cell Death and Disease, 2021
Systemic hypoxia is a common element in most perinatal emergencies and is a known driver of Bnip3 expression in the neonatal heart. Bnip3 plays a prominent role in the evolution of necrotic cell death, disrupting ER calcium homeostasis and initiating ...
Matthew D. Martens, Nivedita Seshadri, Lucas Nguyen, Donald Chapman, Elizabeth S. Henson, Bo Xiang, Landon Falk, Arielys Mendoza, Sunil Rattan, Jared T. Field, Philip Kawalec, Spencer B. Gibson, Richard Keijzer, Ayesha Saleem, Grant M. Hatch, Christine A. Doucette, Jason M. Karch, Vernon W. Dolinsky, Ian M. Dixon, Adrian R. West, Christof Rampitsch, Joseph W. Gordon   +21 more
doaj   +1 more source

BNip3 regulates mitochondrial function and lipid metabolism in the liver [PDF]

, 2012
BNip3 localizes to the outer mitochondrial membrane, where it functions in mitophagy and mitochondrial dynamics. While the BNip3 protein is constitutively expressed in adult liver from fed mice, we have shown that its expression is superinduced by ...
Beaton, Michelle, Brady, Matthew J, Dorn, Gerald W, II, Glick, Danielle, Gruber, Michaela, Hart, John, Macleod, Kay F, Marsboom, Glenn, Simon, M. Celeste, Zhang, Wenshuo   +9 more
core   +2 more sources