Results 71 to 80 of about 21,955 (252)

The role of lipid metabolism in neuronal senescence

FEBS Open Bio, EarlyView.
Disrupted lipid metabolism, through alterations in lipid species or lipid droplet accumulation, can drive neuronal senescence. However, lipid dyshomeostasis can also occur alongside neuronal senescence, further amplifying tissue damage. Delineating how lipid‐induced senescence emerges in neurons and glial cells, and how it contributes to ageing and ...
Dikaia Tsagkari, Eleftheria Panagiotidou, Nektarios Tavernarakis   +2 more
wiley   +1 more source

Receptor proteins in selective autophagy [PDF]

, 2012
Autophagy has long been thought to be an essential but unselective bulk degradation pathway. However, increasing evidence suggests selective autophagosomal turnover of a broad range of substrates.
Behrends, Christian, Fulda, Simone
core   +1 more source

Regulation of BNIP3 in Normal and Cancer Cells

Molecules and Cells, 2006
Bcl-2/adenovirus E1B 19 kDa-interacting protein 3 (BNIP3) is a mitochondrial pro-apoptotic protein that has a single Bcl-2 homology 3 (BH3) domain and a COOH-terminal transmembrane (TM) domain. Al-though it belongs to the Bcl-2 family and can hetero-dimerize with Bcl-2, its pro-apoptotic activity is distinct from those of other members of the Bcl-2 ...
Hayyoung, Lee, Sang-Gi, Paik
openaire   +2 more sources

Swelling‐Programmed Topographical Guidance for Dynamic Spheroid Self‐Assembly via a Mechanochemical Hydrogel Niche

Advanced Functional Materials, EarlyView.
A swelling‐programmed micropatterned hydrogel guides adherent cells through a controlled transition from cell–matrix anchoring to cadherin‐mediated cell–cell compaction, enabling rapid assembly of high‐viability spheroids with defined size and morphology.
Han Gyeol Nam, Seon Yeong Chae, Young Woo Kwon, Hye Jin Heo, Hye Rin Lee, Ji Hyeok Lee, Dong‐Wook Han, Yun Hak Kim, Suck Won Hong   +8 more
wiley   +1 more source

Activation of BNIP3-mediated mitophagy protects against renal ischemia-reperfusion injury [PDF]

, 2019
Acute kidney injury (AKI) is a syndrome of abrupt loss of renal functions. The underlying pathological mechanisms of AKI remain largely unknown. BCL2-interacting protein 3 (BNIP3) has dual functions of regulating cell death and mitophagy, but its ...
Cai, Juan, Chen, Guochun, Dong, Zheng, Han, Hailong, He, Liyu, Liu, Yu, Liu, Yuxue, Liu, Zhiwen, Tang, Chengyuan, Yin, Lijun, Yin, Xiao-Ming, Zhang, Zhuohua   +11 more
core   +1 more source

Regulation of apoptosis by a Caenorhabditis elegans BNIP3 homolog [PDF]

Oncogene, 1998
We have identified a C. elegans protein, ceBNIP3, homologous to the human BCL-2/EIB-19K interacting BCL-2 family pro-apoptotic protein BNIP3. In transiently transfected mammalian cells, ceBNIP3 complexes with CED-9, the worm homolog of BCL-2. CeBNIP3 also efficiently heterodimerizes with the cell death protease proCED-3 by direct binding via the ...
M, Yasuda, C, D'Sa-Eipper, X L, Gong, G, Chinnadurai   +3 more
openaire   +2 more sources

Targeting Lactate and Lactylation in Cancer Metabolism and Immunotherapy

Advanced Science, EarlyView.
Lactate, once deemed a metabolic waste, emerges as a central regulator of cancer progression. This review elucidates how lactate and its epigenetic derivative, protein lactylation, orchestrate tumor metabolism, immune suppression, and therapeutic resistance.
Jiajing Gong, Yuhang Xie, Zhijie Weng, Yongzhi Wu, Longjiang Li, Bo Li   +5 more
wiley   +1 more source

Hypoxia-inducible factor-1 (HIF-1) pathway activation by quercetin in human lens epithelial cells [PDF]

, 2009
Quercetin is a dietary bioflavonoid which has been shown to inhibit lens opacification in a number of models of cataract. The objectives of this study were to determine gene expression changes in human lens epithelial cells in response to quercetin and ...
Beyer-Mears, Castilla, Daub, Dery, Eady, Ferrara, Formica, Gilbert, Gong, Hains, Hanneken, Hertog, Hertog, Hollman, Jacques, Jeon, Jeong, Jeremy D. Rhodes, Julie Sanderson, Kampkotter, Klein, Klein, Knekt, Knekt, Lamson, Leopoldini, Leung, Li, Lija, Listgarten, Livak, Maiese, Manach, Park, Paul A. Kroon, Pauline Radreau, Reddan, Rice-Evans, Richard F. Mithen, Ridley, Sanderson, Sanderson, Schofield, Semenza, Semenza, Semenza, Shui, Shui, Shui, Spector, Tavani, Taylor, Triantafyllou, Triantafyllou, Truscott, Vandesompele, Wang, Wilson, Wormstone   +58 more
core   +1 more source

BNIP3 in Lung Cancer: To Kill or Rescue? [PDF]

Cancers, 2020
Bcl-2/adenovirus E1B 19kDa interacting protein 3 (BNIP3) is a pro-apoptotic BH3-only protein of the Bcl-2 family. Initially, BNIP3 was described as one of the mediators of hypoxia-induced apoptotic cell death in cardiac myocytes and neurons. Besides apoptosis, BNIP3 plays a crucial role in autophagy, metabolic pathways, and metastasis-related processes
Anna S. Gorbunova, Maria A. Yapryntseva, Tatiana V. Denisenko, Boris Zhivotovsky   +3 more
openaire   +2 more sources

Integrative Approaches to Treating Cellular Senescence in Kidney Disease

Advanced Science, EarlyView.
ABSTRACT Cellular senescence in the kidney plays a crucial role in the progression of acute kidney injury and chronic kidney disease. Therapeutic approaches targeting senescent cells, such as small molecule senolytic and senomorphic drugs, display efficacy in preclinical models.
Tomoka Misawa, Amruta A, LaTonya J. Hickson, Joy Wolfram   +3 more
wiley   +1 more source