Results 81 to 90 of about 19,187 (211)

BNIP3 expression in bovine follicle and corpus luteum

Journal of Veterinary Medical Science, 2018
BNIP3 (BCL2/adenovirus E1B nineteen kilodalton interacting protein-3), a member of the BCL2 family, is activated under hypoxic conditions and induces apoptosis or mitochondrial autophagy for adapting cells to hypoxia. The physiological roles of BNIP3 in the mammalian ovary are still unclear. In order to understand the role of BNIP3 in the bovine ovary,
NISHIMURA, Ryo, OKUDA, Kiyoshi, GUNJI, Yosuke, KHALID, Ahmed Magzoub, YAMANO, Yoshiaki, YAMASHITA, Yasuhisa, HISHINUMA, Mitsugu   +6 more
openaire   +2 more sources

Hypoxia-inducible factor-1 (HIF-1) pathway activation by quercetin in human lens epithelial cells [PDF]

, 2009
Quercetin is a dietary bioflavonoid which has been shown to inhibit lens opacification in a number of models of cataract. The objectives of this study were to determine gene expression changes in human lens epithelial cells in response to quercetin and ...
Beyer-Mears, Castilla, Daub, Dery, Eady, Ferrara, Formica, Gilbert, Gong, Hains, Hanneken, Hertog, Hertog, Hollman, Jacques, Jeon, Jeong, Jeremy D. Rhodes, Julie Sanderson, Kampkotter, Klein, Klein, Knekt, Knekt, Lamson, Leopoldini, Leung, Li, Lija, Listgarten, Livak, Maiese, Manach, Park, Paul A. Kroon, Pauline Radreau, Reddan, Rice-Evans, Richard F. Mithen, Ridley, Sanderson, Sanderson, Schofield, Semenza, Semenza, Semenza, Shui, Shui, Shui, Spector, Tavani, Taylor, Triantafyllou, Triantafyllou, Truscott, Vandesompele, Wang, Wilson, Wormstone   +58 more
core   +1 more source

Muscle wasting in cancer cachexia: Mechanisms and the role of exercise

Experimental Physiology, EarlyView.
Abstract Cancer cachexia (CC) is a multifactorial disease marked by a severe and progressive loss of lean muscle mass and characterized further by inflammation and a negative energy/protein balance, ultimately leading to muscle atrophy and loss of muscle tissue.
Zoe P. Libramento, Louisa Tichy, Traci L. Parry   +2 more
wiley   +1 more source

Testosterone induces renal tubular epithelial cell death through the HIF-1α/BNIP3 pathway

Journal of Translational Medicine, 2019
Background The morbidity of nephrolithiasis is 2–3 times higher in males than in females, suggesting that androgen plays a key role in nephrolithiasis.
Yonghan Peng, Ziyu Fang, Min Liu, Zeyu Wang, Ling Li, Shaoxiong Ming, Chaoyue Lu, Hao Dong, Wenhui Zhang, Qi Wang, Rong Shen, Fei Xie, Weitao Zhang, Cheng Yang, Xiaofeng Gao, Yinghao Sun   +15 more
doaj   +1 more source

The Aging Heart: Mitophagy at the Center of Rejuvenation. [PDF]

, 2020
Aging is associated with structural and functional changes in the heart and is a major risk factor in developing cardiovascular disease. Many recent studies have focused on increasing our understanding of the basis of aging at the cellular and molecular ...
Gustafsson, Åsa B, Liang, Wenjing J
core   +1 more source

A Rab5 endosomal pathway mediates Parkin-dependent mitochondrial clearance [PDF]

, 2017
Damaged mitochondria pose a lethal threat to cells that necessitates their prompt removal. The currently recognized mechanism for disposal of mitochondria is autophagy, where damaged organelles are marked for disposal via ubiquitylation by Parkin.
A Choudhury, A Hamacher-Brady, A Hoshino, A Kirchhofer, A Kuma, A Marchese, A Roczniak-Ferguson, A Zeigerer, AH Gaspar, C Campsteijn, C Raiborg, CH Davis, CS Zhang, D Narendra, DA Kubli, DA Kubli, DA Kubli, DC Rubinsztein, DJ Yamashiro, E Karwatowska-Prokopczuk, F Kanai, FR Maxfield, G Gong, G Twig, GL McLelland, GL McLelland, IH Lee, J Rink, JR Kremer, K Hayashida, K Hirosako, K Okatsu, KY Kim, M Komatsu, M Kundu, M Matsui, M Song, M Song, N Hariharan, NC McKnight, PA Ney, Q Sun, R Sahu, R Zoncu, RA Hanna, RN Day, S Geisler, S Hwang, S Jean, S Kaushik, S Phan, SG Roy, SJ Martin, SR Sriram, SR Yoshii, SS Lam, T Kitada, TD Cummins, TD Schmittgen, V Soubannier, WM Henne, WW Li, WX Ding, XM Liu, Y Chen, Y Nishida, Y Zhang, YR Chen   +67 more
core   +2 more sources

One day of environment‐induced heat stress causes injury to the murine kidney

Experimental Physiology, EarlyView.
Abstract Environment‐induced heat stress (EIHS) results from sustained body temperature elevation owing to prolonged exposure to heat and humidity. We hypothesized that EIHS would cause kidney injury and cellular dysfunction. To test this hypothesis, female C57 mice were exposed to EIHS (n = 14; 37.6°C, 42.0% relative humidity) or thermoneutral (TN ...
Melissa Roths, Alyona Michael, Zachary J. Schlader, Joshua T. Selsby   +3 more
wiley   +1 more source

HIF-1 alpha-independent hypoxia-induced rapid PTK6 stabilization is associated with increased motility and invasion [PDF]

, 2014
© 2014 Landes Bioscience. PTK6/Brk is a non-receptor tyrosine kinase overexpressed in cancer. Here we demonstrate that cytosolic PTK6 is rapidly and robustly induced in response to hypoxic conditions in a HIF-1-independent manner.
Blokland, Nina J. G., Broos, Agnieke W. T., Eccles, Suzanne A., Hammond, Ester M., Harvey, Amanda J., Pires, Isabel M., Poujade, Flore-Anne, Senra, Joana M., Span, Paul N.   +8 more
core   +1 more source

Mitophagy in skeletal muscle: Impact of ageing, exercise and disuse

Experimental Physiology, EarlyView.
Abstract Skeletal muscle plays an important role in whole‐body health, quality of life and regulation of metabolism. The maintenance of a healthy mitochondrial pool is imperative for the preservation of skeletal muscle quality and is mediated through mitochondrial quality control consisting of mitochondrial turnover mediated by a balance between ...
Anastasiya Kuznyetsova, David A. Hood
wiley   +1 more source

Sphingosine kinase 2 activates autophagy and protects neurons against ischemic injury through interaction with Bcl-2 via its putative BH3 domain [PDF]

, 2017
Our previous findings suggest that sphingosine kinase 2 (SPK2) mediates ischemic tolerance and autophagy in cerebral preconditioning. The aim of this study was to determine by which mechanism SPK2 activates autophagy in neural cells.
Chen, Jia-Li, Qin, Zheng-Hong, Sheng, Rui, Song, Dan-Dan, Waeber, Christian, Xia, Yun-Fei, Zhang, Tong-Tong   +6 more
core   +1 more source