Results 51 to 60 of about 88,042,096 (284)
Indian Journal of Plastic Surgery, 2015 Background: The bone morphogenetic protein (BMP) signalling pathway is crucial in a number of developmental processes and is critical in the formation of variety of craniofacial elements including cranial neural crest, facial primordium, tooth, lip and ...
Sathyaprasad Savitha +3 more
doaj +1 more source
IGF2 knockout reduces but does not abolish osteosarcoma growth in vitro and in vivo
FEBS Open Bio, EarlyView.To test whether endogenous IGF2 promotes osteosarcoma growth, IGF2 was knocked out in Saos2 cells via CRISPR‐Cas9. KO cells showed reduced proliferation in vitro, and knockout xenografts in mice reached only ~25% of wild‐type tumor volume. Insulin‐like growth factor 2 (IGF2) is implicated in osteosarcoma, but direct functional evidence of its role is ...
Shun Yao, Marco Archetti
wiley +1 more source
Bone morphogenetic protein‐4 expression in the adult rat brain
Journal of Comparative Neurology, 2006 AbstractBone morphogenetic protein‐4 (BMP4) is a member of the transforming growth factor‐β (TGF‐β) superfamily and plays important roles in multiple biological events. Although BMP4 expression has been well described in the early development of the central nervous system (CNS), little information is available on its expression in the adult CNS ...
Sumiko, Mikawa, Cong, Wang, Kohji, Sato
openaire +2 more sources
Cloning of rat type I receptor cDNA for bone morphogenetic protein‐2 and bone morphogenetic protein‐4, and the localization compared with that of the ligands [PDF]
Developmental Dynamics, 1996 A rat homologue cDNA of mouse (Koenig et al. [1994] Mol. Cell Biol. 14:5961-5974; Suzuki et al. [1994] Proc. Natl. Acad. Sci. USA 91: 10255-10259) and human (ten Dijke et al. [1994] J. Biol. Chem. 269:16985-16988) type I receptors for BMP-2 and BMP-4 was cloned. Tissue distribution of the receptor mRNA was studied by in situ hybridization using rats at
T, Ikeda +6 more
openaire +2 more sources
, 2009 Background: Tissue-engineered solutions for promoting the tendon graft incorporation within the bone tunnel appear to be promising. Hypothesis: To determine the feasibility that conjugation of hyaluronic acid-tethered bone morphogenetic protein-2 can be ...
CHEN, CHIH-HWA;LIU, HSIA-WEI;TSAI, CHING-LIN;YU, CHUNG-MING;HSIUE, GING-HO +1 more
core +1 more source
Hybrid Biofabrication of a Hierarchically Organized Periosteum‐Inspired In Vitro Platform
Advanced Healthcare Materials, EarlyView.A hybrid biofabrication strategy integrates melt electrowriting with extrusion‐based 3D bioprinting to create a hierarchically organized periosteum‐inspired in vitro platform. Spatially defined osteogenic, fibrous, and endothelial cell‐containing compartments support long‐term culture, osteogenic maturation, and CD31+ endothelial cell organization ...
Yakui Liu +7 more
wiley +1 more source
Advanced Materials Interfaces, EarlyView.Graphene layers are fabricated on Cu foil and transferred onto glass substrates to form double‐ and multi‐layer G‐glass. Raman spectroscopy confirms structural integrity, while SEM and fluorescence microscopy reveal favorable adhesion and spreading of L‐929 fibroblast cells.
Mariana Mihaela Apostol +8 more
wiley +1 more source
Hepatology, EarlyView., 2022 Hepatic endothelial Alk1 signaling protects from development of vascular malformations while maintaining organ‐specific endothelial differentiation and angiocrine portmanteau of the names Wingless and Int‐1 signaling. Abstract Background and Aims In hereditary hemorrhagic telangiectasia (HHT), severe liver vascular malformations are associated with ...
Christian David Schmid +20 more
wiley +1 more source
A Critical Review on the Evolution of Chitosan‐Based Injectable Hydrogels in Bone Regeneration
Advanced Materials Interfaces, EarlyView.The graphical illustration depicts hydrogel formulation using chitosan and biocompatible cross‐linkers, major advantages, and incorporation of cells, osteoinductive factors, and therapeutic drugs. Following injection, pH‐responsive gelation enables controlled drug release, promotes cell recruitment and osteogenic differentiation, enhances extracellular
Shivani Santosh Sakhrani +2 more
wiley +1 more source
Hepatology, EarlyView., 2022 Mesenchymal stem cells subset, educated by TNF‐α, are involved to generate inflammatory microenvironment and promote hepatocarcinogenesis Abstract Background and Aims Increasing evidence suggests that mesenchymal stem cells (MSCs) home to injured local tissues and the tumor microenvironment in the liver.
Chen Zong +9 more
wiley +1 more source