USP15 targets ALK3/BMPR1A for deubiquitylation to enhance bone morphogenetic protein signalling [PDF]
, 2014 Protein kinase ALK3/BMPR1A mediates bone morphogenetic protein (BMP) signalling through phosphorylation and activation of SMADs 1/5/8. SMAD6, a transcriptional target of BMP, negatively regulates the BMP pathway by recruiting E3 ubiquitin ligases and ...
Al-Salihi, Mazin A. +11 more
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Structural and Metabolic Changes in Bone
Animals, 2022 As an essential component of the skeleton, bone tissue provides solid support for the body and protects vital organs. Bone tissue is a reservoir of calcium, phosphate, and other ions that can be released or stored in a controlled manner to provide ...
Agata Wawrzyniak, Krzysztof Balawender
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BMP2/BMPR1A is linked to tumour progression in dedifferentiated liposarcomas [PDF]
, 2016 Bone Morphogenic Protein 2 (BMP2) is a multipurpose cytokine, important in the development of bone and cartilage, and with a role in tumour initiation and progression.
Cassidy, A.P. +3 more
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Journal of Experimental Orthopaedics, 2014 Background Trauma, osteomyelitis, bone tumour resections and congenital deformities are the main causes of bone deficiency in which autologous graft is the preferred treatment, but usually the bone supplies are limited.
Juan Carlos Jacinto‐Tinajero +6 more
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Genetics of ovulation rate in farm animals [PDF]
Veterinary World, 2013 Rate of ovulation (i.e. fecundity) is largely influenced by both genetic and environmental factors. The ovarian growth factorsincluding members of bone morphogenetic proteins (BMPs) play a central role in determining ovulation quota and litter size ...
Rohit Kumar +3 more
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Differential involvement of Wnt signaling in Bmp regulation of cancellous versus periosteal bone growth [PDF]
, 2017 Bone morphogenetic proteins (Bmp) are well-known to induce bone formation following chondrogenesis, but the direct role of Bmp signaling in the osteoblast lineage is not completely understood.
Bellido, Teresita +5 more
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Functional analysis of alleged NOGGIN mutation G92E disproves its pathogenic relevance.
PLoS ONE, 2012 We identified an amino acid change (p.G92E) in the Bone Morphogenetic Protein antagonist NOGGIN in a 22-month-old boy who presented with a unilateral brachydactyly type B phenotype. Brachydactyly type B is a skeletal malformation that has been associated
Julia Zimmer +6 more
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The spatiotemporal expression pattern of the bone morphogenetic protein family in rat ovary cell types during the estrous cycle. [PDF]
, 2003 In the mammalian ovary, great interest in the expression and function of the bone morphogenetic protein (BMP) family has been recently generated from evidence of their critical role in determining folliculogenesis and female fertility.
Erickson, Gregory F, Shimasaki, Shunichi
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The Dual Role of Bone Morphogenetic Proteins in Cancer
Molecular Therapy: Oncolytics, 2018 Bone morphogenetic proteins (BMPs) are a diverse class of molecules with over 20 growth factor proteins that belong to the transforming growth factor-β (TGF-β) family and are highly associated with bone formation and disease development.
Duc-Hiep Bach +2 more
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Experimental Spinal Fusion With Recombinant Human Bone Morphogenetic Protein-2 Without Decortication of Osseous Elements [PDF]
, 1997 Study Design. L4-L5 intertransverse process fusions were produced with 58 μg, 230 μg, or 920 μg of recombinant human bone morphogenetic protein-2 in 20 dogs. Eleven had traditional decortication of posterior elements before insertion of the implant. Nine
Dawson, Edgar G. +6 more
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