Structural Insights into Rational Design of Single-Domain Antibody-Based Antitoxins against Botulinum Neurotoxins [PDF]
Cell Reports, 2020 Summary: Botulinum neurotoxin (BoNT) is one of the most acutely lethal toxins known to humans, and effective treatment for BoNT intoxication is urgently needed.
Kwok-ho Lam +8 more
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Development of an Innovative in Vitro Potency Assay for Anti-Botulinum Antitoxins [PDF]
Toxins, 2016 Botulinum neurotoxins are bacterial proteins that cause botulism, a life-threatening disease. Therapy relies mostly on post-intoxication antibody treatment. The only accepted method to measure the potency of, and to approve, antitoxin preparations is the
Osnat Rosen +4 more
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Vaccines, 2022 Botulism is a paralytic disease caused by botulinum neurotoxins (BoNTs). Equine antitoxin is currently the standard therapy for botulism in human. The preparation of equine antitoxin relies on the immunization of horses with botulinum toxoid, which ...
Alon Ben David +13 more
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Detection of Clostridium tetani Neurotoxins Inhibited In Vivo by Botulinum Antitoxin B: Potential for Misleading Mouse Test Results in Food Controls [PDF]
Toxins, 2018 The presence of botulinum neurotoxin-producing Clostridia (BPC) in food sources is a public health concern. In favorable environmental conditions, BPC can produce botulinum neurotoxins (BoNTs) outside or inside the vertebrate host, leading to ...
Luca Bano +7 more
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Development and evaluation of candidate subunit vaccine and novel antitoxin against botulinum neurotoxin serotype E [PDF]
Human Vaccines & Immunotherapeutics, 2020 Botulinum neurotoxins (BoNTs) are among the most toxic proteins. Vaccination is an effective strategy to prevent botulism. To generate a vaccine suitable for human use, a recombinant non-His-tagged isoform of the Hc domain of botulinum neurotoxin ...
Dan-Yang Shi +9 more
doaj +3 more sources
Familial Cluster of Foodborne Botulism Associated with Homemade Dairy Products: A Case Series [PDF]
International Medical Case Reports JournalKhadijeh Saravani,1 Amirhosein Kamrava,2 Javad Poursamimi3 1Department of Forensic Medicine and Toxicology, Zabol University of Medical Science, Zabol, Iran; 2Student Research Committee, Zabol University of Medical Sciences, Zabol, Iran; 3Department of ...
Saravani K, Kamrava A, Poursamimi J
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Equine botulinum antitoxin for the treatment of infant botulism. [PDF]
Clin Vaccine Immunol, 2011 ABSTRACTInfant botulism is the most common form of human botulism in Argentina and the United States. BabyBIG (botulism immune globulin intravenous [human]) is the antitoxin of choice for specific treatment of infant botulism in the United States. However, its high cost limits its use in many countries.
Vanella de Cuetos EE +6 more
europepmc +3 more sources
Safety and Improved Clinical Outcomes in Patients Treated With New Equine-Derived Heptavalent Botulinum Antitoxin. [PDF]
Clin Infect Dis, 2017 Botulism is a rare, life-threatening paralytic illness. Equine-derived heptavalent botulinum antitoxin (HBAT), the only currently available treatment for noninfant botulism in the United States, was licensed in 2013. No reports have systematically examined safety and clinical benefit of HBAT among botulism patients.From March 2010 through March 2013 ...
Yu PA +9 more
europepmc +4 more sources
Peanut butter confirmed as the source in a case of infant botulism, United Kingdom, 2024 [PDF]
EurosurveillanceA 6-month-old infant was hospitalised with suspected infant botulism after being given peanut butter to reduce their risk of developing peanut allergy.
Gauri Godbole
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A Single Tri-Epitopic Antibody Virtually Recapitulates the Potency of a Combination of Three Monoclonal Antibodies in Neutralization of Botulinum Neurotoxin Serotype A. [PDF]
, 2018 The standard of treatment for botulism, equine antitoxin, is a foreign protein with associated safety issues and a short serum half-life which excludes its use as a prophylactic antitoxin and makes it a less-than-optimal therapeutic.
Brown, Jennifer L +14 more
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