Structural Insights into Rational Design of Single-Domain Antibody-Based Antitoxins against Botulinum Neurotoxins [PDF]
Cell Reports, 2020 Summary: Botulinum neurotoxin (BoNT) is one of the most acutely lethal toxins known to humans, and effective treatment for BoNT intoxication is urgently needed.
Kwok-ho Lam +8 more
doaj +6 more sources
Immunologic and Protective Properties of Subunit- vs. Whole Toxoid-Derived Anti-Botulinum Equine Antitoxin [PDF]
Vaccines, 2022 Botulism is a paralytic disease caused by botulinum neurotoxins (BoNTs). Equine antitoxin is currently the standard therapy for botulism in human. The preparation of equine antitoxin relies on the immunization of horses with botulinum toxoid, which ...
Alon Ben David +13 more
doaj +4 more sources
Development of an Innovative in Vitro Potency Assay for Anti-Botulinum Antitoxins [PDF]
Toxins, 2016 Botulinum neurotoxins are bacterial proteins that cause botulism, a life-threatening disease. Therapy relies mostly on post-intoxication antibody treatment. The only accepted method to measure the potency of, and to approve, antitoxin preparations is the
Osnat Rosen +4 more
doaj +5 more sources
Equine botulinum antitoxin for the treatment of infant botulism. [PDF]
Clin Vaccine Immunol, 2011 ABSTRACTInfant botulism is the most common form of human botulism in Argentina and the United States. BabyBIG (botulism immune globulin intravenous [human]) is the antitoxin of choice for specific treatment of infant botulism in the United States. However, its high cost limits its use in many countries.
Vanella de Cuetos EE +6 more
europepmc +4 more sources
Safety and Improved Clinical Outcomes in Patients Treated With New Equine-Derived Heptavalent Botulinum Antitoxin. [PDF]
Clin Infect Dis, 2017 Botulism is a rare, life-threatening paralytic illness. Equine-derived heptavalent botulinum antitoxin (HBAT), the only currently available treatment for noninfant botulism in the United States, was licensed in 2013. No reports have systematically examined safety and clinical benefit of HBAT among botulism patients.From March 2010 through March 2013 ...
Yu PA +9 more
europepmc +5 more sources
Development and evaluation of candidate subunit vaccine and novel antitoxin against botulinum neurotoxin serotype E [PDF]
Human Vaccines & Immunotherapeutics, 2020 Botulinum neurotoxins (BoNTs) are among the most toxic proteins. Vaccination is an effective strategy to prevent botulism. To generate a vaccine suitable for human use, a recombinant non-His-tagged isoform of the Hc domain of botulinum neurotoxin ...
Dan-Yang Shi +9 more
doaj +4 more sources
Detection of Clostridium tetani Neurotoxins Inhibited In Vivo by Botulinum Antitoxin B: Potential for Misleading Mouse Test Results in Food Controls [PDF]
Toxins, 2018 The presence of botulinum neurotoxin-producing Clostridia (BPC) in food sources is a public health concern. In favorable environmental conditions, BPC can produce botulinum neurotoxins (BoNTs) outside or inside the vertebrate host, leading to ...
Luca Bano +7 more
doaj +4 more sources
Outbreak of Foodborne Botulism in Alexandria, Egypt: Modulating Indications for Administration of Heptavalent Botulinum Antitoxin [PDF]
Environmental Science and Pollution Research, 2021 Abstract Background: In October 2019, 94 patients were admitted into Alexandria Poison Center (APC) with a history of ingestion of Feseekh (salted fish). As a trial to allocate the resources, not all patients were given Heptavalent botulinum antitoxin (HBAT) immediately.The current study aimed to portray the clinical characteristics of the ...
Sara Attia Ghitani +4 more
openalex +5 more sources
New equine antitoxins to botulinum neurotoxins serotypes A and B [PDF]
Biologicals, 2012 Hyperimmune monovalent antitoxins to botulinum neurotoxin serotypes A and B have been produced by immunizing horses with newly developed formalin toxoids. After primary immunization, horses developed acceptable prophylactic antibody titers (1-5 IU/mL). Three horses received additional toxoid booster injections to induce hyperimmune antibody titers with
D. Li, Pravina Mattoo, James E. Keller
openalex +4 more sources
Antitoxin reduces botulinum side effects [PDF]
Eye, 1988 Les neurotoxines de C.b., tres toxiques, agissent par inhibition de liberation d'acetylcholine, neurotransmetteur. La nature specifique de cette inhibition est discutee etl la preparation de toxine de type A purifiee specifiquement pour usage clinique est ...
Alan B. Scott
openalex +3 more sources