Detection of Clostridium tetani Neurotoxins Inhibited In Vivo by Botulinum Antitoxin B: Potential for Misleading Mouse Test Results in Food Controls [PDF]
Toxins, 2018 The presence of botulinum neurotoxin-producing Clostridia (BPC) in food sources is a public health concern. In favorable environmental conditions, BPC can produce botulinum neurotoxins (BoNTs) outside or inside the vertebrate host, leading to ...
Luca Bano +2 more
exaly +6 more sources
Immunologic and Protective Properties of Subunit- vs. Whole Toxoid-Derived Anti-Botulinum Equine Antitoxin [PDF]
Vaccines, 2022 Botulism is a paralytic disease caused by botulinum neurotoxins (BoNTs). Equine antitoxin is currently the standard therapy for botulism in human. The preparation of equine antitoxin relies on the immunization of horses with botulinum toxoid, which ...
Ran Zichel +2 more
exaly +4 more sources
When BAT Precedes BIG‐IV in Infant Botulism: The Need for Structured Antitoxin Decision‐Pathway Reporting in Case Reports [PDF]
Clinical Case ReportsIn infant botulism, use of equine‐derived botulinum antitoxin before BIG‐IV may be clinically justified when the infant‐specific product is delayed.
Muhammad Abdullah Awan +1 more
doaj +3 more sources
Development and evaluation of candidate subunit vaccine and novel antitoxin against botulinum neurotoxin serotype E [PDF]
Human Vaccines and Immunotherapeutics, 2020 Botulinum neurotoxins (BoNTs) are among the most toxic proteins. Vaccination is an effective strategy to prevent botulism. To generate a vaccine suitable for human use, a recombinant non-His-tagged isoform of the Hc domain of botulinum neurotoxin ...
Yunzhou Yu +2 more
exaly +3 more sources
Development of an Innovative in Vitro Potency Assay for Anti-Botulinum Antitoxins [PDF]
Toxins, 2016 Botulinum neurotoxins are bacterial proteins that cause botulism, a life-threatening disease. Therapy relies mostly on post-intoxication antibody treatment. The only accepted method to measure the potency of, and to approve, antitoxin preparations is the
Osnat Rosen +4 more
doaj +5 more sources
Equine botulinum antitoxin for the treatment of infant botulism. [PDF]
Clin Vaccine Immunol, 2011 ABSTRACTInfant botulism is the most common form of human botulism in Argentina and the United States. BabyBIG (botulism immune globulin intravenous [human]) is the antitoxin of choice for specific treatment of infant botulism in the United States. However, its high cost limits its use in many countries.
Vanella de Cuetos EE +6 more
europepmc +5 more sources
Botulism in Spain: Epidemiology and Outcomes of Antitoxin Treatment, 1997–2019 [PDF]
Toxins, 2022 Background: Botulism is a low incidence but potentially fatal infectious disease caused by neurotoxins produced mainly by Clostridium botulinum.
Marina Peñuelas +8 more
doaj +5 more sources
Therapeutic efficacy of equine botulism antitoxin in Rhesus macaques. [PDF]
PLoS ONE, 2017 There are currently no licensed vaccines available for prevention of botulism in humans. The vaccination is not desirable due to expanding therapeutic indications of botulinum toxins.
Shantha Kodihalli +6 more
doaj +3 more sources
Wound Botulism Complicating a Snake Bite Wound Following Traditional Application of Raw Goat Skin Successfully Treated with Botulinum Antitoxin: A Case Report [PDF]
International Medical Case Reports JournalAhmad Shekaib Rasikh,1 Mohammad Maroof Aram,2 Abdul Tawab Noory,1 Aminulhaq Sarwary1 1Department of Infectious Diseases, Ali Abad Teaching Hospital, Kabul University of Medical Sciences, Kabul, Afghanistan; 2Department of Internal Medicine, Ali Abad ...
Rasikh AS, Aram MM, Noory AT, Sarwary A
doaj +2 more sources
Iatrogenic botulinum Toxin Type A poisoning with persistent unilateral vocal cord paralysis: a case report and clinical implications [PDF]
Frontiers in PharmacologyWith the continuous advancement of medical aesthetic technologies, botulinum toxin injection has emerged as a prevalent method for wrinkle removal and facial enhancement. However, improper administration can result in botulism incidents.
Shizhao Xiang, Yu Du, Yu Du
doaj +2 more sources