Results 11 to 20 of about 379 (143)

Botulism in Spain: Epidemiology and Outcomes of Antitoxin Treatment, 1997–2019 [PDF]

Toxins, 2022
Background: Botulism is a low incidence but potentially fatal infectious disease caused by neurotoxins produced mainly by Clostridium botulinum.
Marina Peñuelas, María Guerrero-Vadillo, Sylvia Valdezate, María Jesús Zamora, Inmaculada Leon-Gomez, Ángeles Flores-Cuéllar, Gema Carrasco, Oliva Díaz-García, Carmen Varela   +8 more
doaj   +3 more sources

Equine Botulinum Antitoxin for the Treatment of Infant Botulism

Clinical and Vaccine Immunology, 2011
ABSTRACTInfant botulism is the most common form of human botulism in Argentina and the United States. BabyBIG (botulism immune globulin intravenous [human]) is the antitoxin of choice for specific treatment of infant botulism in the United States. However, its high cost limits its use in many countries.
Elida E, Vanella de Cuetos, Rafael A, Fernandez, María I, Bianco, Omar J, Sartori, María L, Piovano, Carolina, Lúquez, Laura I T, de Jong   +6 more
openaire   +3 more sources

Neutralization of Tetanus Neurotoxin with Various Botulinum Antitoxins (A-F) in a Study to Isolate Clostridium botulinum from Field Samples [PDF]

Journal of Animal and Veterinary Advances, 2010
In a study to isolate Clostridium botulinum from field samples, 53 C. botulinum-like isolates were found neutralizable by botulinum antitoxins using the standard mouse bioassay. The neutralization results of 14 of them were found false-positive due to contamination with C.
Saeed, E. M. A., Bohnel, H., Gessler, Frank   +2 more
core   +4 more sources

A Case of Botulism Fast Adjusting with Antitoxin Administration in the Early Period and the Use of Electromyography in Diagnosis [PDF]

Journal of Pediatric Emergency and Intensive Care Medicine, 2021
Botulism is a rare but potentially life-threatening neuroparalytic syndrome caused by the action of a neurotoxin caused by the bacterium Clostridium botulinum. Early diagnosis and early treatment is important. In cases where botulism occurs sporadically,
Edin Botan, Serhan Özcan, Merve Havan, Emrah Gün, Merve Feyza Yüksel, Serdar Balsak, Özge Güzelmansur, Ömer Bektaş, Tanıl Kendirli   +8 more
doaj   +2 more sources

Detection of Clostridium tetani Neurotoxins Inhibited In Vivo by Botulinum Antitoxin B: Potential for Misleading Mouse Test Results in Food Controls

Toxins, 2018
The presence of botulinum neurotoxin-producing Clostridia (BPC) in food sources is a public health concern. In favorable environmental conditions, BPC can produce botulinum neurotoxins (BoNTs) outside or inside the vertebrate host, leading to ...
Luca Bano, Elena Tonon, Ilenia Drigo, Marco Pirazzini, Angela Guolo, Giovanni Farina, Fabrizio Agnoletti, Cesare Montecucco   +7 more
doaj   +2 more sources

Studying the differential efficacy of postsymptom antitoxin treatment in type A versus type B botulism using a rabbit spirometry model

Disease Models & Mechanisms, 2018
Botulinum neurotoxin (BoNT) serotypes A, B and E are responsible for most cases of human botulism. The only approved therapy for botulism is antitoxin treatment administered to patients after symptom onset.
Amram Torgeman, Arieh Schwartz, Eran Diamant, Tzadok Baruchi, Eyal Dor, Alon Ben David, Avi Pass, Ada Barnea, Arnon Tal, Amir Rosner, Osnat Rosen, Ran Zichel   +11 more
doaj   +2 more sources

Use of Botulism Antitoxin Heptavalent (A, B, C, D, E, F, G)—(Equine) (BAT^®) in Clinical Study Subjects and Patients: A 15-Year Systematic Safety Review

Toxins, 2021
Botulism is a rare, sometimes fatal paralytic illness caused by botulinum neurotoxins. BAT® (Botulism Antitoxin Heptavalent (A, B, C, D, E, F, G)—(Equine)) is an equine-derived heptavalent botulinum antitoxin indicated for the treatment of symptomatic ...
Geraldine S. Parrera, Hugo Astacio, Priya Tunga, Deborah M. Anderson, Christine L. Hall, Jason S. Richardson   +5 more
doaj   +2 more sources

Double Sandwich ELISA Modified Method for the Detection of Clostridium Botulinum Type E [PDF]

Journal of Fasa University of Medical Sciences, 2013
Background & Objective: A very small amount of botulinum toxin can cause death and on the other hand, there is no cure for its poison other than antitoxin.
Mohammad Ebrahim minaei, Mojtaba Saadati
doaj   +2 more sources

Production of monoclonal antibodies against botulinum neurotoxin in Nicotiana benthamiana

Human Vaccines & Immunotherapeutics
Botulism is a fatal neurologic disease caused by the botulinum toxin (BoNT) produced by Clostridium botulinum. It is a rare but highly toxic disease with symptoms, such as cramps, nausea, vomiting, diarrhea, dysphagia, respiratory failure, muscle ...
Kornchanok Sangprasat, Christine Joy I. Bulaon, Kaewta Rattanapisit, Theerakarn Srisangsung, Perawat Jirarojwattana, Apidsada Wongwatanasin, Waranyoo Phoolcharoen   +6 more
doaj   +2 more sources

Camelid VHHs Fused to Human Fc Fragments Provide Long Term Protection Against Botulinum Neurotoxin A in Mice

Toxins, 2019
The bacterium Clostridium botulinum is the causative agent of botulism—a severe intoxication caused by botulinum neurotoxin (BoNT) and characterized by damage to the nervous system. In an effort to develop novel C.
Svetlana A. Godakova, Anatoly N. Noskov, Irina D. Vinogradova, Galina A. Ugriumova, Andrey I. Solovyev, Ilias B. Esmagambetov, Amir I. Tukhvatulin, Denis Y. Logunov, Boris S. Naroditsky, Dmitry V. Shcheblyakov, Aleksandr L. Gintsburg   +10 more
doaj   +2 more sources