A cell-based alternative to the mouse potency assay for pharmaceutical type E botulinum antitoxins
ALTEX: Alternatives to Animal Experimentation, 2022 The pharmacopeia mouse neutralization assay (PMNA) is the standard method for determining the potency of pharmaceutical botulinum antitoxins. However, a PMNA requires a large number of mice, and, thus, an alternative in vitro method to replace it is ...
Eran Diamant +11 more
doaj +6 more sources
Equine botulinum antitoxin for the treatment of infant botulism. [PDF]
Clin Vaccine Immunol, 2011 ABSTRACTInfant botulism is the most common form of human botulism in Argentina and the United States. BabyBIG (botulism immune globulin intravenous [human]) is the antitoxin of choice for specific treatment of infant botulism in the United States. However, its high cost limits its use in many countries.
Vanella de Cuetos EE +6 more
europepmc +4 more sources
Clinical characteristics and predictors of prolonged hospitalization in patients with cosmetic botulinum toxin poisoning: a retrospective cohort study [PDF]
Frontiers in MedicineBackgroundThe increasing cosmetic use of botulinum toxin has been accompanied by poisoning events related to inappropriate administration, including excessive dosing, unapproved or unverifiable products, self-injection, and procedures performed outside ...
Yu-quan Chen +5 more
doaj +2 more sources
Neutralization of Tetanus Neurotoxin with Various Botulinum Antitoxins (A-F) in a Study to Isolate Clostridium botulinum from Field Samples [PDF]
Journal of Animal and Veterinary Advances, 2010 In a study to isolate Clostridium botulinum from field samples, 53 C. botulinum-like isolates were found neutralizable by botulinum antitoxins using the standard mouse bioassay. The neutralization results of 14 of them were found false-positive due to contamination with C.
Saeed, E. M. A. +2 more
core +5 more sources
Wound Botulism Complicating a Snake Bite Wound Following Traditional Application of Raw Goat Skin Successfully Treated with Botulinum Antitoxin: A Case Report [PDF]
International Medical Case Reports JournalAhmad Shekaib Rasikh,1 Mohammad Maroof Aram,2 Abdul Tawab Noory,1 Aminulhaq Sarwary1 1Department of Infectious Diseases, Ali Abad Teaching Hospital, Kabul University of Medical Sciences, Kabul, Afghanistan; 2Department of Internal Medicine, Ali Abad ...
Rasikh AS, Aram MM, Noory AT, Sarwary A
doaj +2 more sources
Cell Reports, 2020 Summary: Botulinum neurotoxin (BoNT) is one of the most acutely lethal toxins known to humans, and effective treatment for BoNT intoxication is urgently needed.
Kwok-ho Lam +8 more
doaj +3 more sources
Iatrogenic botulinum Toxin Type A poisoning with persistent unilateral vocal cord paralysis: a case report and clinical implications [PDF]
Frontiers in PharmacologyWith the continuous advancement of medical aesthetic technologies, botulinum toxin injection has emerged as a prevalent method for wrinkle removal and facial enhancement. However, improper administration can result in botulism incidents.
Shizhao Xiang, Yu Du, Yu Du
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Therapeutic efficacy of equine botulism antitoxin in Rhesus macaques. [PDF]
PLoS ONE, 2017 There are currently no licensed vaccines available for prevention of botulism in humans. The vaccination is not desirable due to expanding therapeutic indications of botulinum toxins.
Shantha Kodihalli +6 more
doaj +2 more sources
A Case of Botulism Fast Adjusting with Antitoxin Administration in the Early Period and the Use of Electromyography in Diagnosis [PDF]
Journal of Pediatric Emergency and Intensive Care Medicine, 2021 Botulism is a rare but potentially life-threatening neuroparalytic syndrome caused by the action of a neurotoxin caused by the bacterium Clostridium botulinum. Early diagnosis and early treatment is important. In cases where botulism occurs sporadically,
Edin Botan +8 more
doaj +2 more sources
Botulism in Spain: Epidemiology and Outcomes of Antitoxin Treatment, 1997–2019 [PDF]
Toxins, 2022 Background: Botulism is a low incidence but potentially fatal infectious disease caused by neurotoxins produced mainly by Clostridium botulinum.
Marina Peñuelas +8 more
doaj +3 more sources