Results 1 to 10 of about 379 (143)
Development of an Innovative in Vitro Potency Assay for Anti-Botulinum Antitoxins [PDF]
Toxins, 2016 Botulinum neurotoxins are bacterial proteins that cause botulism, a life-threatening disease. Therapy relies mostly on post-intoxication antibody treatment. The only accepted method to measure the potency of, and to approve, antitoxin preparations is the mouse lethality neutralization bioassay.
Osnat Rosen +4 more
doaj +5 more sources
Vaccines, 2022 Botulism is a paralytic disease caused by botulinum neurotoxins (BoNTs). Equine antitoxin is currently the standard therapy for botulism in human. The preparation of equine antitoxin relies on the immunization of horses with botulinum toxoid, which ...
Alon Ben David +13 more
doaj +2 more sources
Human Vaccines & Immunotherapeutics, 2020 Botulinum neurotoxins (BoNTs) are among the most toxic proteins. Vaccination is an effective strategy to prevent botulism. To generate a vaccine suitable for human use, a recombinant non-His-tagged isoform of the Hc domain of botulinum neurotoxin ...
Dan-Yang Shi +9 more
doaj +2 more sources
Therapeutic efficacy of equine botulism antitoxin in Rhesus macaques. [PDF]
PLoS ONE, 2017 There are currently no licensed vaccines available for prevention of botulism in humans. The vaccination is not desirable due to expanding therapeutic indications of botulinum toxins.
Shantha Kodihalli +6 more
doaj +2 more sources
Diagnosis and treatment of botulism after botulinum toxin type A injections: report of 9 cases
Di-san junyi daxue xuebao, 2021 Objective To explore the diagnostic criteria of botulism after botulinum toxin type A (BT/A) injection and observe the therapeutic effect of botulinum antitoxin.
HE Ping +5 more
doaj +1 more source
Clostridium botulinum – like organism bacteremia in a user of black tar heroin
IDCases, 2021 Wound botulism due to introduction of the anaerobic bacteria, Clostridium botulinum, into otherwise sterile, relatively anaerobic tissue is a known complication of black tar heroin use.
Therese Battiola +4 more
doaj +1 more source
A Rabbit Model for the Evaluation of Drugs for Treating the Chronic Phase of Botulism
Toxins, 2021 Antitoxin, the only licensed drug therapy for botulism, neutralizes circulating botulinum neurotoxin (BoNT). However, antitoxin is no longer effective when a critical amount of BoNT has already entered its target nerve cells.
Amram Torgeman +6 more
doaj +1 more source
Cell Reports, 2020 Summary: Botulinum neurotoxin (BoNT) is one of the most acutely lethal toxins known to humans, and effective treatment for BoNT intoxication is urgently needed.
Kwok-ho Lam +8 more
doaj +1 more source
A Three-Monoclonal Antibody Combination Potently Neutralizes BoNT/G Toxin in Mice
Toxins, 2023 Equine-derived antitoxin (BAT®) is the only treatment for botulism from botulinum neurotoxin serotype G (BoNT/G). BAT® is a foreign protein with potentially severe adverse effects and is not renewable.
Yongfeng Fan +9 more
doaj +1 more source
Wound Botulism Caused by Botulinum Neurotoxin Type A in a Chronic Parenteral Drug Abuser
Case Reports in Neurology, 2020 Botulism is an acute paralytic disease caused by botulinum neurotoxin (BoNT)-mediated inhibition of neurosignaling at the neuromuscular junction. BoNTs are produced by gram positive, anaerobic, spore-forming bacteria from the genus Clostridium,most ...
Sohun Awsare +2 more
doaj +1 more source