Results 1 to 10 of about 33,694 (186)

New Equine Antitoxins to Botulinum Neurotoxins Serotypes a and B [PDF]

Biologicals, 2012
Hyperimmune monovalent antitoxins to botulinum neurotoxin serotypes A and B have been produced by immunizing horses with newly developed formalin toxoids. After primary immunization, horses developed acceptable prophylactic antibody titers (1-5 IU/mL). Three horses received additional toxoid booster injections to induce hyperimmune antibody titers with
D, Li, P, Mattoo, J E, Keller
exaly   +3 more sources

Anomalous Enhancement of Botulinum Toxin Type A Neurotoxicity in the Presence of Antitoxin

Toxicon, 2001
The neutralization of botulinum toxin serotype A with polyclonal equine antitoxin was studied in isolated mouse hemidiaphragms and compared to the same action in live mice. The biological activity of the toxin in the isolated muscle could be markedly reduced with excess antitoxin, estimated as 3:1 molar ratios of IgG Ab:toxin or better.
J D Marks, S S Deshpande
exaly   +3 more sources

A Novel Botulinum Neurotoxin, Previously Reported as Serotype H, Has a Hybrid-Like Structure With Regions of Similarity to the Structures of Serotypes a and F and Is Neutralized With Serotype A Antitoxin.

Journal of Infectious Diseases, 2016
Brian H Raphael, Sabine Pellett, Janet K Dykes   +2 more
exaly  

Anti‐Immunoglobulin Responses to IgG, F(Ab′)2, and Fab Botulinum Antitoxins in Mice

Immunopharmacology and Immunotoxicology, 2003
exaly  

Design and Production of Full-Length, Biologically Inactive Botulinum Neurotoxin Serotypes to Serve as Natively Folded Antigens for Antitoxin Generation

Toxicon
Marie-Anne Nahori, Carmen Klepka, Adina Przykopanski   +2 more
exaly  

Development of an Innovative in Vitro Potency Assay for Anti-Botulinum Antitoxins [PDF]

Toxins, 2016
Botulinum neurotoxins are bacterial proteins that cause botulism, a life-threatening disease. Therapy relies mostly on post-intoxication antibody treatment. The only accepted method to measure the potency of, and to approve, antitoxin preparations is the
Osnat Rosen, Eyal Ozeri, Ada Barnea, Alon Ben David, Ran Zichel   +4 more
doaj   +6 more sources

Detection of Clostridium tetani Neurotoxins Inhibited In Vivo by Botulinum Antitoxin B: Potential for Misleading Mouse Test Results in Food Controls [PDF]

Toxins, 2018
The presence of botulinum neurotoxin-producing Clostridia (BPC) in food sources is a public health concern. In favorable environmental conditions, BPC can produce botulinum neurotoxins (BoNTs) outside or inside the vertebrate host, leading to ...
Luca Bano, Elena Tonon, Ilenia Drigo, Marco Pirazzini, Angela Guolo, Giovanni Farina, Fabrizio Agnoletti, Cesare Montecucco   +7 more
doaj   +5 more sources

Immunologic and Protective Properties of Subunit- vs. Whole Toxoid-Derived Anti-Botulinum Equine Antitoxin

Vaccines, 2022
Botulism is a paralytic disease caused by botulinum neurotoxins (BoNTs). Equine antitoxin is currently the standard therapy for botulism in human. The preparation of equine antitoxin relies on the immunization of horses with botulinum toxoid, which ...
Alon Ben David, Ada Barnea, Amram Torgeman, Eran Diamant, Eyal Dor, Arieh Schwartz, Osnat Rosen, Noa Caspi, Miki Saraf, Elad Lerer, Yaakov Adar, Edith Lupo, Einat Toister, Ran Zichel   +13 more
doaj   +4 more sources

When BAT Precedes BIG‐IV in Infant Botulism: The Need for Structured Antitoxin Decision‐Pathway Reporting in Case Reports [PDF]

Clinical Case Reports
In infant botulism, use of equine‐derived botulinum antitoxin before BIG‐IV may be clinically justified when the infant‐specific product is delayed.
Muhammad Abdullah Awan, Hammad‐ud‐din Raza   +1 more
doaj   +3 more sources

Development and evaluation of candidate subunit vaccine and novel antitoxin against botulinum neurotoxin serotype E

Human Vaccines & Immunotherapeutics, 2020
Botulinum neurotoxins (BoNTs) are among the most toxic proteins. Vaccination is an effective strategy to prevent botulism. To generate a vaccine suitable for human use, a recombinant non-His-tagged isoform of the Hc domain of botulinum neurotoxin ...
Dan-Yang Shi, Fu-Jia Liu, Yun-Yun Mao, Rong-Tian Cui, Jian-Sheng Lu, Yun-Zhou Yu, Xiao-Jie Dong, Zhi-Xin Yang, Zhi-Wei Sun, Xiao-Bin Pang   +9 more
doaj   +3 more sources