Results 31 to 40 of about 33,694 (186)

A Rabbit Model for the Evaluation of Drugs for Treating the Chronic Phase of Botulism

Toxins, 2021
Antitoxin, the only licensed drug therapy for botulism, neutralizes circulating botulinum neurotoxin (BoNT). However, antitoxin is no longer effective when a critical amount of BoNT has already entered its target nerve cells.
Amram Torgeman, Eran Diamant, Eyal Dor, Arieh Schwartz, Tzadok Baruchi, Alon Ben David, Ran Zichel   +6 more
doaj   +1 more source

The coevolution of toxin and antitoxin genes drives the dynamics of bacterial addiction complexes and intragenomic conflict [PDF]

, 2012
Bacterial genomes commonly contain 'addiction' gene complexes that code for both a toxin and a corresponding antitoxin. As long as both genes are expressed, cells carrying the complex can remain healthy.
Rankin, Daniel J., Leighton A. Turner, Daniel J. Rankin, Heinemann, Jack A., Brown, Sam P., Sam P. Brown, Turner, Leighton A., Jack A. Heinemann, Turner LA, Brown SP, Heinemann JA, Rankin DJ   +11 more
core   +1 more source

A Three-Monoclonal Antibody Combination Potently Neutralizes BoNT/G Toxin in Mice

Toxins, 2023
Equine-derived antitoxin (BAT®) is the only treatment for botulism from botulinum neurotoxin serotype G (BoNT/G). BAT® is a foreign protein with potentially severe adverse effects and is not renewable.
Yongfeng Fan, Jianlong Lou, Christina C. Tam, Weihua Wen, Fraser Conrad, Priscila Leal da Silva Alves, Luisa W. Cheng, Consuelo Garcia-Rodriguez, Shauna Farr-Jones, James D. Marks   +9 more
doaj   +1 more source

Feasibility and Safety of Washed Microbiota Transplantation as Salvage Therapy for Refractory Non-CDI Gut Pathogens in Critically Ill Patients. [PDF]

Microb Biotechnol
Ten patients with definite gut infection evidence beyond CDI underwent 29 WMT infusions. 50% (5/10) of patients obtained clinical cure after WMT. 20% (2/10) of patients achieved clinical improvement and 30% (3/10) showed no response 7 days after WMT. One transient WMT‐related fever occurred (1/29, 3.45%).
Xu J, Diao A, Ai R, Wu X, Wen Q, Xiao Y, He X, Yu Y, Zhang Z, Wang Y, Zhang Z, Zhang F, Cui B.   +12 more
europepmc   +2 more sources

Evaluation and isolation of Clostridium botulinum type E from fresh and smoked Cyprinus carpio, Rutilus frisii kutum and Hypophtalmicthys molitrix [PDF]

‬‭Majallah-i ̒Ilmī-i Shīlāt-i Īrān, 1999
In this study experiments were conducted to evaluate Clostridium botulinum type E in fresh and smoked Cyprinus carpio (60 samples) Rutilus frisii kutum (60 samples) and Hypophthalmichthys molitrix (60 samples). One hundred and eighty samples of fish were
R. Safari; I. Khandaghi
doaj   +1 more source

Wound Botulism Caused by Botulinum Neurotoxin Type A in a Chronic Parenteral Drug Abuser

Case Reports in Neurology, 2020
Botulism is an acute paralytic disease caused by botulinum neurotoxin (BoNT)-mediated inhibition of neurosignaling at the neuromuscular junction. BoNTs are produced by gram positive, anaerobic, spore-forming bacteria from the genus Clostridium,most ...
Sohun Awsare, David Chirikian, Forshing Lui   +2 more
doaj   +1 more source

Outbreak of foodborne botulism in Alexandria, Egypt: modulating indications for administration of heptavalent botulinum antitoxin [PDF]

Environmental Science and Pollution Research, 2021
Abstract Background: In October 2019, 94 patients were admitted into Alexandria Poison Center (APC) with a history of ingestion of Feseekh (salted fish). As a trial to allocate the resources, not all patients were given Heptavalent botulinum antitoxin (HBAT) immediately.The current study aimed to portray the clinical characteristics of the ...
Sara Attia Ghitani, Maha Ghanem, Eman A. Sultan, Maram Atef, Maii F. Henaidy   +4 more
openaire   +3 more sources

Botulism outbreak in a rural Ethiopia: a case series

BMC Infectious Diseases, 2021
Background Foodborne botulism, a toxin-mediated illness caused by Clostridium botulinum, is a public health emergency. Types A, B, and E C. botulinum toxins commonly cause human disease.
Tigist Bacha, Ermias Abebaw, Ayalew Moges, Amsalu Bekele, Afework Tamiru, Ishmael Shemsedin, Dawd S. Siraj, Daddi Jima, Wondwossen Amogne   +8 more
doaj   +1 more source

EGYPTIAN PROTOCOL FOR MANAGEMENT OF BOTULISM

Egyptian Society of Clinical Toxicology Journal, 2019
Botulism is a muscle-paralyzing disease caused by a toxin made by a bacterium called Clostridium botulinum. Botulinum toxin binds irreversibly to presynaptic nerve endings at neuromuscular junctions.
Samah Elnagdy
doaj   +1 more source

Clinical cases of atypical and severe botulism

Zaporožskij Medicinskij Žurnal, 2020
The aim of the work was to present two clinical cases of botulism: the atypical course and the severe course with late administration of heptavalent botulinum antitoxin, which still had a significant positive clinical effect and contributed to a faster ...
O. L. Ivakhiv, N. Yu. Vyshnevska
doaj   +1 more source