Results 11 to 20 of about 1,891 (175)
Pediatric Botulism and Use of Equine Botulinum Antitoxin in Children: A Systematic Review [PDF]
Clinical Infectious Diseases, 2017 Botulism manifests with cranial nerve palsies and flaccid paralysis in children and adults. Botulism must be rapidly identified and treated; however, clinical presentation and treatment outcomes of noninfant botulism in children are not well described.We searched 12 databases for peer-reviewed and non-peer-reviewed reports with primary data on botulism
Stephanie E. Griese +6 more
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Clostridium BotulinumTypes A and B Toxin-Antitoxin Reactions [PDF]
Journal of Hygiene, 1955 SummaryC. botulinumtypes A and B toxins required larger amounts of antitoxin for neutralization when fractions of the test dose of toxin were used than would be expected.The degree of this dilution effect, i.e. the dilution ratio, varied with different sera.
A. J. Fulthorpe
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Familial Cluster of Foodborne Botulism Associated with Homemade Dairy Products: A Case Series [PDF]
International Medical Case Reports JournalKhadijeh Saravani,1 Amirhosein Kamrava,2 Javad Poursamimi3 1Department of Forensic Medicine and Toxicology, Zabol University of Medical Science, Zabol, Iran; 2Student Research Committee, Zabol University of Medical Sciences, Zabol, Iran; 3Department of ...
Saravani K, Kamrava A, Poursamimi J
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Japanese Journal of Infectious Diseases, 2023 Equine botulinum antitoxin is one of the most popular countermeasures for human botulism. The unitage of the antitoxin product is defined according to national minimum requirement or pharmacopoeia in each country by referring to national standard antitoxins for four types (A, B, E, and F). With the expected depletion of the national standard antitoxins,
Masahiro Yutani +4 more
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TITRATION OF BOTULINUM ANTITOXIN OF LOW LEVELS BY THE SCORE METHOD
Japanese Journal of Medical Science and Biology, 1990 Botulinum antitoxin is commonly titrated by injecting a mixture of toxin and antitoxin into mice and by utilizing deaths as a marker to measure the amount of unneutralized toxin. We attempted to titrate antitoxin by converting the severity of symptoms (notably palsy) and time-to-death in days into scores.
Motohide Takahashi +3 more
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Neutralization of Tetanus Neurotoxin with Various Botulinum Antitoxins (A-F) in a Study to Isolate Clostridium botulinum from Field Samples [PDF]
Journal of Animal and Veterinary Advances, 2010 In a study to isolate Clostridium botulinum from field samples, 53 C. botulinum-like isolates were found neutralizable by botulinum antitoxins using the standard mouse bioassay. The neutralization results of 14 of them were found false-positive due to contamination with C.
Elhassan M. A. Saeed +2 more
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Algal chloroplast produced camelid
Plant Biotechnology Journal, 2014 SummaryWe have produced three antitoxins consisting of the variable domains of camelid heavy chain‐only antibodies (VHH) by expressing the genes in the chloroplast of green algae. These antitoxins accumulate as soluble proteins capable of binding and neutralizing botulinum neurotoxin.
Daniel J. Barrera +9 more
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A cell-based alternative to the mouse potency assay for pharmaceutical type E botulinum antitoxins
ALTEX, 2021 The pharmacopeia mouse neutralization assay (PMNA) is the standard method for determining the potency of pharmaceutical botulinum antitoxins. However, a PMNA requires a large number of mice, and, thus, an alternative in vitro method to replace it is needed.
Eran Diamant
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Peanut butter confirmed as the source in a case of infant botulism, United Kingdom, 2024 [PDF]
EurosurveillanceA 6-month-old infant was hospitalised with suspected infant botulism after being given peanut butter to reduce their risk of developing peanut allergy.
Gauri Godbole
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Efficient Serum Clearance of Botulinum Neurotoxin Achieved Using a Pool of Small Antitoxin Binding Agents [PDF]
Infection and Immunity, 2009 ABSTRACTAntitoxins for botulinum neurotoxins (BoNTs) and other toxins are needed that can be produced economically with improved safety and shelf-life properties compared to conventional therapeutics with large-animal antisera. Here we show that protection from BoNT lethality and rapid BoNT clearance through the liver can be elicited in mice by ...
Jorge Sepúlveda +4 more
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