Results 81 to 90 of about 2,075 (191)

A novel strategy for development of recombinant antitoxin therapeutics tested in a mouse botulism model. [PDF]

, 2012
Antitoxins are needed that can be produced economically with improved safety and shelf life compared to conventional antisera-based therapeutics. Here we report a practical strategy for development of simple antitoxin therapeutics with substantial ...
Robert P Webb, Leonard A. Smith (82190), Charles B. Shoemaker (189753), Charles B Shoemaker, Xiaochuan Feng (82466), Karen Baldwin (189729), Jacqueline M. Tremblay (189705), Kwasi Ofori, Saul Tzipori, Robert P. Webb (189744), Kwasi Ofori (189720), Patrick M Wright, Tzipori Saul, Xiaochuan Feng, Patrick M. Wright (189749), Wright Patrick M., Leysath Clinton E., Leonard A Smith, Jean Mukherjee (189699), Jean Mukherjee, Clinton E Leysath, Smith Leonard A., Jacqueline M Tremblay, Tremblay Jacqueline M., Clinton E. Leysath (189712), Baldwin Karen, Saul Tzipori (37482), Ofori Kwasi, Mukherjee Jean, Daniela Bedenice, Shoemaker Charles B., Webb Robert P., Karen Baldwin, Daniela Bedenice (189740), Feng Xiaochuan, Bedenice Daniela   +35 more
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Investigating Avian Neglect and Welfare Violations: Case Studies in South Korea

Case Reports in Veterinary Medicine, Volume 2025, Issue 1, 2025.
This paper investigates three significant cases of avian welfare violations in South Korea, emphasizing the detrimental effects of neglect and inadequate management practices. The first case concerns the mass mortality of birds in a Seoul park due to methomyl poisoning. The second case focuses on a botulism outbreak occurring on a quail farm. The third
Goun Park, JaeKyeom Kim, Chunghyun Kim, Isabel Pires   +3 more
wiley   +1 more source

Report of the Scientific Committee of the Spanish Agency for Food Safety and Nutrition (AESAN) on the risk assessment of botulism resulting from the consumption of vacuum‐packed or modified atmosphere‐packed foods

Food Risk Assess Europe, Volume 3, Issue 1, January 2025.
Abstract Foodborne botulism is caused by the ingestion of a neurotoxin (BoNT) primarily produced by Clostridium botulinum. This bacterium is classified into six phenotypic Groups, with Groups I and II being associated with human disease. BoNT are divided into seven main types with different antigenic potentials, of which types A, B, E, and F are ...
María Dolores Rodrigo Aliaga, Rosa María Capita González, Baltasar Mayo Pérez, Gloria Sánchez Moragas, Antonio Valero Díaz   +4 more
wiley   +1 more source

Clostridium difficile and its toxins [PDF]

, 1974
An investigation of Clostridium difficile has shown : 1. that the organism is resistant to cresols and phenolq and may be grown from material grossly contaminated with other organisms by culture in media containing these substances; strains ...
Hafiz, Saleem
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Cost savings associated with timely treatment of botulism with botulism antitoxin heptavalent product. [PDF]

, 2019
BACKGROUND:Botulism is a rare, serious, and sometimes fatal paralytic illness caused by exposure to neurotoxins produced by Clostridium botulinum bacteria.
S Pinar Bilir, Jason S Richardson, Diana L Arper, Veena R Kumar, Eliza Kruger, Deborah M Anderson   +5 more
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What is the role of microbial biotechnology and genetic engineering in medicine?

MicrobiologyOpen, Volume 13, Issue 2, April 2024.
Microbial biotechnology, the technological application of microorganisms, has been instrumental in producing significant natural bioactive products. These include antibiotics, antifungals, anticancer drugs, antiparasitics, antivirals, immunosuppressants, toxoid vaccines, and therapeutic enzymes.
Fernando Santos‐Beneit
wiley   +1 more source

Emerg Infect Dis [PDF]

Five cases of intestinal toxemia botulism in adults were identified within an 18-month period in or near Toronto, Ontario, Canada. We describe findings for 3 of the 5 case-patients.

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Phrenic nerve-hemidiaphragm as a highly sensitive replacement assay for determination of functional botulinum toxin antibodies [PDF]

, 2011
International audienceBotulinum neurotoxins induce a prolonged muscle paralysis by specifically blocking the release of neuronal transmitters from peripheral nerve junctions. Potency testing of toxin and antitoxin therapies is entirely dependent on mouse
R.G.A. Jones, Rasetti-Escargueil, Christine, D. Sesardic, Sesardic, D., C. Rasetti-Escargueil, P. Rigsby, Rigsby, P., Y. Liu, Liu, Y., Jones, R.G.A.   +9 more
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Peripheral nervous system and neuromuscular disorders in the emergency department: A review

Academic Emergency Medicine, Volume 31, Issue 4, Page 386-397, April 2024.
Abstract Introduction Acute presentations and emergencies in neuromuscular disorders (NMDs) often challenge clinical acumen. The objective of this review is to refine the reader's approach to history taking, clinical localization and early diagnosis, as well as emergency management of neuromuscular emergencies.
Ajith Sivadasan, Miguel A. Cortel‐LeBlanc, Achelle Cortel‐LeBlanc, Hans Katzberg   +3 more
wiley   +1 more source

Efficacy of equine botulism antitoxin in botulism poisoning in a guinea pig model [PDF]

, 2019
BackgroundBotulism is a disease caused by neurogenic toxins that block acetylcholine release, resulting in potentially life threatening neuroparalysis. Seven distinct serotypes of botulinum neurotoxins (BoNTs) have been described and are found in nature ...
Teresa Takla, Nancy Neimuth, Shantha Kodihalli (630152), Shantha Kodihalli, Andrew Emanuel (4610887), Karen Gillum, Hongyu Qiu, Nancy Neimuth (6199493), Hongyu Qiu (317690), Douglas Barker (6199487), Andrew Emanuel, Karen Gillum (6199490), Douglas Barker, Teresa Takla (4610884)   +13 more
core   +1 more source