Results 81 to 90 of about 379 (143)

Role of Homologous Fc Fragment in the Potency and Efficacy of Anti‐Botulinum Antibody Preparations

, 2017
The only approved treatment for botulism relies on passive immunity which is mostly based on antibody preparations collected from hyper‐immune horses. The IgG Fc fragment is commonly removed from these heterologous preparations to reduce the incidence of
Arik Makovitzki, Eyal Ozeri, Eran Diamant, Avishai Mimran, Amram Torgeman, Alon Ben David, Arieh Schwartz, Ran Zichel, Osnat Rosen, Ada Barnea   +9 more
core   +1 more source

Algal chloroplast produced camelid VHH antitoxins are capable of neutralizing botulinum neurotoxin [PDF]

, 2015
We have produced three antitoxins consisting of the variable domains of camelid heavy chain-only antibodies (VH H) by expressing the genes in the chloroplast of green algae.
Shoemaker, Charles B, Rosenberg, Julian N, Ngoi, Soo‐Mun, Barrera, Daniel J, Oyler, George A, Mayfield, Stephen P, Chiu, Joanna G, Debatis, Michelle, Chang, John T, Chang, Yung‐Nien   +9 more
core   +1 more source

A novel strategy for development of recombinant antitoxin therapeutics tested in a mouse botulism model.

, 2012
Antitoxins are needed that can be produced economically with improved safety and shelf life compared to conventional antisera-based therapeutics. Here we report a practical strategy for development of simple antitoxin therapeutics with substantial ...
Robert P Webb, Leonard A. Smith (82190), Charles B. Shoemaker (189753), Charles B Shoemaker, Xiaochuan Feng (82466), Karen Baldwin (189729), Jacqueline M. Tremblay (189705), Kwasi Ofori, Saul Tzipori, Robert P. Webb (189744), Kwasi Ofori (189720), Patrick M Wright, Tzipori Saul, Xiaochuan Feng, Patrick M. Wright (189749), Wright Patrick M., Leysath Clinton E., Leonard A Smith, Jean Mukherjee (189699), Jean Mukherjee, Clinton E Leysath, Smith Leonard A., Jacqueline M Tremblay, Tremblay Jacqueline M., Clinton E. Leysath (189712), Baldwin Karen, Saul Tzipori (37482), Ofori Kwasi, Mukherjee Jean, Daniela Bedenice, Shoemaker Charles B., Webb Robert P., Karen Baldwin, Daniela Bedenice (189740), Feng Xiaochuan, Bedenice Daniela   +35 more
core   +1 more source

Foodborne botulism due to ingestion of home-canned green beans: two case reports

Journal of Medical Case Reports, 2018
Background Foodborne botulism is a life-threatening, rapidly progressive disease. It has an incidence of less than 10 cases per year in Germany and mostly affects several previously healthy people at the same time.
Dorothea Hellmich, Katja E. Wartenberg, Stephan Zierz, Tobias J. Mueller   +3 more
doaj   +1 more source

A rare symptom of foodborne botulism: dysgeusia. Case report and clinical review

Emergency Care Journal
Clostridium botulinum has become one of the most well-known microorganisms in medical history, thanks to both fatal botulism epidemics and the recent medical use of botulinum neurotoxin.
Simone Esposito, Francesco Coletta, Giovanna Di Maiolo, Filomena Lo Chiatto, Pasquale Rinaldi, Anna Lanza, Getano Panico, Crescenzo Sala, Antonio Tomasello, Romolo Villani   +9 more
doaj   +1 more source

The toxic antigenic factors produced by Clostridium botulinum types C and D [PDF]

, 1971
The journals have been scanned in colour with a HP 5590 scanner; 600 dpi. Adobe Acrobat v.11 was used to OCR the text and also for the merging and conversion to the final presentation PDF-format.The toxic factors produced by Clostridium botulinum (Van ...
Jansen, B.C.
core  

Cost savings associated with timely treatment of botulism with botulism antitoxin heptavalent product.

, 2019
BACKGROUND:Botulism is a rare, serious, and sometimes fatal paralytic illness caused by exposure to neurotoxins produced by Clostridium botulinum bacteria.
S Pinar Bilir, Jason S Richardson, Diana L Arper, Veena R Kumar, Eliza Kruger, Deborah M Anderson   +5 more
core   +1 more source

Four Cases of Food-Borne Botulism in a Family

پزشکی بالینی ابن سینا, 2002
Botulism is caused  by a neurotoxin produced from the anaerobic,    Spore-forming bacterium clostridium botulinum. Botulism have four     clinical  forms:1)Food –borne botulism   2)Wound botulism    3)Infant botulism    4)undetermined botulism, that the 
Fariba Keramat
doaj  

Emerg Infect Dis

Five cases of intestinal toxemia botulism in adults were identified within an 18-month period in or near Toronto, Ontario, Canada. We describe findings for 3 of the 5 case-patients.

core  

Phrenic nerve-hemidiaphragm as a highly sensitive replacement assay for determination of functional botulinum toxin antibodies

, 2011
International audienceBotulinum neurotoxins induce a prolonged muscle paralysis by specifically blocking the release of neuronal transmitters from peripheral nerve junctions. Potency testing of toxin and antitoxin therapies is entirely dependent on mouse
R.G.A. Jones, Rasetti-Escargueil, Christine, D. Sesardic, Sesardic, D., C. Rasetti-Escargueil, P. Rigsby, Rigsby, P., Y. Liu, Liu, Y., Jones, R.G.A.   +9 more
core   +1 more source