Results 11 to 20 of about 3,264 (192)

BP180 Is Critical in the Autoimmunity of Bullous Pemphigoid [PDF]

Frontiers in Immunology, 2017
Bullous pemphigoid (BP) is by far the most common autoimmune blistering dermatosis that mainly occurs in the elderly. The BP180 is a transmembrane glycoprotein, which is highly immunodominant in BP. The structure and location of BP180 indicate that it is
Yale Liu, Liang Li, Yumin Xia
doaj   +4 more sources

BP180/Collagen XVII:a molecular view [PDF]

International Journal of Molecular Sciences, 2021
BP180 is a type II collagenous transmembrane protein and is best known as the major autoantigen in the blistering skin disease bullous pemphigoid (BP).
Jussi Tuusa, Nina Kokkonen, Kaisa Tasanen, Tuusa, J. (Jussi), Tasanen, K. (Kaisa), Tasanen, Kaisa, Kokkonen, N. (Nina), Tuusa, Jussi, Kokkonen, Nina   +8 more
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Anti-BP180 Autoantibodies Are Present in Stroke and Recognize Human Cutaneous BP180 and BP180-NC16A [PDF]

Frontiers in Immunology, 2018
BackgroundCurrent evidence has revealed a significant association between bullous pemphigoid (BP) and neurological diseases (ND), including stroke, but the incidence of BP autoantibodies in patients with stroke has not previously been investigated ...
Yanan Wang, Hongzhong Jin, Aimee S. Payne, Xuming Mao, Christoph M. Hammers, Di Wang, Yiman Wang, Bin Peng, Li Li   +8 more
core   +4 more sources

Anti-BP180 Autoantibodies Are Present in Stroke and Recognize Human Cutaneous BP180 and BP180-NC16A [PDF]

Frontiers in Immunology, 2019
Objective: Current evidence has revealed a significant association between bullous pemphigoid (BP) and neurological diseases (ND), including stroke, but the incidence of BP autoantibodies in patients with stroke has not previously been investigated.
Yanan Wang, Xuming Mao, Di Wang, Christoph M. Hammers, Aimee S. Payne, Yiman Wang, Hongzhong Jin, Bin Peng, Li Li   +8 more
doaj   +2 more sources

BP180 dysfunction triggers spontaneous skin inflammation in mice [PDF]

Proceedings of the National Academy of Sciences, 2018
Significance BP180 is a cell–cell matrix adhesion molecule and is critical for attachment of epidermis to underlying dermis. We generated a dysfunctional BP180 mouse strain (Δ NC16A mice).
Zhi Liu, Yang Zhang, Zhen Liu, Bin-Jin Hwang, Ning Li, Luis A. Diaz, Maureen A. Su, Shengxiang Xiao, Susan W. Burette, Kendall Lough, Scott E. Williams, Jinbo Chen   +11 more
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Bullous pemphigoid and mucous membrane pemphigoid humoral responses differ in reactivity towards BP180 midportion and BP230 [PDF]

Frontiers in Immunology
BackgroundBullous pemphigoid (BP) and mucous membrane pemphigoid (MMP) are rare autoimmune blistering disorders characterized by autoantibodies (autoAbs) targeting dermo-epidermal junction components such as BP180 and BP230.
Feliciana Mariotti, Anna Pira, Naomi De Luca, Anna Rita Giampetruzzi, Filomena Russo, Amilcare Cerri, Giulia Gasparini, Giulia Gasparini, Emanuele Cozzani, Emanuele Cozzani, Angelo V. Marzano, Angelo V. Marzano, Emiliano Antiga, Marzia Caproni, Pietro Quaglino, Marco Carrozzo, Biagio Didona, Giovanni Di Zenzo   +17 more
doaj   +8 more sources

Analysis of the autoimmune response against BP180 and BP230 in ethnic Poles with neurodegenerative disorders and bullous pemphigoid [PDF]

Central European Journal of Immunology, 2017
Recent studies postulated the association between bullous pemphigoid (BP) and neurodegenerative disorders (ND). The autoantibodies to BP180 and/or BP230 may be present not only in BP, but also in ND as neuronal isoforms of these proteins are identified ...
Justyna Gornowicz-Porowska, Agnieszka Seraszek-Jaros, Monika Bowszyc-Dmochowska, Elżbieta Kaczmarek, Paweł Pietkiewicz, Paweł Bartkiewicz, Marian Dmochowski   +6 more
doaj   +2 more sources

IgE autoantibodies against the intracellular domain of BP180

British Journal of Dermatology, 2009
BACKGROUND: Bullous pemphigoid (BP) is an autoimmune subepidermal blistering disease characterized by autoantibodies against the hemidesmosomal proteins BP180 (type XVII collagen) and BP230.
Gibbs, Bernhard F, Dresow, S.K., D. Zillikens, B.F. Gibbs, Sitaru, C., Oostingh, G.J., S.K. Dresow, Zillikens, Detlef, G.J. Oostingh, C. Sitaru, Recke, A., A. Recke   +11 more
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Bullous Pemphigoid and Cicatricial Pemphigoid Autoantibodies React with Ultrastructurally Separable Epitopes on the BP180 Ectodomain: Evidence that BP180 Spans the Lamina Lucida [PDF]

Journal of Investigative Dermatology, 1997
The BP180 antigen is a hemidesmosomal glycoprotein that is recognized by autoantibodies associated with three autoimmune disorders, bullous pemphigoid (BP), herpes gestationis (HG), and cicatricial pemphigoid (CP).
Catherine Prost, Eady, Robin A.J., James R. McMillan, Prost, Catherine, Giudice, George J., Bédane, Christophe, McMillan, James R., Bernard, Philippe, Bonnetblanc, Jean-Marie, Balding, Shawn D., Jean-Marie Bonnetblanc, Shawn D. Balding, Christophe Bédane, George J. Giudice, Luis A. Diaz, Robin A.J. Eady, Philippe Bernard, Diaz, Luis A.   +17 more
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Oral pemphigoid autoantibodies preferentially target BP180 ectodomain

Clinical Immunology, 2007
Mucous membrane pemphigoid (MMP) comprises a heterogenous group of autoimmune subepithelial bullous diseases very frequently having oral involvement. Very few studies have investigated the immunological status of a subset of MMP, termed oral pemphigoid ...
TIRONE, F., ZAMBRUNO, G., CARROZZO, M., BERTOLUSSO, G., COZZANI, EMANUELE CLAUDIO, DI ZENZO, G., CALABRESI, V., PARODI, AURORA, ARDUINO, P.   +8 more
core   +7 more sources