Results 31 to 40 of about 3,264 (192)

Insights Into the Pathogenesis of Bullous Pemphigoid: The Role of Complement-Independent Mechanisms

Frontiers in Immunology, 2022
Bullous pemphigoid is an autoimmune blistering disease caused by autoantibodies targeting BP180 and BP230. While deposits of IgG and/or complement along the epidermal basement membrane are typically seen suggesting complement -mediated pathogenesis ...
Connor Cole, Keshavamurthy Vinay, Luca Borradori, Kyle T. Amber, Kyle T. Amber   +4 more
doaj   +1 more source

BP180 Autoantibodies Target Different Epitopes in Multiple Sclerosis or Alzheimer’s Disease than in Bullous Pemphigoid [PDF]

, 2019
Neurologic patients have an increased risk for bullous pemphigoid (BP), in which autoantibodies target BP180, a cutaneous basement membrane protein also expressed in the brain. Here we show that 53.6% of sera from patients with multiple sclerosis (MS) (n
Remes, Anne M, Remes, Anne M., Herukka, Sanna-Kaisa, Tuusa, Jussi, Kokkonen, Nina, Huilaja, Laura, Izumi, Kentaro, Miettunen, Jouko, Tertsunen, Hanna-Mari, Shimizu, Hiroshi, Tasanen, Kaisa, Lindgren, Outi, Nishie, Wataru   +12 more
core   +2 more sources

Use of gliptins reduces levels of SDF-1/CXCL12 in bullous pemphigoid and type 2 diabetes, but does not increase autoantibodies against BP180 in diabetic patients

Frontiers in Immunology, 2022
The use of dipeptidyl peptidase 4 (DPP4) inhibitors, (also known as gliptins), is associated with an increased risk of bullous pemphigoid (BP), an autoimmune blistering skin disease.
Antti Nätynki, Päivi Leisti, Jussi Tuusa, Outi Varpuluoma, Laura Huilaja, Kentaro Izumi, Sanna-Kaisa Herukka, Olavi Ukkola, Juhani Junttila, Nina Kokkonen, Kaisa Tasanen   +10 more
doaj   +1 more source

Autoantibodies Against the Immunodominant Bullous Pemphigoid Epitopes Are Rare in Patients With Dermatitis Herpetiformis and Coeliac Disease

Frontiers in Immunology, 2020
Dermatitis herpetiformis (DH) is an extraintestinal manifestation of coeliac disease (CD). Patients with DH have an elevated risk of development of another autoimmune blistering skin disease, bullous pemphigoid (BP). In this study we investigated whether
Antti Nätynki, Jussi Tuusa, Kaisa Hervonen, Kaisa Hervonen, Katri Kaukinen, Katri Kaukinen, Outi Lindgren, Outi Lindgren, Laura Huilaja, Nina Kokkonen, Teea Salmi, Teea Salmi, Kaisa Tasanen   +12 more
doaj   +1 more source

A Cross-Sectional Study Comparing the Prevalence of Bullous Pemphigoid Autoantibodies in 275 Cases of Type II Diabetes Mellitus Treated With or Without Dipeptidyl Peptidase-IV Inhibitors

Frontiers in Immunology, 2019
Background: Anti-hyperglycemic drug dipeptidyl peptidase-IV inhibitors (DPP-4i) have recently been recognized as bullous pemphigoid (BP) inducing drugs. It remains uncertain whether DPP-4i induce BP-IgG autoantibodies before the onset of BP.Objective: To
Kentaro Izumi, Wataru Nishie, Mutsuo Beniko, Hiroshi Shimizu   +3 more
doaj   +1 more source

Bullous Pemphigoid IgG Induces BP180 Internalization via a Macropinocytic Pathway [PDF]

, 2013
Bullous pemphigoid (BP) is an autoimmune blistering skin disease induced by pathogenic autoantibodies against a type II transmembrane protein (BP180, collagen type XVII, or BPAG2).
Jones, Jonathan C.R., Ishii, Masamitsu, Yasuo Kitajima, Kitajima, Yasuo, Hiromi Kobayashi, Jonathan C.R. Jones, Toshiyuki Ozawa, Daisuke Tsuruta, Sho Hiroyasu, Yumi Aoyama, Aoyama, Yumi, Ozawa, Toshiyuki, Tsuruta, Daisuke, Kobayashi, Hiromi, Takashi Hashimoto, Masamitsu Ishii, Hiroyasu, Sho, Hashimoto, Takashi   +17 more
core   +1 more source

Case report: Bullous pemphigoid arising in a patient with scleroderma and multiple sclerosis

Frontiers in Medicine, 2022
BackgroundBullous pemphigoid (BP) is the most common autoimmune-blistering disease, clinically characterized by erythematous urticarial plaques, blisters, and intense pruritus, induced by autoantibodies against two proteins of the dermo-epidermal ...
Francesco Moro, Francesco Moro, Feliciana Mariotti, Anna Pira, Naomi De Luca, Biagio Didona, Gianluca Pagnanelli, Giovanni Di Zenzo   +7 more
doaj   +1 more source

Type XVII collagen (BP180) and LAD-1 are present as separate trimeric complexes [PDF]

, 1999
This study characterized the high molecular mass BP180 complex that is observed when unheated sodium dodecyl sulfate extracts of human skin or keratinocytes are subjected to sodium dodecyl sulfate-polyacrylamide gel electrophoresis and immunoblotting. In
Nijenhuis, Albertine, Pas, HH, de Jong, MCJM, Kloosterhuis, GJ, Jonkman, MF, van der Meer, JB   +5 more
core   +3 more sources

Dipeptidyl peptidase IV inhibitor-associated bullous pemphigoid: a recently recognized autoimmune blistering disease with unique clinical, immunological and genetic characteristics

Immunological Medicine, 2019
Bullous pemphigoid (BP) is an organ-specific autoantibody-mediated autoimmune blistering skin disorder that tends to affect the elderly. Tense blister formation associated with itchy urticarial erythema is clinically observed in BP, and subepidermal ...
Wataru Nishie
doaj   +1 more source

Human eosinophils express the high affinity IgE receptor, FcεRI, in bullous pemphigoid.

PLoS ONE, 2014
Bullous pemphigoid (BP) is an autoimmune blistering disease mediated by autoantibodies targeting BP180 (type XVII collagen). Patient sera and tissues typically have IgG and IgE autoantibodies and elevated eosinophil numbers. Although the pathogenicity of
Kelly N Messingham, Heather M Holahan, Alexandra S Frydman, Colleen Fullenkamp, Rupasree Srikantha, Janet A Fairley   +5 more
doaj   +1 more source