Results 21 to 30 of about 3,264 (192)

The dysfunction of BP180/collagen XVII in keratinocytes promotes melanoma progression [PDF]

Oncogene, 2019
BP180, also termed collagen XVII, is a hemidesmosomal transmembrane glycoprotein expressed in basal keratinocytes, and functions as a cell-matrix adhesion molecule in the dermal-epidermal junction of the skin.
Li, Ning, Williams, Scott, Shan, Yue, Liu, Zhi, Brozowski, Jaime M, Liu, Zhen, Su, Maureen, Lough, Kendall, Zhang, Yang, Hwang, Bin-Jin, Burette, Susan, Chen, Jinbo, Smith, Christof C, Thomas, Nancy E, Googe, Paul   +14 more
core   +6 more sources

Preferential Reactivity of Dipeptidyl Peptidase-IV Inhibitor-Associated Bullous Pemphigoid Autoantibodies to the Processed Extracellular Domains of BP180 [PDF]

Frontiers in Immunology, 2019
Bullous pemphigoid (BP) is a common autoimmune blistering disease in which autoantibodies target the hemidesmosomal components BP180 and/or BP230 in basal keratinocytes.
Yosuke Mai, Wataru Nishie, Kentaro Izumi, Hiroshi Shimizu   +3 more
doaj   +2 more sources

Cloning and Primary Structural Analysis of the Bullous Pemphigoid Autoantigen BP180 [PDF]

Journal of Investigative Dermatology, 1992
Bullous pemphigoid (BP) is an autoimmune skin disease that is characterized by the presence of subepidermal blisters resulting from a disruption of the adhesive interactions between basal keratinocytes and the cutaneous basement membrane.
Emery, Daryl J, Daryl J Emery, Giudice, George J, George J Giudice, Diaz, Luis A, Luis A Diaz   +5 more
core   +3 more sources

The significance of preclinical anti-BP180 autoantibodies

Frontiers in Immunology, 2022
Bullous pemphigoid (BP) is the most common autoimmune subepidermal blistering disease. Although the pathomechanism of BP onset has yet to be elucidated in detail, BP autoantibodies targeting two hemidesmosomal components, BP180 and BP230, are known to play a pivotal role in BP pathogenesis.
Yosuke Mai, Kentaro Izumi, Shoko Mai, Hideyuki Ujiie   +3 more
openaire   +3 more sources

Analysis of the autoimmune response against BP180 in patients with Alzheimer’s disease [PDF]

Annals of Translational Medicine, 2021
Current epidemiological studies suggest a significant correlation between Alzheimer's disease (AD) and bullous pemphigoid (BP). However, the autoimmune response against BP180 in patients with AD has not been fully understood. investigated.We randomly enrolled 48 patients with AD and 50 sex- and age-matched healthy controls.
Wang, Ya-Nan, Hammers, Christoph M., Mao, Xuming, Jin, Hong-Zhong, Yuan, Jing, Li, Li   +5 more
openaire   +2 more sources

BP180 Is a Prognostic Factor in Head and Neck Squamous Cell Carcinoma [PDF]

Anticancer Research, 2021
Prognosis plays a vital role in head and neck squamous cell carcinoma (HNSCC) patient management and decision-making. This study aimed to identify the role of BP180 as a prognostic factor in HNSCC.Protein expression of bullous pemphigoid antigen II (BP180) was verified by immunohistochemistry (IHC) in a tissue microarray study of 202 cases.IHC analysis
Xue, Meng, Fumihiko, Matsumoto, Taisuke, Mori, Nami, Miura, Yoshinori, Ino, Kaoru, Onidani, Kenya, Kobayashi, Yusuke, Matsuzaki, Seiichi, Yoshimoto, Katsuhisa, Ikeda, Kazufumi, Honda   +10 more
openaire   +2 more sources

Autoreactive Peripheral Blood T Helper Cell Responses in Bullous Pemphigoid and Elderly Patients With Pruritic Disorders

Frontiers in Immunology, 2021
Bullous pemphigoid (BP) is a prototypic autoimmune disorder of the elderly, characterized by serum IgG autoantibodies, namely anti-BP180 and anti-BP230, directed against components of the basal membrane zone that lead to sub-epidermal loss of adhesion ...
Dario Didona, Luca Scarsella, Milad Fehresti, Farzan Solimani, Farzan Solimani, Hazem A. Juratli, Manuel Göbel, Stefan Mühlenbein, Lily Holiangu, Josquin Pieper, Vera Korff, Thomas Schmidt, Cassian Sitaru, Rüdiger Eming, Michael Hertl, Robert Pollmann   +15 more
doaj   +1 more source

A role for anti‐BP180 autoantibodies in chronic rhinosinusitis [PDF]

The Laryngoscope, 2013
Objectives/HypothesisChronic Rhinosinusitis (CRS) is accompanied by evidence of a vigorous adaptive immune response, and emerging studies demonstrate that some nasal polyps manifest a polyclonal autoantibody response. We previously found that antibodies against BP180, a component of the hemidesmosome complex and the dominant epitope in autoimmune ...
Jill S, Jeffe, Sudarshan, Seshadri, Kevin J, Hamill, Julia He, Huang, Roderick, Carter, Lydia, Suh, Kathryn E, Hulse, James, Norton, David B, Conley, Rakesh K, Chandra, Robert C, Kern, Jonathan C R, Jones, Robert P, Schleimer, Bruce K, Tan   +13 more
openaire   +2 more sources

Rapid Disease Control in First-Line Therapy-Resistant Mucous Membrane Pemphigoid and Bullous Pemphigoid with Omalizumab as Add-On Therapy: A Case Series Of 13 Patients

Frontiers in Immunology, 2022
The role of IgE autoantibodies has been demonstrated in the pathogenesis of bullous pemphigoid for many years. Recently, omalizumab (OMZ), a humanized monoclonal anti-IgE antibody that depletes total serum IgE, has been used off-label in a few case ...
Marina Alexandre, Gérôme Bohelay, Gérôme Bohelay, Thomas Gille, Thomas Gille, Christelle Le Roux-Villet, Isaac Soued, Florence Morin, Frédéric Caux, Frédéric Caux, Sabine Grootenboer-Mignot, Catherine Prost-Squarcioni, Catherine Prost-Squarcioni, Catherine Prost-Squarcioni   +13 more
doaj   +1 more source

Super‐resolution imaging detects BP180 autoantigen in immunoglobulin M pemphigoid [PDF]

, 2022
Bullous pemphigoid is generally caused by immunoglobulin (Ig)G autoantibodies against hemidesmosomal BP180 and/or BP230. Recently, the concept of IgM pemphigoid has been proposed.
Tsujuwaki, Masumi, Mai, Yosuke, Ujiie, Hideyuki, Hirano, Yoko, Mai, Shoko, Imafuku, Keisuke, Yosuke Mai, Hideyuki Ujiie, Yoko Hirano, Hiroshi Koga, Shoko Mai, Izumi, Kentaro, Hiroaki Iwata, Iwata, Hiroaki, Koga, Hiroshi, Kentaro Izumi, Keisuke Imafuku, Masumi Tsujuwaki   +17 more
core   +1 more source