Results 41 to 50 of about 3,264 (192)

Are Anti-BP180 IgG1 or IgG4 Autoantibodies Pathogenic? [PDF]

Journal of Investigative Dermatology, 2002
Bullous pemphigoid (BP) is an acquired autoimmune skin disease characterized by autoantibodies against two hemidesmosomal antigens, BP230 (BPAG1) and BP180 (BPAG2) and subepidermal blisters (Stanley et al, 1981; Diaz et al, 1990; Stanley, 1999). In the skin lesions of these patients basal keratinocytes detach from the underlying dermis at the level of ...
openaire   +2 more sources

Deciphering the Contribution of BP230 Autoantibodies in Bullous Pemphigoid

Antibodies, 2022
Bullous pemphigoid (BP) is a subepidermal autoimmune blistering disease predominantly affecting elderly patients and carries significant morbidity and mortality.
Connor Cole, Luca Borradori, Kyle T. Amber   +2 more
doaj   +1 more source

Oral pemphigoid autoantibodies preferentially target BP180 ectodomain

Mucous membrane pemphigoid (MMP) comprises a heterogenous group of autoimmune subepithelial bullous diseases very frequently having oral involvement. Very few studies have investigated the immunological status of a subset of MMP, termed oral pemphigoid ...
Calabresi V, Bertolusso G, Carrozzo M, Tirone F, Cozzani E, Zambruno G, Parodi A, Di Zenzo G, Arduino P   +8 more
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Serological Insights into Bullous Pemphigoid: Comparative Diagnostic Performance and Their Association with Clinical Severity

Clinical Dermatology Review
Background: Bullous pemphigoid (BP) is an autoimmune subepidermal blistering disease caused by autoantibodies targeting BP180 and BP230. We evaluated the diagnostic performance of anti-BP180-NC16A and anti-BP230 enzyme-linked immunosorbent assay (ELISA ...
Mohan Shendre, Tejashwini B, Chanabasappa Mendagudli, Sushma HR, Mitaxari Hugar, Shivakumar Belur   +5 more
doaj   +1 more source

How Does Intramolecular Epitope Spreading Occur in BPAG2 (BP180)? [PDF]

Journal of Investigative Dermatology, 2010
Several studies have suggested that autoantibodies directed against multiple epitopes occur via epitope spreading in autoimmune bullous skin diseases. However, the precise sequence of events in epitope spreading has not been elucidated for any of the epidermal autoantigens. In this issue, using a transgenic mouse model, Di Zenzo et al.
Hashimoto, Takashi, Hamada, Takahiro, Dainichi, Teruki, Ishii, Norito, Karashima, Tadashi, Nakama, Takekuni, Yasumoto, Shinichiro   +6 more
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Case Report: Prurigo nodularis-like linear IgA/IgG bullous dermatosis: a case report and literature review

Frontiers in Immunology, 2023
Linear IgA/IgG bullous dermatosis (LAGBD) is a rare autoimmune subepidermal bullous disorder characterized by linear deposition of concurrent IgA and IgG autoantibodies along the basement membrane zone (BMZ). The clinical features of LAGBD can be diverse,
Yuxi Zhou, Xingli Zhou, Xun Feng, Dengmei Xia, Hua Qian, Hongjie Liu, Xiaoguang Li, Wei Li   +7 more
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The intracellular domain of BP180/collagen XVII is intrinsically disordered and partially folds in an anionic membrane lipid-mimicking environment [PDF]

, 2020
The trimeric transmembrane collagen BP180, also known as collagen XVII, is an essential component of hemidesmosomes at the dermal–epidermal junction and connects the cytoplasmic keratin network to the extracellular basement membrane. Dysfunction of BP180
Ruskamo, Salla, Koski, M. Kristian, Tasanen, Kaisa, Tuusa, Jussi   +3 more
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Case Report: The many faces of bullous pemphigoid

Frontiers in Immunology, 2023
The pemphigoid group comprises a number of bullous skin diseases with autoantibodies against different constituents of the basement membrane zone that result in subepidermal detachment and clinically characteristic tense blisters, erosions, urticarial ...
Laura Rechtien, Laura Rechtien, Lukas Sollfrank, Lukas Sollfrank, Yannick Foerster, Yannick Foerster, Carola Berking, Carola Berking, Michael Sticherling, Michael Sticherling   +9 more
doaj   +1 more source

Immunological and Statistical Studies of Anti-BP180 Antibodies in Paraneoplastic Pemphigus [PDF]

Journal of Investigative Dermatology, 2014
Abbreviations: BMZ, basement membrane zone; BP, bullous pemphigoid; HaCaT, concentrated culture supernatant of HaCaT cells; IB, immunoblotting; IF, immunofluorescence; PNP, paraneoplastic pemphigus; RP, recombinant ...
Tsuchisaka, Atsunari, Kawano, Hideo, Yasukochi, Atsushi, Teye, Kwesi, Ishii, Norito, Koga, Hiroshi, Sogame, Ryosuke, Ohzono, Ayaka, Krol, Rafal P., Kawakami, Tamihiro, Furumura, Minao, Ohata, Chika, Li, Xiaoguang, Hashimoto, Takashi   +13 more
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Mixed muco-cutaneous pemphigoid: Clinical and immunological features of 15 cases

Frontiers in Immunology, 2023
IntroductionWe describe a series of patients whose auto-immune bullous skin disease (AIBD) of the dermal-epidermal junction (DEJ) was characterized by clinical, immunological and ultrastructural features intermediate between bullous pemphigoid (BP) and ...
Raphaël Janela, Norito Ishii, Marion Castel, Fabienne Jouen, Lucie Cellier, Philippe Courville, Pascal Joly, Pascal Joly, Vivien Hébert, Vivien Hébert   +9 more
doaj   +1 more source