Results 81 to 90 of about 323,451 (283)

Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells

open access: yesMolecular Oncology, EarlyView.
We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller   +17 more
wiley   +1 more source

More than Likes: A Mediation and Moderation Model of Consumer Brand Preference and Awareness Among Gen Z Coffee Shop Consumers in Saudi Arabia

open access: yesTourism and Hospitality
Background: In an increasingly digital marketplace, social media marketing activities (SMMAs) have become vital for building consumer–brand relationships, particularly among Generation Z (Gen Z) consumers. Coffee shops offer a unique context because they
Ahmed Hassan Abdou
doaj   +1 more source

The influence of customer based brand ekvity on customer responses – the newly opened West Hill Mall in Ghana [PDF]

open access: yesTrendy v podnikání, 2016
The interest of this study is to understand customer based brand equity and its effect on consumers’ willingness to pay price premiums, consumers’ attitude towards brand preference and purchase intention at the newly open West Hills Mall in Ghana.
Amegbe Hayford
doaj  

A Comparative Study on Indonesian and Malaysian Consumers’ Perception and Preference Towards Handphones From China, South Korea, America, and Europe

open access: yesIndonesian Journal of Business and Entrepreneurship, 2018
Most handphones in Indonesia and Malaysia are imported from other countries such as from America, Europe, China, and South Korea. The enhancement of global brands has reduced local brand preferences.
Silvia Dewi Sagita Andik   +2 more
doaj   +1 more source

Recurrent cancer‐associated ERBB4 mutations are transforming and confer resistance to targeted therapies

open access: yesMolecular Oncology, EarlyView.
We show that the majority of the 18 analyzed recurrent cancer‐associated ERBB4 mutations are transforming. The most potent mutations are activating, co‐operate with other ERBB receptors, and are sensitive to pan‐ERBB inhibitors. Activating ERBB4 mutations also promote therapy resistance in EGFR‐mutant lung cancer.
Veera K. Ojala   +15 more
wiley   +1 more source

Crucial parameters for precise copy number variation detection in formalin‐fixed paraffin‐embedded solid cancer samples

open access: yesMolecular Oncology, EarlyView.
This study shows that copy number variations (CNVs) can be reliably detected in formalin‐fixed paraffin‐embedded (FFPE) solid cancer samples using ultra‐low‐pass whole‐genome sequencing, provided that key (pre)‐analytical parameters are optimized.
Hanne Goris   +10 more
wiley   +1 more source

Does brand image or taste have more influence on consumer preference for energy drinks? [PDF]

open access: yes, 2009
In the past, numerous studies have been completed comparing brand image to product performance. In these studies it has been shown that brand image does have an effect on preferences and observers evaluate product performance differently when brand image
Moore, Matthew
core   +1 more source

Combining antibody conjugates with cytotoxic and immune‐stimulating payloads maximizes anti‐cancer activity

open access: yesMolecular Oncology, EarlyView.
Methods to improve antibody–drug conjugate (ADC) treatment durability in cancer therapy are needed. We utilized ADCs and immune‐stimulating antibody conjugates (ISACs), which are made from two non‐competitive antibodies, to enhance the entry of toxic payloads into cancer cells and deliver immunostimulatory agents into immune cells.
Tiexin Wang   +3 more
wiley   +1 more source

Product Variety under Brand Influence: An Empirical Investigation of Personal Computer Demand [PDF]

open access: yes
Prior research suggests that brand may influence consumer preference for differentiated products. However, the extant literature does not measure how brand value affects product similarity and consumer choice.
Kai-Lung HUI
core  

Intelligent Product Brokering for E-Commerce: An Incremental Approach to Unaccounted Attribute Detection [PDF]

open access: yes, 2004
This research concentrates on designing generic product-brokering agent to understand user preference towards a product category and recommends a list of products to the user according to the preference captured by the agent.
Guan   +4 more
core   +2 more sources

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