Results 151 to 160 of about 95,123 (282)

A transcription‐independent mechanism determines rapid periodic fluctuations of BRCA1  expression [PDF]

, 2023
Chen Nie, Xiao Albert Zhou, Jiadong Zhou, Zelin Liu, Yangyang Gu, Wanchang Liu, Jun Zhan, Shiwei Li, Yundong Xiong, Mei Zhou, Qinjian Shen, Weibin Wang, Ence Yang, Jiadong Wang   +13 more
openalex   +1 more source

Multiplexed Transcriptomics for Screening Drug Combinations and Defining the Mechanism of Action of HCC Therapeutics at Single‐Cell Resolution

Cell Proliferation, EarlyView.
We designed a framework for screening clinical drug combinations with anti‐hepatocellular carcinoma (HCC) activity, comprising four parts: primary screening, single‐cell screening, functional validation, and mechanism research. High‐throughput single‐cell screening identifies HY (HHT and YM155) as a potent anti‐HCC drug combination, validated by in ...
Mengmeng Jiang, Haide Chen, Guoxia Wen, Yuqing Mei, Wenzhao Zhou, Bin Xu, Tingyue Zhang, Guangyan Li, Junqing Wu, Xiaoping Han, Xudong Fu, Guoji Guo, Jingjing Wang   +12 more
wiley   +1 more source

A Comprehensive and Accessible Model for Co-Segregation Analysis in BRCA1, BRCA2 , and PALB2 Variant Classification [PDF]

Setareh Moghadasi, Ramin Monajemi, Merel E. Braspenning, Maaike P.G. Vreeswijk, Mar Rodriguez Girondo   +4 more
openalex   +1 more source

Breaking down BRCA1 [PDF]

Nature Genetics, 1994
openaire   +2 more sources

Molecular pathology of phyllodes tumours of the breast—much more than MED12

Histopathology, EarlyView.
Phyllodes tumours can develop from fibroadenomas bearing MED12 variants by the development of pTERT alterations (“MED12 pathway”) or de novo (“MED12 independent pathway”). Grade progression is associated with increasing genetic complexity including cancer driver gene aberrations. Molecular alterations can be useful in assigning grade and distinguishing
Jia‐Min B Pang, Kylie L Gorringe, Puay Hoon Tan, Stephen B Fox   +3 more
wiley   +1 more source

Skin Cancer Predisposition Genes, Full‐Body Skin Examinations, Familial Disclosure, and Genetic Testing Among High‐Risk Individuals

International Journal of Dermatology, EarlyView.
ABSTRACT Background There is a lack of knowledge in full‐body skin examinations (FBSEs) in the context of pathogenic or likely pathogenic variants (PV/LPV) in skin cancer predisposition genes (CPGs). This study assessed the association between carrier status of PV/LPV in skin CPGs and FBSEs and described the patterns of family letter receipt, familial ...
Jincong Q. Freeman, Yu Matsui, Fangyuan Zhao, Olufunmilayo I. Olopade, Dezheng Huo   +4 more
wiley   +1 more source

Conditional in vivo deletion of LYN kinase has little effect on a BRCA1 loss-of-function-associated mammary tumour model

Disease Models & Mechanisms
Giusy Tornillo, Lauren Warrington, Howard Kendrick, Adam T. Higgins, Trevor Hay, Sam Beck, Matthew J. Smalley   +6 more
doaj   +1 more source

An Inducible BRCA1 Expression System with In Vivo Applicability Uncovers Activity of the Combination of ATR and PARP Inhibitors to Overcome Therapy Resistance. [PDF]

Cancers (Basel)
Irving E, Morcavallo A, Vohhodina-Tretjakova J, Wijnhoven PWG, Beckett AL, Jacques MP, Evans RS, Moss JI, Staniszewska AD, Forment JV.   +9 more
europepmc   +1 more source

Vaginal Microbiota and Ovarian Cancer: A New Frontier in Immunomodulation and Diagnosis

Immunology, EarlyView.
Microbial imbalance, dysbiosis, plays a role in ovarian carcinogenesis by interacting with the immune system and altering inflammatory pathways, notably Th17 pathways. In contrast, eubiosis, characterised by Lactobacillus dominance, protects against infections and maintains hormone metabolism.
Wafa Babay, Mariem Garci, Ahmed Baligh Laaribi, Nabil Mathlouthi, Imene Ouzari   +4 more
wiley   +1 more source

Updated analysis of pathogenic variants in BRCA1/BRCA2 among the general Japanese population. [PDF]

Hum Genome Var
Mariya T, Idogawa M, Saito T, Nakase H, Tokino T, Sakurai A.   +5 more
europepmc   +1 more source