Results 11 to 20 of about 14,160 (163)

Comparison of static and microfluidic protease assays using modified bioluminescence resonance energy transfer chemistry.

PLoS ONE, 2014
BackgroundFluorescence and bioluminescence resonance energy transfer (F/BRET) are two forms of Förster resonance energy transfer, which can be used for optical transduction of biosensors.
Nan Wu, Helen Dacres, Alisha Anderson, Stephen C Trowell, Yonggang Zhu   +4 more
doaj   +1 more source

NanoBRET: The Bright Future of Proximity-Based Assays

Frontiers in Bioengineering and Biotechnology, 2019
Bioluminescence resonance energy transfer (BRET) is a biophysical technique used to monitor proximity within live cells. BRET exploits the naturally occurring phenomenon of dipole-dipole energy transfer from a donor enzyme (luciferase) to an acceptor ...
Natasha C. Dale, Natasha C. Dale, Natasha C. Dale, Elizabeth K. M. Johnstone, Elizabeth K. M. Johnstone, Elizabeth K. M. Johnstone, Carl W. White, Carl W. White, Carl W. White, Kevin D. G. Pfleger, Kevin D. G. Pfleger, Kevin D. G. Pfleger, Kevin D. G. Pfleger   +12 more
doaj   +1 more source

Integration of Nanomaterials and Bioluminescence Resonance Energy Transfer Techniques for Sensing Biomolecules

Biosensors, 2019
Bioluminescence resonance energy transfer (BRET) techniques offer a high degree of sensitivity, reliability and ease of use for their application to sensing biomolecules.
Eugene Hwang, Jisu Song, Jin Zhang
doaj   +1 more source

A Deep Learning Framework for Early Detection of Potential Cardiac Anomalies via Murmur Pattern Analysis in Phonocardiograms

Engineering Proceedings
Heart murmurs, resulting from turbulent blood flow within the cardiac structure, represent some of the initial acoustic manifestations of potential underlying cardiovascular anomalies, such as arrhythmias. This research presents a deep learning framework
Aymane Edder, Fatima-Ezzahraa Ben-Bouazza, Oumaima Manchadi, Youssef Ait Bigane, Djeneba Sangare, Bassma Jioudi   +5 more
doaj   +1 more source

Self Attention-Driven ECG Denoising: A Transformer-Based Approach for Robust Cardiac Signal Enhancement

Signals
The analysis of electrocardiogram (ECG) signals is profoundly affected by the presence of electromyographic (EMG) noise, which can lead to substantial misinterpretations in healthcare applications.
Aymane Edder, Fatima-Ezzahraa Ben-Bouazza, Idriss Tafala, Oumaima Manchadi, Bassma Jioudi   +4 more
doaj   +1 more source

Mathematical Models for Quantitative Assessment of Bioluminescence Resonance Energy Transfer (BRET): Application to Seven Transmembrane Receptors (7TMRs) Oligomerization

Frontiers in Endocrinology, 2012
The idea that seven transmembrane receptors (7TMRs; also designated G-protein coupled receptors (GPCRs)) might form dimers or higher order oligomeric complexes was formulated more than 20 years ago and has been intensively studied since then. In the last
Luka eDrinovec, Valentina eKubale, Jane eNøhr Larsen, Milka eVrecl   +3 more
doaj   +1 more source

Internalization dissociates β2-adrenergic receptors. [PDF]

PLoS ONE, 2011
G protein-coupled receptors (GPCRs) self-associate as dimers or higher-order oligomers in living cells. The stability of associated GPCRs has not been extensively studied, but it is generally thought that these receptors move between the plasma membrane ...
Tien-Hung Lan, Sudhakiranmayi Kuravi, Nevin A Lambert   +2 more
doaj   +1 more source

A Multimodal Deep Learning Pipeline for Enhanced Detection and Classification of Oral Cancer

Engineering Proceedings
Oral cancer represents a life-threatening malignancy with profound implications for patient survival and quality of life. Oral squamous cell carcinoma (OSCC), the predominant histological variant of oral cancer, constitutes a substantial healthcare ...
Idriss Tafala, Fatima-Ezzahraa Ben-Bouazza, Manal Chakour El Mezali, Ilyass Emssaad, Bassma Jioudi   +4 more
doaj   +1 more source

Predictive Maintenance in Pharma Manufacturing: Challenges and Strategic Directions

Engineering Proceedings
Predictive maintenance (PdM) has emerged as a critical enabler for improving reliability, operational efficiency, and regulatory compliance in pharmaceutical manufacturing.
Oumaima Manchadi, Fatima-Ezzahraa Ben-Bouazza, Aymane Edder, Idriss Tafala, Bassma Jioudi   +4 more
doaj   +1 more source

Trustworthy Multimodal AI Agents for Early Breast Cancer Detection and Clinical Decision Support

Engineering Proceedings
Timely and precise identification of breast cancer is crucial for enhancing clinical outcomes; however, current AI systems frequently exhibit deficiencies in transparency, trustworthiness, and the capacity to assimilate varied data modalities.
Ilyass Emssaad, Fatima-Ezzahraa Ben-Bouazza, Idriss Tafala, Manal Chakour El Mezali, Bassma Jioudi   +4 more
doaj   +1 more source