Results 21 to 30 of about 39,288 (183)

Bioluminescence Resonance Energy Transfer Reveals the Adrenocorticotropin (ACTH)-Induced Conformational Change of the Activated ACTH Receptor Complex in Living Cells [PDF]

, 2011
Bioluminescence resonance energy transfer analysis is used to study the interaction between melanocortin 2 receptor (MC2R) accessory protein and the MC2R and provides evidence for protein kinase A-dependent conformational changes in the receptor complex ...
Adrian J. L. Clark, Szidonya, L, Laszlo Szidonya, Cooray, SN, Mazhar, K, Teng-Teng Chung, Clark, AJ, Khansa Mazhar, Chung, TT, Sadani N. Cooray   +9 more
core   +1 more source

Differential Water Networks Guide Selectivity Optimization of a Cell Active BPTF Inhibitor in Neuroblastoma

Angewandte Chemie, EarlyView.
BZ2 is a second‐generation Bromodomain PHD finger Transcription Factor (BPTF) inhibitor with improved selectivity over Class I and Class IV BRD off‐targets identified in our previously reported inhibitor, BZ1. Structural analyses reveal that water network engagement is key to this selectivity.
Kesavan Babu, Chun‐Ju Tsou, Sourav Das, Liying Fan, Anasuya Pal, Molly Sneddon, Timothy R. Stachowski, Priyanka Samanta, Stanley Nithianantham, Caroline Buchholz, Shi Zhang, Xiang Fu, Rahul S. Kathayat, Wenwei Lin, Yongtao Li, Lei Yang, Taosheng Chen, Marcus Fischer, Anang A. Shelat, William C. K. Pomerantz   +19 more
wiley   +2 more sources

Bret Michael: A Biography [PDF]

, 2011
A professor of the computer science and electrical engineering, Bret Michael joined the faculty of the Naval Postgraduate School in 1998. He received the 2010 Engineer of the Year Award from the Reliability Society of the Institute of Electrical and ...
Michael, Bret
core   +2 more sources

NanoBRET: The Bright Future of Proximity-Based Assays

Frontiers in Bioengineering and Biotechnology, 2019
Bioluminescence resonance energy transfer (BRET) is a biophysical technique used to monitor proximity within live cells. BRET exploits the naturally occurring phenomenon of dipole-dipole energy transfer from a donor enzyme (luciferase) to an acceptor ...
Natasha C. Dale, Natasha C. Dale, Natasha C. Dale, Elizabeth K. M. Johnstone, Elizabeth K. M. Johnstone, Elizabeth K. M. Johnstone, Carl W. White, Carl W. White, Carl W. White, Kevin D. G. Pfleger, Kevin D. G. Pfleger, Kevin D. G. Pfleger, Kevin D. G. Pfleger   +12 more
doaj   +1 more source

Integration of Nanomaterials and Bioluminescence Resonance Energy Transfer Techniques for Sensing Biomolecules

Biosensors, 2019
Bioluminescence resonance energy transfer (BRET) techniques offer a high degree of sensitivity, reliability and ease of use for their application to sensing biomolecules.
Eugene Hwang, Jisu Song, Jin Zhang
doaj   +1 more source

A Deep Learning Framework for Early Detection of Potential Cardiac Anomalies via Murmur Pattern Analysis in Phonocardiograms

Engineering Proceedings
Heart murmurs, resulting from turbulent blood flow within the cardiac structure, represent some of the initial acoustic manifestations of potential underlying cardiovascular anomalies, such as arrhythmias. This research presents a deep learning framework
Aymane Edder, Fatima-Ezzahraa Ben-Bouazza, Oumaima Manchadi, Youssef Ait Bigane, Djeneba Sangare, Bassma Jioudi   +5 more
doaj   +1 more source

Self Attention-Driven ECG Denoising: A Transformer-Based Approach for Robust Cardiac Signal Enhancement

Signals
The analysis of electrocardiogram (ECG) signals is profoundly affected by the presence of electromyographic (EMG) noise, which can lead to substantial misinterpretations in healthcare applications.
Aymane Edder, Fatima-Ezzahraa Ben-Bouazza, Idriss Tafala, Oumaima Manchadi, Bassma Jioudi   +4 more
doaj   +1 more source

Mathematical Models for Quantitative Assessment of Bioluminescence Resonance Energy Transfer (BRET): Application to Seven Transmembrane Receptors (7TMRs) Oligomerization

Frontiers in Endocrinology, 2012
The idea that seven transmembrane receptors (7TMRs; also designated G-protein coupled receptors (GPCRs)) might form dimers or higher order oligomeric complexes was formulated more than 20 years ago and has been intensively studied since then. In the last
Luka eDrinovec, Valentina eKubale, Jane eNøhr Larsen, Milka eVrecl   +3 more
doaj   +1 more source

Internalization dissociates β2-adrenergic receptors. [PDF]

PLoS ONE, 2011
G protein-coupled receptors (GPCRs) self-associate as dimers or higher-order oligomers in living cells. The stability of associated GPCRs has not been extensively studied, but it is generally thought that these receptors move between the plasma membrane ...
Tien-Hung Lan, Sudhakiranmayi Kuravi, Nevin A Lambert   +2 more
doaj   +1 more source

A Multimodal Deep Learning Pipeline for Enhanced Detection and Classification of Oral Cancer

Engineering Proceedings
Oral cancer represents a life-threatening malignancy with profound implications for patient survival and quality of life. Oral squamous cell carcinoma (OSCC), the predominant histological variant of oral cancer, constitutes a substantial healthcare ...
Idriss Tafala, Fatima-Ezzahraa Ben-Bouazza, Manal Chakour El Mezali, Ilyass Emssaad, Bassma Jioudi   +4 more
doaj   +1 more source