Results 41 to 50 of about 39,288 (183)

Setting up a Bioluminescence Resonance Energy Transfer high throughput screening assay to search for protein/protein interaction inhibitors in mammalian cells.

Frontiers in Endocrinology, 2012
Each step of the cell life and its response or adaptation to its environment are mediated by a network of protein/protein interactions termed interactome.
Cyril eCouturier, Benoit eDeprez
doaj   +1 more source

Predicting response to platinum and non-platinum drugs through bioluminescence resonance energy transfer (BRET) based bio-molecular interactions in platinum resistant epithelial ovarian cancer

Translational Oncology, 2021
Therapy induced rewiring of signalling networks often lead to acquirement of platinum-resistance, thereby necessitating the use of non-platinum agents as second-line treatment particularly for epithelial ovarian cancer (EOC).
Aniketh Bishnu, Megha Mehrotra, Ajit Dhadve, Shalini Dimri, Abhijit De, Pritha Ray   +5 more
doaj   +1 more source

Community partner perspectives on community‐academic health research partnerships with Black American communities: A scoping review

American Journal of Community Psychology, EarlyView.
Abstract Evaluations of community‐engaged research (CEnR) typically emphasize health outcomes rather than the partnership processes that contribute to intervention effectiveness. This scoping review synthesized community partner‐identified strategies for successful community‐academic health research partnerships with Black American communities and ...
Kaylyn A. Garcia, Dylan R. Wong, Derek M. Griffith, Nada M. Goodrum, Bret Kloos, Shannon Deutsch, Guillermo M. Wippold   +6 more
wiley   +1 more source

DeepPatchNet: A deep learning model for enhanced screening and diagnosis of oral cancer

Informatics in Medicine Unlocked
Oral cancer remains a serious global health challenge, significantly affecting patient survival and quality of life. While convolutional neural networks (CNNs) have historically dominated image classification tasks, recent advances suggest that ...
Idriss Tafala, Fatima-Ezzahraa Ben-Bouazza, Aymane Edder, Oumaima Manchadi, Bassma Jioudi   +4 more
doaj   +1 more source

Leveraging multilingual RAG for breast cancer RCPs: AI-driven speech transcription and compliance in Darija-French clinical discussions

Computer Methods and Programs in Biomedicine Update
The integration of artificial intelligence (AI) into clinical decision-making has introduced new opportunities for automating and enhancing medical documentation, particularly in oncology, where multidisciplinary meetings are central to treatment ...
Ilyass Emssaad, Fatima-Ezzahraa Ben-Bouazza, Idriss Tafala, Manal Chakour El Mezali, Bassma Jioudi   +4 more
doaj   +1 more source

Ratiometric BRET Measurements of ATP with a Genetically-Encoded Luminescent Sensor

Sensors, 2019
Luciferase-based reporters provide a key measurement approach in a broad range of applications, from in vitro high-throughput screening to whole animal imaging.
Se-Hong Min, Alexander R. French, Keelan J. Trull, Kiet Tat, S. Ashley Varney, Mathew Tantama   +5 more
doaj   +1 more source

Investigation of interactions between TLR2, MyD88 and TIRAP by bioluminescence resonance energy transfer is hampered by artefacts of protein overexpression. [PDF]

PLoS ONE, 2018
Toll like receptors (TLRs) are important pattern recognition receptors that can detect pathogen and danger associated molecular patterns to initiate an innate immune response.
Natália G Sampaio, Martina Kocan, Louis Schofield, Kevin D G Pfleger, Emily M Eriksson   +4 more
doaj   +1 more source

Live-Cell Analysis of Human Cytomegalovirus DNA Polymerase Holoenzyme Assembly by Resonance Energy Transfer Methods

Microorganisms, 2021
Human cytomegalovirus (HCMV) genome replication is a complex and still not completely understood process mediated by the highly coordinated interaction of host and viral products.
Veronica Di Antonio, Giorgio Palù, Gualtiero Alvisi   +2 more
doaj   +1 more source

Transcriptomic Profiling in Skeletal Muscle Identifies Associations With Knee Osteoarthritis: The Study of Muscle, Mobility and Aging

Arthritis &Rheumatology, EarlyView.
Objective The association between skeletal muscle gene expression and knee osteoarthritis (OA) was examined among older adult participants of the Study of Muscle, Mobility and Aging (SOMMA). Methods Inclusion criteria included knee radiographs and bulk RNA sequencing in vastus lateralis muscle, resulting in 523 participants (56% female).
Daniel S. Evans, Tyler A. Mansfield, Gina M. Many, Tyler J. Sagendorf, Samaneh Farsijani, Bret H. Goodpaster, Lauren M. Sparks, Nancy E. Lane   +7 more
wiley   +1 more source

Bioluminescence Resonance Energy Transfer as a Method to Study Protein-Protein Interactions: Application to G Protein Coupled Receptor Biology

Molecules, 2019
The bioluminescence resonance energy transfer (BRET) approach involves resonance energy transfer between a light-emitting enzyme and fluorescent acceptors.
Chayma El Khamlichi, Flora Reverchon-Assadi, Nadège Hervouet-Coste, Lauren Blot, Eric Reiter, Séverine Morisset-Lopez   +5 more
doaj   +1 more source