Results 31 to 40 of about 131,173 (232)

Conformation- and activation-based BRET sensors differentially report on GPCR–G protein coupling

Science Signaling
G protein–coupled receptors (GPCRs) regulate cellular signaling processes by coupling to diverse combinations of heterotrimeric G proteins composed of Gα, Gβ, and Gγ subunits.
S. C. Wright, Charlotte Avet, Supriya A. Gaitonde, I. Muneta-Arrate, C. Le Gouill, M. Hogue, B. Breton, Stefania Koutsilieri, R. D. Alarcia, Madeleine Héroux, V. Lauschke, Michel Bouvier   +11 more
semanticscholar   +1 more source

Self Attention-Driven ECG Denoising: A Transformer-Based Approach for Robust Cardiac Signal Enhancement

Signals
The analysis of electrocardiogram (ECG) signals is profoundly affected by the presence of electromyographic (EMG) noise, which can lead to substantial misinterpretations in healthcare applications.
Aymane Edder, Fatima-Ezzahraa Ben-Bouazza, Idriss Tafala, Oumaima Manchadi, Bassma Jioudi   +4 more
doaj   +1 more source

Mathematical Models for Quantitative Assessment of Bioluminescence Resonance Energy Transfer (BRET): Application to Seven Transmembrane Receptors (7TMRs) Oligomerization

Frontiers in Endocrinology, 2012
The idea that seven transmembrane receptors (7TMRs; also designated G-protein coupled receptors (GPCRs)) might form dimers or higher order oligomeric complexes was formulated more than 20 years ago and has been intensively studied since then. In the last
Luka eDrinovec, Valentina eKubale, Jane eNøhr Larsen, Milka eVrecl   +3 more
doaj   +1 more source

Internalization dissociates β2-adrenergic receptors. [PDF]

PLoS ONE, 2011
G protein-coupled receptors (GPCRs) self-associate as dimers or higher-order oligomers in living cells. The stability of associated GPCRs has not been extensively studied, but it is generally thought that these receptors move between the plasma membrane ...
Tien-Hung Lan, Sudhakiranmayi Kuravi, Nevin A Lambert   +2 more
doaj   +1 more source

A Multimodal Deep Learning Pipeline for Enhanced Detection and Classification of Oral Cancer

Engineering Proceedings
Oral cancer represents a life-threatening malignancy with profound implications for patient survival and quality of life. Oral squamous cell carcinoma (OSCC), the predominant histological variant of oral cancer, constitutes a substantial healthcare ...
Idriss Tafala, Fatima-Ezzahraa Ben-Bouazza, Manal Chakour El Mezali, Ilyass Emssaad, Bassma Jioudi   +4 more
doaj   +1 more source

EGFR signaling and pharmacology in oncology revealed with innovative BRET-based biosensors

Communications Biology
Mutations of receptor tyrosine kinases (RTKs) are associated with the development of many cancers by modifying receptor signaling and contributing to drug resistance in clinical settings.
Florence Gross, A. Mancini, B. Breton, Hiroyuki Kobayashi, P. Pereira, C. Le Gouill, Michel Bouvier, S. Schann, Xavier Leroy, Laurent Sabbagh   +9 more
semanticscholar   +1 more source

Predictive Maintenance in Pharma Manufacturing: Challenges and Strategic Directions

Engineering Proceedings
Predictive maintenance (PdM) has emerged as a critical enabler for improving reliability, operational efficiency, and regulatory compliance in pharmaceutical manufacturing.
Oumaima Manchadi, Fatima-Ezzahraa Ben-Bouazza, Aymane Edder, Idriss Tafala, Bassma Jioudi   +4 more
doaj   +1 more source

Application of FRET- and BRET-based live-cell biosensors in deorphanization and ligand discovery studies on orphan G protein-coupled receptors.

SLAS discovery : advancing life sciences R & D
Bioluminescence- and fluorescence-based resonance energy transfer assays have gained considerable attention in pharmacological research as high-throughput scalable tools applicable to drug discovery. To this end, G protein-coupled receptors represent the
Joanna J. Sajkowska, Choi Har Tsang, P. Kozielewicz   +2 more
semanticscholar   +1 more source

Trustworthy Multimodal AI Agents for Early Breast Cancer Detection and Clinical Decision Support

Engineering Proceedings
Timely and precise identification of breast cancer is crucial for enhancing clinical outcomes; however, current AI systems frequently exhibit deficiencies in transparency, trustworthiness, and the capacity to assimilate varied data modalities.
Ilyass Emssaad, Fatima-Ezzahraa Ben-Bouazza, Idriss Tafala, Manal Chakour El Mezali, Bassma Jioudi   +4 more
doaj   +1 more source

BRET biosensor analysis of receptor tyrosine kinase functionality

Frontiers in Endocrinology, 2013
Bioluminescence resonance energy transfer (BRET) is an improved version of earlier resonance energy transfer technologies used for the analysis of biomolecular protein interaction.
Sana eSiddiqui, Wei-na eCong, Caitlin M Daimon, Bronwen eMartin, Stuart eMaudsley   +4 more
doaj   +1 more source