Results 51 to 60 of about 39,288 (183)
Clinical Pharmacology &Therapeutics, EarlyView.A mechanistic CNS PBPK model framework was applied to eight antipsychotic D2 receptor ligands, comparing brain extracellular fluid (brainECF) and brain cell membrane (brainM) as biophase for predicting human receptor occupancy compared against PET neuroimaging data. BrainM concentrations showed improved agreement with PET‐derived receptor occupancy for
Divakar Budda +2 more
wiley +1 more source
Bio-Protocol, 2019 Detecting protein-protein interactions by co-immunoprecipitation provided a major advancement in the immunology research field. In the G-protein-coupled receptors (GPCRs) research field, colocalization and co-immunoprecipitation were used to detect ...
Irene Reyes-Resina +3 more
doaj +1 more source
Epilepsia, EarlyView.Abstract This article summarizes data for 13 investigational treatments for which at least preliminary seizure outcome data in patients with epilepsy were reported at the Eighteenth Eilat Conference on New Antiepileptic Drugs and Devices held in Madrid, Spain, on May 3–6, 2026.
Meir Bialer +7 more
wiley +1 more source
Regulator of G protein signaling 2 (RGS2) and RGS4 form distinct G protein-dependent complexes with protease activated-receptor 1 (PAR1) in live cells. [PDF]
PLoS ONE, 2014 Protease-activated receptor 1 (PAR1) is a G-protein coupled receptor (GPCR) that is activated by natural proteases to regulate many physiological actions.
Sungho Ghil +2 more
doaj +1 more source
STAR Protocols, 2022 Summary: The Kinetic Intra-Cellular Assay (KICA) is a recombinant cell-based technique that utilizes NanoBRET technology. KICA enables the measurement of intracellular binding kinetics.
Charles S. Lay +5 more
doaj +1 more source
The Journal of Wildlife Management, EarlyView.Deer Management Assistance Program hunter satisfaction in Pennsylvania increased over time and was associated with antlerless deer harvest success, repeated permit purchases, and seeing an antlerless deer. Understanding these relationships can help wildlife agencies support both deer management objectives and long‐term hunter engagement.
Arun Regmi +11 more
wiley +1 more source
Coleccion de sermones de D. Bruno Bret ... [PDF]
T. III: Sermones de Cuaresma I, 271 p. -- T. IV: Sermones de Cuaresma II, 270 p. -- T. V: Sermones para ejercicios espirituales, [6], 255, [1] p. -- T. VI: Sermones del Smo. Sacramento, [6], 287, [1] p. -- T.
Bret, Bruno, 1771-1844
core +1 more source
Competition and soil conditions limit the growth of High Arctic non‐native plants
Oikos, EarlyView.Non‐native vascular plant species in the High Arctic are currently restricted mainly to settlements and other anthropogenically disturbed areas. The reasons for this remain unclear, but climate or dispersal do not appear to be the main limiting factors. Instead, biotic interactions combined with soil conditions may play important roles.
Jana Ruethers +6 more
wiley +1 more source
PM&R, EarlyView.Abstract Background Platelet‐rich plasma injections (PRPI) are a relatively new and evolving treatment option for a variety of musculoskeletal injuries. It has been theorized that there is an increased risk of septic arthritis (SA) with PRPI, though there have been no dedicated studies to assess the incidence of SA and only three cases have been ...
Kory Ford +4 more
wiley +1 more source
Image Processing for Bioluminescence Resonance Energy Transfer Measurement—BRET-Analyzer
Frontiers in Computational Neuroscience, 2018 A growing number of tools now allow live recordings of various signaling pathways and protein-protein interaction dynamics in time and space by ratiometric measurements, such as Bioluminescence Resonance Energy Transfer (BRET) Imaging.
Yan Chastagnier +11 more
doaj +1 more source