Results 11 to 20 of about 92,366 (134)

Temporal characteristics of astrocytic activation in the TNC in a mice model of pain induced by recurrent dural infusion of inflammatory soup

The Journal of Headache and Pain, 2022
Background Astrocytic activation might play a significant role in the central sensitization of chronic migraine (CM). However, the temporal characteristics of the astrocytic activation in the trigeminal nucleus caudalis (TNC) and the molecular mechanism ...
Leyi Zhang, Chenglong Lu, Li Kang, Yingji Li, Wenjing Tang, Dengfa Zhao, Shengyuan Yu, Ruozhuo Liu   +7 more
doaj   +1 more source

A new clinical prognostic nomogram for liver cancer based on immune score.

PLoS ONE, 2020
BackgroundIncreased attention is being paid to the relationship between the immune status of the tumor microenvironment and tumor prognosis. The application of immune scoring in evaluating the clinical prognosis of liver cancer patients has not yet been ...
Qinyan Shen, Guinv Hu, JinZhong Wu, Liting Lv   +3 more
doaj   +1 more source

The Role of the CXCL12/CXCR4/CXCR7 Chemokine Axis in Cancer

Frontiers in Pharmacology, 2020
Chemokines are a family of small, secreted cytokines which regulate a variety of cell functions. The C-X-C motif chemokine ligand 12 (CXCL12) binds to C-X-C chemokine receptor type 4 (CXCR4) and C-X-C chemokine receptor type 7 (CXCR7). The interaction of
Yi Shi, David J. Riese, Jianzhong Shen
doaj   +1 more source

α1‐Adrenergic Receptors Function Within Hetero‐Oligomeric Complexes With Atypical Chemokine Receptor 3 and Chemokine (C‐X‐C motif) Receptor 4 in Vascular Smooth Muscle Cells

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2017
BackgroundRecently, we provided evidence that α1‐adrenergic receptors (ARs) in vascular smooth muscle are regulated by chemokine (C‐X‐C motif) receptor (CXCR) 4 and atypical chemokine receptor 3 (ACKR3). While we showed that CXCR4 controls α1‐ARs through
Lauren J. Albee, Jonathan M. Eby, Abhishek Tripathi, Heather M. LaPorte, Xianlong Gao, Brian F. Volkman, Vadim Gaponenko, Matthias Majetschak   +7 more
doaj   +1 more source

CXCL12/CXCR4 axis: an emerging neuromodulator in pathological pain [PDF]

, 2016
The roles of chemokine C-X-C motif ligand 12 (CXCL12) and its receptor chemokine C-X-C motif receptor 4 (CXCR4) reveal this chemokine axis as an emerging neuromodulator in the nervous system. In the peripheral and central nervous systems, both CXCL12 and
Cheung, CW, Chung, SK, Luo, X, Wang, XMA, Xia, Z   +4 more
core   +1 more source

Gene Expression Profiling of Peripheral Blood Mononuclear Cells in Type 2 Diabetes: An Exploratory Study

Medicina, 2022
Background and Objectives: Visceral obesity is associated with chronic low-grade inflammation that predisposes to metabolic syndrome. Indeed, infiltration of adipose tissue with immune–inflammatory cells, including ‘classical’ inflammatory M1 and anti ...
Hana M. A. Fakhoury, Muhammad Affan Elahi, Saud Al Sarheed, Mohammed Al Dubayee, Awad Alshahrani, Mahmoud Zhra, Arwa Almassri, Ahmad Aljada   +7 more
doaj   +1 more source

Targeting CXCL12 from FAP-expressing carcinoma-associated fibroblasts synergizes with anti-PD-L1 immunotherapy in pancreatic cancer [PDF]

, 2013
An autochthonous model of pancreatic ductal adenocarcinoma (PDA) permitted the analysis of why immunotherapy is ineffective in this human disease. Despite finding that PDA-bearing mice had cancer cell-specific CD8+ T cells, the mice, like human patients ...
Caballero, O. L., Chan, D. S., Connell, C. M., Deonarine, A., Fearon, D. T., Feig, C., Janowitz, T., Jodrell, D. I., Jones, J. O., Kraman, M., Roberts, E. W., Teichmann, S. A., Tuveson, D. A., Wells, R. J. B., Zhao, Q.   +14 more
core   +1 more source

The clinical usefulness of chemokine C-X-C Motif Ligand 12 as a diagnostic marker for Papillary Thyroid Carcinoma

Indian Journal of Pathology and Microbiology, 2020
Background: Papillary thyroid carcinoma (PTC) is the most common type of thyroid cancer worldwide. It is essential to develop methods for the accurate diagnosis of PTC to avoid unnecessary surgery.
Sang Ah Lee, Jae Hyuck Choi, Suk Ju Cho, Jee Won Chang, Young Hee Maeng   +4 more
doaj   +1 more source

Redox-Active Protein Thioredoxin-1 Administration Ameliorates Influenza A Virus (H1N1)-Induced Acute Lung Injury in Mice [PDF]

, 2013
Objectives: Influenza virus infections can cause severe acute lung injury leading to significant morbidity and mortality. Thioredoxin-1 is a redox-active defensive protein induced in response to stress conditions.
Abdel-Ghafar, Akaike, Akaike, Atkuri, Beck, Beckman, Callister, Callister, Cho, Choi, Fleming, Garozzo, Ghezzi, Hagau, Hashiba, Hofer, Hoshino, Ichiki, Ito, Kaimul Ahsan, Kasuno, Kato, Leaver, Matsui, Matsukawa, Mitsui, Nakamura, Nakamura, Nakamura, Ohashi, Ohta, Pasquini, Sato, Sato, Shi, Shioji, Suliman, Takagi, Tao, Todoroki, Tomofuji, Toyokuni, Toyokuni, Tsukahara, Uchide, Ueda, Xu, Yamada   +47 more
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The biological role of the CXCL12/CXCR4 axis in esophageal squamous cell carcinoma

Cancer Biology & Medicine, 2021
Esophageal cancer is the eighth most common malignant tumor and the sixth leading cause of cancer-related death worldwide. Esophageal squamous cell carcinoma (ESCC) is the main histological type of esophageal cancer, and accounts for 90% of all cancer ...
Xianxian Wu, Hongdian Zhang, Zhilin Sui, Yang Wang, Zhentao Yu   +4 more
doaj   +1 more source