Results 81 to 90 of about 111,292 (192)

Cytokine-armed oncolytic herpes simplex viruses: a game-changer in cancer immunotherapy?

Journal for ImmunoTherapy of Cancer
Cytokines are small proteins that regulate the growth and functional activity of immune cells, and several have been approved for cancer therapy. Oncolytic viruses are agents that mediate antitumor activity by directly killing tumor cells and inducing ...
Howard L Kaufman, Hongbin Wang, Dipongkor Saha, Samuel D Rabkin, Mia Borlongan, Uyen Le, Hans J Nauwynck   +6 more
doaj   +1 more source

Transcriptomic analysis identifies CXCL12 as a novel candidate gene for litter size in rabbits [PDF]

Animal Bioscience
Objective The ovary, as an important reproductive organ, tightly regulates the litter size of rabbits through its complex network of genes. This study aims to identify candidate genes related to litter size in rabbits through RNA sequencing and to ...
Zhiyuan Bao, Jie Yang, Jiali Li, Jiawei Cai, Pin Zhai, Pinyi Zhao, Bohao Zhao, Yang Chen, Xinsheng Wu   +8 more
doaj   +1 more source

Stronger inflammatory/cytotoxic T cell response in women identified by microarray analysis [PDF]

, 2008
Women develop chronic inflammatory autoimmune diseases like lupus more often than men. The mechanisms causing the increased susceptibility are incompletely understood, although estrogen is believed to contribute.
Anura Hewagama, Bruce C. Richardson, Dipak Patel, Faith M. Strickland, Sushma Yarlagadda   +4 more
core   +1 more source

Chemokine-mediated inflammation in the degenerating retina is coordinated by Müller cells, activated microglia, and retinal pigment epithelium [PDF]

, 2015
BACKGROUND Monocyte infiltration is involved in the pathogenesis of many retinal degenerative conditions. This process traditionally depends on local expression of chemokines, though the roles of many of these in the degenerating retina are unclear. Here,
Chia, RX, Natoli, Riccardo, Provis, Jan M, Rutar, Matt, Valter, Krisztina   +4 more
core   +2 more sources

Effects of ricin on primary pulmonary alveolar macrophages

Journal of International Medical Research, 2019
Objective We systematically investigated the cytotoxic effects of ricin in primary pulmonary alveolar macrophages (PAMs). Methods Primary PAMs were isolated from BALB/c mice.
Zhendong Guo, Zhongyi Wang, Shanyu Meng, Zongzheng Zhao, Chunmao Zhang, Yingying Fu, Jiaming Li, Xin Nie, Cheng Zhang, Linna Liu, Bing Lu, Jun Qian   +11 more
doaj   +1 more source

The atypical chemokine receptor Ackr2 constrains NK cell migratory activity and promotes metastasis [PDF]

, 2018
Chemokines have been shown to be essential players in a range of cancer contexts. In this study, we demonstrate that mice deficient in the atypical chemokine receptor Ackr2 display impaired development of metastasis in vivo in both cell line and ...
Brownlie, Demi, Burgoyne, Paul, Burt, Claire L., Fraser, Alasdair R., Graham, Gerard J., Hansell, Christopher A.H., Hayes, Alan J., Lee, Kit Ming, Macleod, Megan K.L., Medina-Ruiz, Laura, Nibbs, Robert J.B., Pingen, Marieke, Wilson, Gillian J.   +12 more
core   +1 more source

Data from Chemokine (C-X-C Motif) Ligand 12 Is Associated with Gallbladder Carcinoma Progression and Is a Novel Independent Poor Prognostic Factor

, 2023
<div>Abstract<p><b>Purpose:</b> Although recent studies have suggested that chemokine (C-X-C motif) ligand 12 (CXCL12) is important in the progression of various malignancies, its role in gallbladder carcinoma (GBC) remains unknown.
Hyo Jin Lee, Jin-Man Kim, Jeong-Ki Min, Deog Yeon Jo, Ha Yon Kim, Yoon Suk Oh, Song Mei Huang, Zhe Long Liang, Jang-Seong Kim, Kwang-Hee Bae, Dong Gwang Lee, Kyungmin Lee, Hyun Jung Lee   +12 more
openaire   +1 more source

Targeting the CXCR4 pathway using a novel anti-CXCR4 IgG1 antibody (PF-06747143) in chronic lymphocytic leukemia. [PDF]

, 2017
BackgroundThe CXCR4-CXCL12 axis plays an important role in the chronic lymphocytic leukemia (CLL)-microenvironment interaction. Overexpression of CXCR4 has been reported in different hematological malignancies including CLL.
Amaya-Chanaga, Carlos I, Amine, Ale-Ali, Castro, Januario E, Choi, Michael Y, Fantin, Valeria R, Gu, Yin, Hallin, Max, Huser, Nanni, Kashyap, Manoj K, Kipps, Thomas J, Kumar, Deepak, Lindquist, Kevin, Liu, Shu-Hui, Pernasetti, Flavia, Rassenti, Laura Z, Simmons, Brett, Smeal, Tod, Yafawi, Rolla, Zhang, Cathy   +18 more
core   +4 more sources

C-X-C Motif Chemokine Receptor 4 Blockade Promotes Tissue Repair After Myocardial Infarction by Enhancing Regulatory T Cell Mobilization and Immune-Regulatory Function

Circulation, 2019
Background: Acute myocardial infarction (MI) elicits an inflammatory response that drives tissue repair and adverse cardiac remodeling. Inflammatory cell trafficking after MI is controlled by C-X-C motif chemokine ligand 12 (CXCL12) and its receptor, C-X-
Yong Wang, K. Dembowsky, É. Chevalier, Philipp Stüve, M. Korf-Klingebiel, M. Lochner, L. Napp, H. Frank, E. Brinkmann, Anna Kanwischer, J. Bauersachs, M. Gyöngyösi, T. Sparwasser, K. Wollert   +13 more
semanticscholar   +1 more source

Supplementary Table 1 from Chemokine (C-X-C Motif) Ligand 12 Is Associated with Gallbladder Carcinoma Progression and Is a Novel Independent Poor Prognostic Factor

, 2023
<p>PDF file - 45K, Relationship of CXCR4 expression and clinicopathological characteristics of gallbladder carcinoma</p>
Hyo Jin Lee, Jin-Man Kim, Jeong-Ki Min, Deog Yeon Jo, Ha Yon Kim, Yoon Suk Oh, Song Mei Huang, Zhe Long Liang, Jang-Seong Kim, Kwang-Hee Bae, Dong Gwang Lee, Kyungmin Lee, Hyun Jung Lee   +12 more
openaire   +1 more source