Results 1 to 10 of about 325,163 (330)

Time-lapse imaging of <i>C. elegans</i> egg-laying with high spatiotemporal resolution. [PDF]

MicroPubl Biol
Balachandar Thendral S, Roos N, Vertiz J, S Wokasch A, Maier P, R Sherwood D.   +5 more
europepmc   +3 more sources

BAP1 Malignant Pleural Mesothelioma Mutations in Caenorhabditis elegans Reveal Synthetic Lethality between ubh-4/BAP1 and the Proteasome Subunit rpn-9/PSMD13

Cells, 2023
The deubiquitinase BAP1 (BRCA1-associated protein 1) is associated with BAP1 tumor predisposition syndrome (TPDS). BAP1 is a tumor suppressor gene whose alterations in cancer are commonly caused by gene mutations leading to protein loss of function.
Carmen Martínez-Fernández, Sweta Jha, Elisabet Aliagas, Carina I. Holmberg, Ernest Nadal, Julián Cerón   +5 more
doaj   +1 more source

Insights into cisplatin-induced neurotoxicity and mitochondrial dysfunction in Caenorhabditis elegans

Disease Models & Mechanisms, 2022
Cisplatin is the most common drug in first-line chemotherapy against solid tumors. We and others have previously used the nematode Caenorhabditis elegans to identify genetic factors influencing the sensitivity and resistance to cisplatin.
Carmen Martínez-Fernández, Milana Bergamino, Alfonso Schiavi, David Brena, Natascia Ventura, Sebastian Honnen, Alberto Villanueva, Ernest Nadal, Julián Cerón   +8 more
doaj   +1 more source

The Caenorhabditis elegans cuticle plays an important role against toxicity to bisphenol A and bisphenol S

Toxicology Reports, 2023
Caenorhabditis elegans represents a favorite non-mammalian animal model, which is often used to study the effect of foreign substances on living organisms. Its epidermal barrier is a primary biological barrier that protects nematodes from the toxicity of
Soňa Kucharíková, Patrícia Hockicková, Kamila Melnikov, Zuzana Bárdyová, Alžbeta Kaiglová   +4 more
doaj   +1 more source

Genome editing in animals with minimal PAM CRISPR-Cas9 enzymes

Nature Communications, 2022
PAM requirement is a constraint for genome editing but this has been circumvented by engineered Cas9 nucleases as SpG and SpRY recognizing minimal PAM sequences.
Jeremy Vicencio, Carlos Sánchez-Bolaños, Ismael Moreno-Sánchez, David Brena, Charles E. Vejnar, Dmytro Kukhtar, Miguel Ruiz-López, Mariona Cots-Ponjoan, Alejandro Rubio, Natalia Rodrigo Melero, Jesús Crespo-Cuadrado, Carlo Carolis, Antonio J. Pérez-Pulido, Antonio J. Giráldez, Benjamin P. Kleinstiver, Julián Cerón, Miguel A. Moreno-Mateos   +16 more
doaj   +1 more source

AKIR-1 regulates proteasome subcellular function in Caenorhabditis elegans

iScience, 2023
Summary: Polyubiquitinated proteins are primarily degraded by the ubiquitin-proteasome system (UPS). Proteasomes are present both in the cytoplasm and nucleus. Here, we investigated mechanisms coordinating proteasome subcellular localization and activity
Johanna Pispa, Elisa Mikkonen, Leena Arpalahti, Congyu Jin, Carmen Martínez-Fernández, Julián Cerón, Carina I. Holmberg   +6 more
doaj   +1 more source

Metabolic and behavioral effects of olanzapine and fluoxetine on the model organism Caenorhabditis elegans

Saudi Pharmaceutical Journal, 2021
The use of many psychotropic drugs (PDs) is associated with increased caloric intake, significant weight gain, and metabolic disorders. The nematode Caenorhabditis elegans (C. elegans) has been used to study the effects of PDs on food intake.
Abdullah Almotayri, Jency Thomas, Mihiri Munasinghe, Maneka Weerasinghe, Deniz Heydarian, Markandeya Jois   +5 more
doaj   +1 more source

The nematode worm Caenorhabditis elegans as an animal experiment replacement for assessing the virulence of different Salmonella enterica strains

Frontiers in Microbiology, 2023
Caenorhabditis (C.) elegans has become a popular toxicological and biological test organism in the last two decades. Furthermore, the role of C. elegans as an alternative for replacing or reducing animal experiments is continuously discussed and ...
Wiebke Burkhardt, Carina Salzinger, Jennie Fischer, Burkhard Malorny, Matthias Fischer, Istvan Szabo   +5 more
doaj   +1 more source

Probiotic Lacticaseibacillus rhamnosus GG Increased Longevity and Resistance Against Foodborne Pathogens in Caenorhabditis elegans by Regulating MicroRNA miR-34

Frontiers in Cellular and Infection Microbiology, 2022
In this study, we investigated the relation of probiotic activity of Lacticaseibacillus rhamnosus strain GG (LGG) and expression of microRNA to immune response and longevity in Caenorhabditis elegans host model. First, we evaluated the survival rate of C.
Bohyun Yun, Sangdon Ryu, Minkyoung Kang, Juyeon Lee, Jiseon Yoo, Younghoon Kim, Sangnam Oh   +6 more
doaj   +1 more source

Caenorhabditis Elegans Exhibits Morphine Addiction-like Behavior via the Opioid-like Receptor NPR-17

Frontiers in Pharmacology, 2022
Addiction has become a profound societal problem worldwide, and few effective treatments are available. The nematode Caenorhabditis elegans (C. elegans) is an excellent invertebrate model to study neurobiological disease states. C.
Soichiro Ide, Hirofumi Kunitomo, Yuichi Iino, Kazutaka Ikeda   +3 more
doaj   +1 more source