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Transcriptional factor PU.1 regulates decidual C1q expression in early pregnancy in human [PDF]
Frontiers in Immunology, 2015 C1q is the first recognition subcomponent of the complement classical pathway, which in addition to being synthesized in the liver, is also expressed by macrophages and dendritic cells.
Priyaa Madhukaran Raj +5 more
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Ultrastructure of Human C1q Protein [PDF]
Nature New Biology, 1972 THE first component (C1) in the complement system may be defined functionally as a macromolecule capable of binding to antigen-antibody complexes and inducing the sequential reactions of this system. C1 consists of three distinct proteins named C1q, C1r and C1s which,in serum, form a macromolecular complex held together by calcium ions1.
Sven‐Eric Svehag, L. MANHEM, B. Bloth
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Frontiers in Neuroscience, 2021 ObjectiveComplement activation is instrumental in the pathogenesis of Hypoxic-ischemic encephalopathy (HIE), a significant cause of neonatal mortality and disability worldwide.
Tushar A. Shah +9 more
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The role of complement component C1q in angiogenesis
Exploration of Immunology, 2023 The complement component C1q plays a role as a pro-angiogenic factor in different contexts, acting in a complement-independent way. For example, this molecule is able to foster the remodeling of the spiral arteries for a physiological pregnancy and to ...
Mariagiulia Spazzapan +3 more
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eLife, 2020 The ability of a well-known component of the complement cascade to bind to a variety of receptors has implications for signaling biology, spinal cord injury and, possibly, the evolution of the complement system.
Mark Noble, Christoph Pröschel
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Complement Component C1q as an Emerging Biomarker for the Diagnosis of Tuberculous Pleural Effusion
Frontiers in Microbiology, 2021 Background and Objective: The accurate differential diagnosis of tuberculous pleural effusion (TPE) from other exudative pleural effusions is often challenging.
Xin Qiao +3 more
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Change in C1q deposition in C1q nephropathy [PDF]
Pediatric Nephrology, 2009 Sirs, We read with interest the article entitled “A single-center study of C1q nephropathy in children” by Roberti et al. in the latest issue of this journal [1]. They reviewed the records of 14 children with C1q nephropathy (C1qN) and found a high incidence in pediatric patients (14/264, 5.3%), with variable clinical presentation.
Ken Hatae +4 more
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Clinical & Translational Immunology, 2022 Objectives Systemic lupus erythematosus (SLE) is a clinically heterogeneous autoimmune disease with complex pathogenic mechanisms. Complement C1q has been shown to play a major role in SLE, and autoantibodies against C1q (anti‐C1q) are strongly ...
Pascal Alexander Rabatscher +1 more
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A non-redundant role of complement protein C1q in normal and adverse pregnancy
Exploration of Immunology, 2022 Complement component 1q (C1q) is the recognition molecule of the classical pathway of the complement system that can bind to an array of closely spaced antigen-bound immunoglobulin G (IgG) and IgM antibodies.
Chiara Agostinis +4 more
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