Results 1 to 10 of about 57,775 (215)

C1q Is Recognized as a Soluble Autoantigen by Anti-C1q Antibodies of Patients with Systemic Lupus Erythematosus [PDF]

Antibodies
Background and Aims: C1q is an autoantigen in different autoimmune disorders, Systemic Lupus Erythematosus (SLE) and Lupus Nephritis (LN) among them. The two functional domains of C1q, the collagen-like region (CLR) and the globular head region (gC1q ...
Alexandra Anatolieva Atanasova, Ginka Ilieva Cholakova, Alexandra Panagiotis Kapogianni, Vancho Donev, Delina Ivanova, Anna Dimitrova Yordanova, Vanya Petkova Bogoeva, Ivanka Georgieva Tsacheva   +7 more
doaj   +2 more sources

The role of complement component C1q in angiogenesis

Exploration of Immunology, 2023
The complement component C1q plays a role as a pro-angiogenic factor in different contexts, acting in a complement-independent way. For example, this molecule is able to foster the remodeling of the spiral arteries for a physiological pregnancy and to ...
Mariagiulia Spazzapan, Silvia Pegoraro, Chiara Agostinis, Roberta Bulla   +3 more
doaj   +1 more source

Therapeutic Hypothermia Inhibits the Classical Complement Pathway in a Rat Model of Neonatal Hypoxic-Ischemic Encephalopathy

Frontiers in Neuroscience, 2021
ObjectiveComplement activation is instrumental in the pathogenesis of Hypoxic-ischemic encephalopathy (HIE), a significant cause of neonatal mortality and disability worldwide.
Tushar A. Shah, Tushar A. Shah, Tushar A. Shah, Tushar A. Shah, Haree K. Pallera, Cortney L. Kaszowski, William Thomas Bass, William Thomas Bass, William Thomas Bass, Frank A. Lattanzio   +9 more
doaj   +1 more source

Complement Component C1q as an Emerging Biomarker for the Diagnosis of Tuberculous Pleural Effusion

Frontiers in Microbiology, 2021
Background and Objective: The accurate differential diagnosis of tuberculous pleural effusion (TPE) from other exudative pleural effusions is often challenging.
Xin Qiao, Ming-Ming Shao, Feng-Shuang Yi, Huan-Zhong Shi   +3 more
doaj   +1 more source

Anti‐C1q autoantibodies from systemic lupus erythematosus patients enhance CD40–CD154‐mediated inflammation in peripheral blood mononuclear cells in vitro

Clinical & Translational Immunology, 2022
Objectives Systemic lupus erythematosus (SLE) is a clinically heterogeneous autoimmune disease with complex pathogenic mechanisms. Complement C1q has been shown to play a major role in SLE, and autoantibodies against C1q (anti‐C1q) are strongly ...
Pascal Alexander Rabatscher, Marten Trendelenburg   +1 more
doaj   +1 more source

Change in C1q deposition in C1q nephropathy [PDF]

Pediatric Nephrology, 2009
Sirs, We read with interest the article entitled “A single-center study of C1q nephropathy in children” by Roberti et al. in the latest issue of this journal [1]. They reviewed the records of 14 children with C1q nephropathy (C1qN) and found a high incidence in pediatric patients (14/264, 5.3%), with variable clinical presentation.
Kazunari, Kaneko, Masafumi, Hasui, Ken, Hatae, Hidenori, So, Ritsuko, Katafuchi   +4 more
openaire   +2 more sources

A non-redundant role of complement protein C1q in normal and adverse pregnancy

Exploration of Immunology, 2022
Complement component 1q (C1q) is the recognition molecule of the classical pathway of the complement system that can bind to an array of closely spaced antigen-bound immunoglobulin G (IgG) and IgM antibodies.
Chiara Agostinis, Alessandro Mangogna, Andrea Balduit, Uday Kishore, Roberta Bulla   +4 more
doaj   +1 more source

Complement, C1q, and C1q-Related Molecules Regulate Macrophage Polarization [PDF]

Frontiers in Immunology, 2014
Complement is a critical system of enzymes, regulatory proteins, and receptors that regulates both innate and adaptive immune responses. Natural mutations in complement molecules highlight their requirement in regulation of a variety of human conditions including infectious disease and autoimmunity.
Bohlson, Suzanne S., O’Conner, Sean D., Hulsebus, Holly Jo, Ho, Minh-Minh, Fraser, Deborah A.   +4 more
openaire   +3 more sources

C1q A08 Is a Half-Cryptic Epitope of Anti-C1q A08 Antibodies in Lupus Nephritis and Important for the Activation of Complement Classical Pathway

Frontiers in Immunology, 2020
To investigate the fine epitope(s) of anti-C1q A08 antibodies and their roles in complement activation in lupus nephritis, C1q A08 and related peptides with various amino acid sequences around A08 were synthesized.
Wen-Jun Wu, Wen-Jun Wu, Wen-Jun Wu, Wen-Jun Wu, Wen-Jun Wu, Wen-Jun Wu, Ying Tan, Ying Tan, Ying Tan, Ying Tan, Xiao-Ling Liu, Xiao-Ling Liu, Xiao-Ling Liu, Xiao-Ling Liu, Feng Yu, Feng Yu, Feng Yu, Feng Yu, Feng Yu, Ming-Hui Zhao, Ming-Hui Zhao, Ming-Hui Zhao, Ming-Hui Zhao, Ming-Hui Zhao   +23 more
doaj   +1 more source

Peptide inhibitor of complement C1 (PIC1), a novel suppressor of classical pathway activation: mechanistic studies and clinical potential

Frontiers in Immunology, 2014
The classical pathway of complement plays multiple physiological roles including modulating immunological effectors initiated by adaptive immune responses as well as an essential homeostatic role in the clearance of damaged self-antigens.
Julia A Sharp, Pamela H. Whitley, Kenji M. Cunnion, Kenji M. Cunnion, Neel Kumar Krishna, Neel Kumar Krishna   +5 more
doaj   +1 more source