Results 1 to 10 of about 62,354 (276)

Transcriptional factor PU.1 regulates decidual C1q expression in early pregnancy in human [PDF]

Frontiers in Immunology, 2015
C1q is the first recognition subcomponent of the complement classical pathway, which in addition to being synthesized in the liver, is also expressed by macrophages and dendritic cells.
Priyaa Madhukaran Raj, Uday eKishore, Kaiser eJamil, Boon eTeo, Mahesh eChoolani, Jinhua eLu   +5 more
doaj   +4 more sources

C1q Is Recognized as a Soluble Autoantigen by Anti-C1q Antibodies of Patients with Systemic Lupus Erythematosus [PDF]

Antibodies
Background and Aims: C1q is an autoantigen in different autoimmune disorders, Systemic Lupus Erythematosus (SLE) and Lupus Nephritis (LN) among them. The two functional domains of C1q, the collagen-like region (CLR) and the globular head region (gC1q ...
Alexandra Anatolieva Atanasova, Ginka Ilieva Cholakova, Alexandra Panagiotis Kapogianni, Vancho Donev, Delina Ivanova, Anna Dimitrova Yordanova, Vanya Petkova Bogoeva, Ivanka Georgieva Tsacheva   +7 more
doaj   +2 more sources

Microglial Extracellular Vesicles Mediate C1q Deposition at the Pre-Synapse and Promote Synaptic Pruning. [PDF]

J Extracell Vesicles
D'Arrigo G, Cutugno G, Golia MT, Sironi F, Lombardi M, Colombo SF, Frigerio R, Cretich M, Gagni P, Battocchio E, Barone C, Azzoni E, Bellini S, Saraceno C, Ghidoni R, Bendotti C, Paolicelli RC, Gabrielli M, Verderio C.   +18 more
europepmc   +3 more sources

Investigating the Effects of C1q‐Blocking Using a CDC‐Mutant 3D6 Antibody on ARIA in 5XE4 Mice [PDF]

Alzheimers Dement
Colletti B, Bathini P, Navani I, Holtzman D, Saadi F, Schilling S, Rahfeld J, Lemere C.   +7 more
europepmc   +3 more sources

The role of complement component C1q in angiogenesis

Exploration of Immunology, 2023
The complement component C1q plays a role as a pro-angiogenic factor in different contexts, acting in a complement-independent way. For example, this molecule is able to foster the remodeling of the spiral arteries for a physiological pregnancy and to ...
Mariagiulia Spazzapan, Silvia Pegoraro, Chiara Agostinis, Roberta Bulla   +3 more
doaj   +1 more source

Therapeutic Hypothermia Inhibits the Classical Complement Pathway in a Rat Model of Neonatal Hypoxic-Ischemic Encephalopathy

Frontiers in Neuroscience, 2021
ObjectiveComplement activation is instrumental in the pathogenesis of Hypoxic-ischemic encephalopathy (HIE), a significant cause of neonatal mortality and disability worldwide.
Tushar A. Shah, Tushar A. Shah, Tushar A. Shah, Tushar A. Shah, Haree K. Pallera, Cortney L. Kaszowski, William Thomas Bass, William Thomas Bass, William Thomas Bass, Frank A. Lattanzio   +9 more
doaj   +1 more source

Anti‐C1q autoantibodies from systemic lupus erythematosus patients enhance CD40–CD154‐mediated inflammation in peripheral blood mononuclear cells in vitro

Clinical & Translational Immunology, 2022
Objectives Systemic lupus erythematosus (SLE) is a clinically heterogeneous autoimmune disease with complex pathogenic mechanisms. Complement C1q has been shown to play a major role in SLE, and autoantibodies against C1q (anti‐C1q) are strongly ...
Pascal Alexander Rabatscher, Marten Trendelenburg   +1 more
doaj   +1 more source

Complement Component C1q as an Emerging Biomarker for the Diagnosis of Tuberculous Pleural Effusion

Frontiers in Microbiology, 2021
Background and Objective: The accurate differential diagnosis of tuberculous pleural effusion (TPE) from other exudative pleural effusions is often challenging.
Xin Qiao, Ming-Ming Shao, Feng-Shuang Yi, Huan-Zhong Shi   +3 more
doaj   +1 more source

Change in C1q deposition in C1q nephropathy [PDF]

Pediatric Nephrology, 2009
Sirs, We read with interest the article entitled “A single-center study of C1q nephropathy in children” by Roberti et al. in the latest issue of this journal [1]. They reviewed the records of 14 children with C1q nephropathy (C1qN) and found a high incidence in pediatric patients (14/264, 5.3%), with variable clinical presentation.
Kazunari, Kaneko, Masafumi, Hasui, Ken, Hatae, Hidenori, So, Ritsuko, Katafuchi   +4 more
openaire   +2 more sources

The Humoral Theory of Transplantation: Epitope Analysis and the Pathogenicity of HLA Antibodies. [PDF]

, 2016
Central to the humoral theory of transplantation is production of antibodies by the recipient against mismatched HLA antigens in the donor organ. Not all mismatches result in antibody production, however, and not all antibodies are pathogenic.
Farber, John, Filippone, Edward J
core   +8 more sources