Results 1 to 10 of about 68,566 (325)
Transcriptional factor PU.1 regulates decidual C1q expression in early pregnancy in human [PDF]
Frontiers in Immunology, 2015 C1q is the first recognition subcomponent of the complement classical pathway, which in addition to being synthesized in the liver, is also expressed by macrophages and dendritic cells.
Priyaa Madhukaran Raj +5 more
doaj +7 more sources
C1q and central nervous system disorders
Frontiers in Immunology, 2023 C1q is a crucial component of the complement system, which is activated through the classical pathway to perform non-specific immune functions, serving as the first line of defense against pathogens.
Wenjie Zhang +3 more
doaj +2 more sources
C1q acts in the tumour microenvironment as a cancer-promoting factor independently of complement activation [PDF]
Nature Communications, 2016 Complement C1q is the activator of the classical pathway. However, it is now recognized that C1q can exert functions unrelated to complement activation.
R. Bulla +9 more
semanticscholar +4 more sources
The collagen structure of C1q induces wound healing by engaging discoidin domain receptor 2
Molecular Medicine, 2021 Background C1q has been reported to reveal complement-independent roles in immune and non-immune cells. C1q binds to its specific receptors to regulate distinct functions that rely on the environment and cell types.
Ria Aryani Hayuningtyas +9 more
doaj +2 more sources
Autoantibodies against complement component C1q in systemic lupus erythematosus
Clinical & Translational Immunology, 2021 Systemic lupus erythematosus (SLE) is the archetype of a systemic autoimmune disease, but the multifaceted pathogenic mechanisms leading to inflammation and organ damage are not fully understood.
Marten Trendelenburg
doaj +2 more sources
Scientific Reports, 2021 It was reported that histopathologic lesions are risk factors for the progression of IgA Nephropathy (IgAN). The aim of this study was to investigate the relationships between mesangial deposition of C1q and renal outcomes in IgAN.
Li Tan +8 more
doaj +2 more sources
Ultrastructure of Human C1q Protein [PDF]
Nature New Biology, 1972 THE first component (C1) in the complement system may be defined functionally as a macromolecule capable of binding to antigen-antibody complexes and inducing the sequential reactions of this system. C1 consists of three distinct proteins named C1q, C1r and C1s which,in serum, form a macromolecular complex held together by calcium ions1.
Sven‐Eric Svehag, L. MANHEM, B. Bloth
openalex +4 more sources
Journal of Neuroinflammation, 2020 Background Cognitive impairment in schizophrenia, aging, and Alzheimer’s disease is associated with spine and synapse loss from the dorsolateral prefrontal cortex (dlPFC) layer III.
Dibyadeep Datta +7 more
doaj +2 more sources
Frontiers in Immunology, 2017 Binding of the complement component C1q to the CH2 domain of antigen-bound immunoglobulin gamma (IgG) activates the classical complement pathway and depends on its close proximity to Fc fragments of neighboring antibodies. IgG subclasses contain a highly
Benjamin Peschke +6 more
doaj +2 more sources
Frontiers in Immunology, 2019 Previous infection with Epstein-Barr virus (EBV) is believed to trigger autoimmunity and to drive autoantibody generation as occurring in patients with systemic lupus erythematosus (SLE). Complement C1q and autoantibodies targeting it (anti-C1q) are also
Kinga Csorba +8 more
doaj +2 more sources