Results 171 to 180 of about 70,452 (309)

Building Immunocompetent Cerebral Organoids From a Developmental Perspective

Glia, Volume 73, Issue 11, Page 2154-2166, November 2025.
Main Points Conventional cerebral organoids do not contain microglia, which must be added. We propose recommendations to assess microglial immunocompetence using quantitative approaches and stringent statistical analysis to help develop standardized protocols.
Xabier Cuesta‐Puente, Marco Gonzalez‐Dominguez, Marta Pereira‐Iglesias, Nerea Perez‐Arriazu, Patricia Villegas‐Zafra, Paula Ramos‐Gonzalez, Fabio Cavaliere, Nora Bengoa‐Vergniory, Amanda Sierra   +8 more
wiley   +1 more source

Lack of activation of C1, despite circulating immune complexes detected by two C1q methods, in patients with rheumatoid arthritis [PDF]

, 1984
C. Erik Hack, A J Eerenberg-Belmer, Uwi G. Lim, J F Haverman, Rob C. Aalberse   +4 more
openalex   +1 more source

Cancer‐Associated Fibroblasts: Origin, Classification, Tumorigenicity, and Targeting for Cancer Therapy

MedComm, Volume 6, Issue 11, November 2025.
This review explores the multifaceted roles of cancer‐associated fibroblasts (CAFs) in tumor biology. It examines their diverse origins, dynamic activation via signaling pathways, and spatial–temporal heterogeneity, proposing an updated classification of eight distinct CAF subtypes. The review highlights CAFs' contributions to tumor growth, metastasis,
Chang Fan, Wenlong Zhu, Yuan Chen, Wanwan Zhu, Jin Ding   +4 more
wiley   +1 more source

Complement dysregulation in human tauopathies

Brain Pathology, Volume 35, Issue 6, November 2025.
Complement protein and activation product levels were assessed in post‐mortem frontal cortex from three distinct subtypes of Tauopathy: Corticobasal degeneration, globular glial tauopathy, and Pick's disease. Quantification of complement proteins by immunohistochemistry and ELISA showed elevation of key complement proteins (C1q) regulators (FI) and ...
Jacqui Nimmo, Samuel Keat, Louis De Muynck, B. Paul Morgan   +3 more
wiley   +1 more source

Serum Biomarkers in Atlantic Salmon for Differential Diagnosis of Cardiomyopathy Syndrome and Pancreas Disease: Proteomic Identification of Serum Fibrinogen to Enhance Troponin Immunoassay as Optimal Diagnostic Approach

Journal of Fish Diseases, Volume 48, Issue 11, November 2025.
ABSTRACT Cardiac viral diseases are among the major causes of economic losses in Atlantic salmon (Salmo salar L.) aquaculture. These include cardiomyopathy syndrome (CMS) caused by piscine myocarditis virus (PMCV) and pancreas disease (PD) caused by Atlantic salmonid alphavirus (SAV).
Francesca Riva, Lauren Elaine Black, Kim D. Thompson, Philippe Sourd, Andrei Bordeianu, Christopher C. Chadwick, Hooman Moghadam, Jorge Del‐Pozo, Janina Costa, Richard Burchmore, Nicola Brady, Lewis Moore, Suzanne McGill, Mark McLaughlin, Peter David Eckersall   +14 more
wiley   +1 more source

The asparagine-linked sugar chains of subcomponent C1q of the first component of human complement.

, 1978
Tsuguo Mizuochi, Kunio Yonemasu, Koji Yamashita, Akira Kobata   +3 more
openalex   +1 more source

Activation of the first component of complement, C1, by a monoclonal antibody recognizing the C chain of C1q. [PDF]

, 1984
Hans‐Peter Heinz, Reinhard Bürger, M. Golan, Michael Loos   +3 more
openalex   +1 more source

RNA Granules at the Crossroads of Synaptic Dysfunction and Neurodegeneration

Journal of Neurochemistry, Volume 169, Issue 11, November 2025.
Under physiological conditions, neuronal RNA granules (e.g., transport granules, activity‐dependent granules, processing bodies, and stress granules) cooperate to regulate mRNA transport, storage, and localized translation, thereby sustaining synaptic and neuronal functions.
Rita Nóbrega‐Martins, Beatriz Barros‐Santos, Georgia Papadimitriou, Ioannis Sotiropoulos, Benjamin Wolozin, Joana Margarida Silva   +5 more
wiley   +1 more source

Structural and functional studies in C1q deficiency. [PDF]

, 1982
Rose Marie Chapuis, G. Hauptmann, E Grosshans, H. Isliker   +3 more
openalex   +1 more source

Proangiogenic properties of complement protein C1q can contribute to endometriosis

Frontiers in Immunology
Endometriosis (EM) is defined as the engraftment and proliferation of functional endometrial-like tissue outside the uterine cavity, leading to a chronic inflammatory condition.
Chiara Agostinis, Miriam Toffoli, Gabriella Zito, Andrea Balduit, Silvia Pegoraro, Mariagiulia Spazzapan, Lorella Pascolo, Federico Romano, Giovanni Di Lorenzo, Alessandro Mangogna, Aurora Santin, Beatrice Spedicati, Beatrice Spedicati, Erica Valencic, Giorgia Girotto, Giorgia Girotto, Giuseppe Ricci, Giuseppe Ricci, Uday Kishore, Uday Kishore, Roberta Bulla   +20 more
doaj   +1 more source