Results 11 to 20 of about 68,566 (325)
Frontiers in Neuroscience, 2021 ObjectiveComplement activation is instrumental in the pathogenesis of Hypoxic-ischemic encephalopathy (HIE), a significant cause of neonatal mortality and disability worldwide.
Tushar A. Shah +9 more
doaj +1 more source
Science Advances, 2023 Sepsis-associated encephalopathy (SAE) is a severe and frequent complication of sepsis causing delirium, coma, and long-term cognitive dysfunction. We identified microglia and C1q complement activation in hippocampal autopsy tissue of patients with ...
Ha-Yeun Chung +23 more
semanticscholar +1 more source
The role of complement component C1q in angiogenesis
Exploration of Immunology, 2023 The complement component C1q plays a role as a pro-angiogenic factor in different contexts, acting in a complement-independent way. For example, this molecule is able to foster the remodeling of the spiral arteries for a physiological pregnancy and to ...
Mariagiulia Spazzapan +3 more
doaj +1 more source
Journal for ImmunoTherapy of Cancer, 2023 Background Although immune checkpoint blockade (ICB) therapy has shown remarkable benefits in cancers, a subset of patients with cancer exhibits unresponsiveness or develop acquired resistance due to the existence of abundant immunosuppressive cells ...
Siyu Zhang +10 more
semanticscholar +1 more source
eLife, 2020 The ability of a well-known component of the complement cascade to bind to a variety of receptors has implications for signaling biology, spinal cord injury and, possibly, the evolution of the complement system.
Mark Noble, Christoph Pröschel
openaire +4 more sources
Nature Aging, 2022 Microglia and complement can mediate neurodegeneration in Alzheimer’s disease (AD). By integrative multi-omics analysis, here we show that astrocytic and microglial proteins are increased in TauP301S synapse fractions with age and in a C1q-dependent ...
Borislav Dejanovic +21 more
semanticscholar +1 more source
Complement Component C1q as an Emerging Biomarker for the Diagnosis of Tuberculous Pleural Effusion
Frontiers in Microbiology, 2021 Background and Objective: The accurate differential diagnosis of tuberculous pleural effusion (TPE) from other exudative pleural effusions is often challenging.
Xin Qiao +3 more
doaj +1 more source
Proceedings of the National Academy of Sciences of the United States of America, 2022 Significance Behçet’s disease (BD) is a systemic vasculitis, and its pathogenesis is elusive. Limited understanding of the immune disturbances in BD hindered the identification of therapeutic targets.
Wenjie Zheng +15 more
semanticscholar +1 more source
Change in C1q deposition in C1q nephropathy [PDF]
Pediatric Nephrology, 2009 Sirs, We read with interest the article entitled “A single-center study of C1q nephropathy in children” by Roberti et al. in the latest issue of this journal [1]. They reviewed the records of 14 children with C1q nephropathy (C1qN) and found a high incidence in pediatric patients (14/264, 5.3%), with variable clinical presentation.
Ken Hatae +4 more
openaire +3 more sources