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Ultrastructure of Human C1q Protein [PDF]
Nature New Biology, 1972 THE first component (C1) in the complement system may be defined functionally as a macromolecule capable of binding to antigen-antibody complexes and inducing the sequential reactions of this system. C1 consists of three distinct proteins named C1q, C1r and C1s which,in serum, form a macromolecular complex held together by calcium ions1.
Sven‐Eric Svehag, L. MANHEM, B. Bloth
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Science Advances, 2023 Sepsis-associated encephalopathy (SAE) is a severe and frequent complication of sepsis causing delirium, coma, and long-term cognitive dysfunction. We identified microglia and C1q complement activation in hippocampal autopsy tissue of patients with ...
Ha-Yeun Chung +23 more
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The role of complement component C1q in angiogenesis
Exploration of Immunology, 2023 The complement component C1q plays a role as a pro-angiogenic factor in different contexts, acting in a complement-independent way. For example, this molecule is able to foster the remodeling of the spiral arteries for a physiological pregnancy and to ...
Mariagiulia Spazzapan +3 more
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Journal for ImmunoTherapy of Cancer, 2023 Background Although immune checkpoint blockade (ICB) therapy has shown remarkable benefits in cancers, a subset of patients with cancer exhibits unresponsiveness or develop acquired resistance due to the existence of abundant immunosuppressive cells ...
Siyu Zhang +10 more
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eLife, 2020 The ability of a well-known component of the complement cascade to bind to a variety of receptors has implications for signaling biology, spinal cord injury and, possibly, the evolution of the complement system.
Mark Noble, Christoph Pröschel
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Nature Aging, 2022 Microglia and complement can mediate neurodegeneration in Alzheimer’s disease (AD). By integrative multi-omics analysis, here we show that astrocytic and microglial proteins are increased in TauP301S synapse fractions with age and in a C1q-dependent ...
Borislav Dejanovic +21 more
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Proceedings of the National Academy of Sciences of the United States of America, 2022 Significance Behçet’s disease (BD) is a systemic vasculitis, and its pathogenesis is elusive. Limited understanding of the immune disturbances in BD hindered the identification of therapeutic targets.
Wenjie Zheng +15 more
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Complement Component C1q as an Emerging Biomarker for the Diagnosis of Tuberculous Pleural Effusion
Frontiers in Microbiology, 2021 Background and Objective: The accurate differential diagnosis of tuberculous pleural effusion (TPE) from other exudative pleural effusions is often challenging.
Xin Qiao +3 more
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Blood, 2022 Key Points • C1Q+ cells represent a highly tissue-infiltrative leukemia population and could reconstitute EMI phenotype of AML.• Fibroblast attracts C1Q+ leukemia cell via C1Q–globular C1Q receptor recognition and stimulation of transforming growth ...
Li-Xue Yang +18 more
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