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Diagnostic Problems in C3 Glomerulopathy [PDF]

Biomedicines, 2023
Background: C3 glomerulopathies (C3GN) are a group of rare kidney diseases associated with impaired complement regulation. The effects of this disease include the accumulation of complement C3 in the kidneys. Based on the clinical data, as well as light,
Leszek Niepolski, Anna Czekała, Monika Seget-Dubaniewicz, Magdalena Frydrychowicz, Patrycja Talarska-Markiewicz, Angelika Kowalska, Jagoda Szmelter, Wiesława Salwa-Żurawska, Tomasz Sirek, Dawid Sobański, Beniamin Oskar Grabarek, Jakub Żurawski   +11 more
doaj   +4 more sources

C3 Glomerulopathy: Novel Treatment Paradigms [PDF]

Kidney International Reports
C3 glomerulopathy (C3G) is diagnosed by kidney biopsy, with immunofluorescence showing isolated or dominant C3 staining, indicating hyperactivity of the alternative complement pathway as the key driver of glomerular injury.
Blanca Tarragon Estebanez, Andrew S. Bomback   +1 more
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Pathology of C3 Glomerulopathy [PDF]

Childhood Kidney Diseases, 2019
C3 glomerulopathy is a renal disorder involving dysregulation of alternative pathway complement activation. In most instances, a membranoproliferative pattern of glomerular injury with a prevalence of C3 deposition is observed by immunofluorescence ...
Su-Jin Shin, Yoonje Seong, Beom Jin Lim
doaj   +4 more sources

Eculizumab in C3 Glomerulopathy: A Systematic Review of Therapeutic Efficacy and Clinical Outcomes [PDF]

Pharmaceutics
Background: C3 glomerulopathies (C3G), including dense deposit disease (DDD) and C3 glomerulonephritis (C3GN), are rare kidney disorders driven by dysregulation of the alternative complement pathway.
Dominik Lewandowski, Mateusz Konieczny, Krzysztof Chrzanowski, Marta Jakubowska, Zuzanna Paryzek, Miłosz Miedziaszczyk, Ilona Idasiak-Piechocka   +6 more
doaj   +2 more sources

C3 Glomerulopathy Diagnosis, Current Treatments, and Emerging Therapies [PDF]

Kidney Medicine
C3 glomerulopathy (C3G) is characterized by prominent deposition of complement component C3 in the kidney glomeruli, leading to glomerular inflammation.
Mahtab Mashayekhi, Jonathan E. Zuckerman, Jonathan Barratt, Richard J. Glassock, Fernando Caravaca-Fontán, Raymond K. Hsu, Arun Rajasekaran, Edgar Lerma, Sahibzadi Mahrukh Noor, Amir Abdipour, Sayna Norouzi   +10 more
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C3 glomerulopathy is highly prevalent in French Polynesia [PDF]

Journal of Translational Autoimmunity
Objective: To compare the natural history of C3 glomerulopathy (C3G) to acute post-infectious glomerulonephritis (APIGN) in a cohort of patients with a relative homogeneity of environment conditions and genetic background.
Nelly Candela, Nicolas Benichou, Mathilde Lefebvre, Lorraine Gueguen, Paula Vieira-Martins, Carine El Sissy, Hervé Sartelet, Pascale Testevuide, Ronan Delaval, Stanislas Faguer   +9 more
doaj   +2 more sources

Pregnancy outcomes in C3 glomerulopathy: a retrospective review [PDF]

BMC Nephrology
Background C3 Glomerulopathy (C3G) is an ultra-rare glomerular disease driven by dysregulation of the alternative pathway of complement. 30–50% of adult patients progress to end stage kidney disease (ESKD) within 10 years of diagnosis. Little is known of
Lauren O. Fergus, Meryl Waldman, Monica D. Hall, Lynn Vining, Jillian Hall, Tina Liu, Yuzhou Zhang, Patrick J. Walker, Richard J. H. Smith, Carla M. Nester   +9 more
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Clinical characteristics and short term outcomes of childhood immune complex membranoproliferative glomerulonephritis and C3 glomerulopathy: a single centre retrospective study [PDF]

BMC Nephrology
Background Membranoproliferative glomerulonephritis, with its immune complex variety and C3 glomerulopathy, is a rare glomerular disease in children. The objective of this study was to determine the clinical features and short-term outcomes in children ...
Irshad Ali Bajeer, Sabeeta Khatri, Pawan Kumar, Seema Hashmi, Mohammed Mubarak, Ali Asghar Lanewala   +5 more
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Heterozygous laminin β2 mutation in C3 glomerulopathy

Saudi Journal of Kidney Diseases and Transplantation, 2021
C3 glomerulopathy is usually seen with the presence of C3 nephritic factor, homozygous or heterozygous mutations in the regulatory complement proteins factor H, factor I, or C3. We describe the presence of heterozygous laminin β2 mutation in a patient of
Manish R Balwani, Amit S Pasari, Amol R Bhawane, Priyanka R Tolani   +3 more
doaj   +1 more source

C3 glomerulopathy associated with both hypertensive retinopathy and purtscher-like retinopathy

American Journal of Ophthalmology Case Reports, 2022
Purpose: This article reports the case of a 21-year-old woman with both hypertensive retinopathy and Purtscher-like retinopathy in association with C3 glomerulopathy.
Moosa Zaidi, Kapil Mishra, Huy Vu Nguyen, Paul Peter Miller, Hashem Ghoraba, Irmak Karaca, Wataru Matsumiya, Quan Dong Nguyen, Loh-Shan Bryan Leung   +8 more
doaj   +1 more source