Results 11 to 20 of about 4,208 (171)
C3 glomerulopathy [version 1; referees: 4 approved] [PDF]
F1000Research, 2017 C3 glomerulopathy is a recently defined entity that encompasses a group of kidney diseases caused by abnormal control of complement activation with deposition of complement component C3 in glomeruli leading to variable glomerular inflammation. Before the
H. Terence Cook
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Treating C3 glomerulopathy with eculizumab [PDF]
BMC Nephrology, 2018 Background C3 glomerulopathy (C3G) is a rare, but severe glomerular disease with grim prognosis. The complex pathogenesis is just unfolding, and involves acquired as well as inherited dysregulation of the alternative pathway of the complement cascade ...
Thomas Welte +7 more
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Remissions and progression of C3 glomerulopathy
Терапевтический архив, 2022 Aim. To analyze the outcomes of C3-glomerulopathy (C3-GP) and determine the associated factors. Materials and methods. A retrospective single-center study included 60 patients with newly diagnosed C3-GP (with primary C3-GP pC3-GP 82%). Of these, 48 (
Anna V. Karunnaya +1 more
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Cleveland Clinic Journal of Medicine, 2023 C3 glomerulopathy (C3G) is a rare kidney disease that causes kidney dysfunction as a result of dysregulation of the complement system alternate pathway (AP). C3G encompasses 2 separate disorders, C3 glomerulonephritis and dense deposit disease. The presentation and natural history is variable and kidney biopsy is needed to confirm the diagnosis.
Ali, Mehdi, Jonathan J, Taliercio
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Acquired drivers of C3 glomerulopathy. [PDF]
Clin Kidney JAbstract C3 glomerulopathy (C3G) is a group of heterogeneous ultrarare kidney diseases characterized by dysregulated activation of the complement alternative pathway (AP) leading to excessive C3 cleavage. Diagnosis relies on kidney biopsy showing predominant C3 deposition in the glomerular basement membrane, with electron microscopy ...
Welsh SJ, Zhang Y, Smith RJH.
europepmc +3 more sources
Recurrence of rare disease after kidney transplant [PDF]
Journal of Nephropharmacology, 2023 The incidence of chronic kidney diseases (CKDs) by rare etiologies is growing along with other CKDs. This mini-review discusses the epidemiology, pathogenesis, clinical presentation, and diagnosis of rare kidney disease recurrence after kidney ...
Farahnoosh Farnood +4 more
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BMC Nephrology, 2018 Background Complement component 3 (C3) glomerulopathy, which includes dense deposit disease (DDD) and C3 glomerulonephritis, is caused by dysregulation of the alternative complement pathway.
Shuma Hirashio +7 more
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Characterization of C3 in C3 glomerulopathy [PDF]
Nephrology Dialysis Transplantation, 2016 Abstract Background: C3 glomerulopathy (C3G) is caused by overactivity of the alternative pathway of complement that results in bright glomerular C3 staining with minimal or no deposition of immunoglobulins on immunofluorescence microscopy.
Sanjeev, Sethi +7 more
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Update on C3 glomerulopathy [PDF]
Nephrology Dialysis Transplantation, 2014 C3 glomerulopathy refers to a disease process in which abnormal control of complement activation, degradation or deposition results in predominant C3 fragment deposition within the glomerulus and glomerular damage. Recent studies have improved our understanding of its pathogenesis.
Barbour, TD, Ruseva, MM, Pickering, MC
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Case Reports in Nephrology and Dialysis, 2018 The advances in our understanding of the alternative pathway have emphasized that uncontrolled hyperactivity of this pathway causes 2 distinct disorders that adversely impact the kidney.
Ravneet Bajwa +10 more
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