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Clinical Journal of the American Society of Nephrology, 2014 Summary Background and objectives The term C3 glomerulopathy describes renal disorders characterized by the presence of glomerular deposits composed of C3 in the absence of significant amounts of Ig. On the basis of electron microscopy appearance, subsets of C3 glomerulopathy include dense deposit disease (DDD) and C3
Nicholas R, Medjeral-Thomas +14 more
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Glomerular C4d Staining Does Not Exclude a C3 Glomerulopathy
Kidney International Reports, 2019 Introduction: C4d, an early product in the classical/lectin complement pathway has shown potential in the evaluation of C3 glomerulopathy where its absence would support an alternative pathway abnormality.
Geetika Singh +11 more
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Diverse Clinical Presentations of C3 Dominant Glomerulonephritis
Frontiers in Medicine, 2020 C3 dominant immunofluorescence staining is present in a subset of patients with idiopathic immune complex membranoproliferative glomerulonephritis (iMPGN).
Ramy M. Hanna +13 more
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Kidney International Reports, 2019 Introduction: Transplant glomerulopathy (TG) becomes increasingly prevalent in kidney transplant recipients over time, and it is strongly associated with allograft failure.
Sarah E. Panzer +5 more
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Recent insights into C3 glomerulopathy [PDF]
Nephrology Dialysis Transplantation, 2013 'C3 glomerulopathy' is a recent disease classification comprising several rare types of glomerulonephritis (GN), including dense deposit disease (DDD), C3 glomerulonephritis (C3GN) and CFHR5 nephropathy. These disorders share the key histological feature of isolated complement C3 deposits in the glomerulus. A common aetiology involving dysregulation of
Barbour, TD, Pickering, MC, Cook, HT
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C3 glomerulopathy in cystic fibrosis: a case report
BMC Nephrology, 2018 Background C3 glomerulonephritis is a rare glomerulopathy characterized at renal biopsy by C3 deposition, alone or with scanty immunoglobulins, as well as by an electron-dense material in mesangium, subendothelial and subepithelial space.
Domenico Santoro +9 more
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C3 glomerulopathy and current dilemmas [PDF]
Clinical and Experimental Nephrology, 2016 C3 glomerulopathy (C3G) is a recently identified disease entity caused by dysregulation of the alternative complement pathway, and dense deposit disease (DDD) and C3 glomerulonephritis (C3GN) are its components. Because laboratory detection of complement dysregulation is still uncommon in practice, "dominant C3 deposition by two orders greater than ...
Naoko Ito, Ryuji Ohashi, Michio Nagata
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, 2018 <p>C3 glomerulopathy (C3G) encompasses a group of severe renal diseases characterized by “dominant C3” deposition in the renal glomerulus. Patients typically present as nephritic nephrotics, with hematuria, hypertension, heavy proteinuria and edema.
Xue Xiao +5 more
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C3 glomerulopathies: dense deposit disease and C3 glomerulonephritis
Frontiers in Medicine, 2023 Dense deposit disease (DDD) and C3 glomerulonephritis (C3GN) are types of membranoproliferative glomerulonephritis classified as C3 glomerulopathies. These conditions are characterized by an increased number of intraglomerular cells and diffuse thickening of the glomerular capillary walls, along with the deposition of C3 and minimal or absent ...
Claudio Ponticelli +4 more
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Nefrología (English Edition), 2018 The activation of the alternative pathway of the complement is involved in the development of several renal diseases, such as atypical haemolytic uraemic syndrome and C3 glomerulopathy. In C3 glomerulopathy, a high percentage of patients have circulating
Fernando Corvillo +1 more
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