Results 61 to 70 of about 4,208 (171)

C3-Glomerulopathy Autoantibodies Mediate Distinct Effects on Complement C3- and C5-Convertases

Frontiers in Immunology, 2019
C3 glomerulopathy (C3G) is a severe kidney disease, which is caused by defective regulation of the alternative complement pathway. Disease pathogenesis is heterogeneous and is caused by both autoimmune and genetic factors.
Fei Zhao, Sara Afonso, Susanne Lindner, Andrea Hartmann, Ina Löschmann, Bo Nilsson, Kristina N. Ekdahl, Lutz T. Weber, Sandra Habbig, Gesa Schalk, Michael Kirschfink, Peter F. Zipfel, Peter F. Zipfel, Christine Skerka   +13 more
doaj   +1 more source

Applying Genetic Risk Score to Improve Risk Assessment of New‐Onset Lupus Nephritis in Systemic Lupus Erythematosus: A Large‐Scale Prospective Cohort Study

MedComm, Volume 6, Issue 12, December 2025.
ABSTRACT Lupus nephritis (LN) is one of the most severe manifestation of systemic lupus erythematosus (SLE). However, reliable tools for predicting LN risk remain limited. In this multicenter prospective cohort study, we developed, validated, and refined a risk stratification model for new‐onset LN.
Yufang Ding, Mucong Li, Wei Bai, Junyan Qian, Mengzhuo Cao, Jian Xu, Xinwang Duan, Hui Luo, Cheng Zhao, Feng Zhan, Min Yang, Rui Wu, Lijun Wu, Zhen Chen, Wei Wei, Yang Xu, Shangzhu Zhang, Xiaomei Leng, Qian Wang, Xinping Tian, Pei Gao, Xiaofeng Zeng, Xinzhuang Yang, Mengtao Li, Jiuliang Zhao   +24 more
wiley   +1 more source

Collapsing Glomerulopathy in Brazil: A Nationwide Descriptive Study

Nephrology, Volume 30, Issue 12, December 2025.
This multicenter study describes the characterization and outcomes of a retrospective cohort of collapsing glomerulopathy cases conducted in Brazil. These findings reinforce the understanding of this rare glomerulopathy. ABSTRACT Aim Collapsing glomerulopathy (CG) is a glomerular disease that progresses rapidly to renal replacement therapy (RRT ...
Marcos Adriano Garcia Campos, Precil Diego Miranda de Meneses Neves, Érico Murilo Monteiro Cutrim, Andressa Monteiro Sodré, João Victor Carvalho, Davi Campos Wanderley, Stanley de Almeida Araújo, Ricardo Miranda Borges, Luiz Fernando Onuchic, Andréia Watanabe, Irene de Lourdes Noronha, Vanessa dos Santos Silva, Igor Denizarde Bacelar Marques, Felipe Leite Guedes, José Bruno de Almeida, Rafael Fernandes Vanderlei Vasco, Antônio Monteiro, Francisco Rasiah Ladchumananandasivam, Orlando Vieira Gomes, Antonio Augusto Lima Teixeira Júnior, Karla Cristina Petruccelli Israel, Denise Maria do Nascimento Costa, Fernanda Pinheiro Martin Tapioca, Epitácio Rafael da Luz Neto, Joyce Santos Lages, Natalino Salgado Filho, Gyl Eanes Barros Silva   +26 more
wiley   +1 more source

Proteinuria After Kidney Transplantation

Pediatric Transplantation, Volume 29, Issue 8, December 2025.
ABSTRACT Proteinuria is a relatively frequent complication in both adults and children after kidney transplantation (40%–80%). It is usually mild and predominantly of tubular origin and is caused mainly by rejection, mTOR inhibitors, or hypertension; however, proteinuria could also be in the nephrotic range and of glomerular origin if caused by the ...
Tomas Seeman, Robert L. Myette, Janusz Feber, Massimiliano Bertacchi, Raja Sekhar Dandamudi, Daniella Levy Erez, Anja Buescher   +6 more
wiley   +1 more source

Current concepts in C3 glomerulopathy

Indian Journal of Nephrology, 2014
Complement component 3 glomerulopathy (C3G) is a recently defined entity comprising of dense deposit disease and C3 glomerulonephritis. The key histological feature is the presence of isolated C3 deposits without immunoglobulins. Often masqueradng as some of the common glomerulonephritides this is a prototype disorder occurring from dysregulated ...
Thomas, S., Ranganathan, D., Francis, L., Madhan, K., John, G. T.   +4 more
openaire   +2 more sources

The Impact of Complement Factor H‐Related Protein Gene Deletions on Kidney Transplantation

Scandinavian Journal of Immunology, Volume 102, Issue 6, December 2025.
In this study, we found that rs7542235 allele G tags a deletion of the CFHR1 gene. We also found that rs6677604 allele A tags a deletion of the whole CFHR3–1 locus. The plasma proteomics studies show that both variants are associated with an altered expression of FH/FHR proteins thus revealing a novel level of intricate regulation of the complement ...
Salla Markkinen, A. Inkeri Lokki, Ilkka Helanterä, Jarmo Ritari, Jukka Partanen, Seppo Meri, Kati Hyvärinen   +6 more
wiley   +1 more source

World Association for Veterinary Dermatology Consensus Statement for Diagnosis, and Evidence‐Based Clinical Practice Guidelines for Treatment and Prevention of Canine Leishmaniosis

Veterinary Dermatology, Volume 36, Issue 6, Page 723-787, December 2025.
Hyperkeratosis of (a) the footpads and (b) the nasal planum. ABSTRACT Background Canine leishmaniosis (CanL) due to Leishmania infantum remains common, and veterinarians do not always follow scientifically sound approaches for diagnosis, treatment and prevention. Objectives To provide consensus guidelines for diagnosis and evidence‐based guidelines for
Manolis N. Saridomichelakis, Gad Baneth, Silvia Colombo, Filipe Dantas‐Torres, Lluís Ferrer, Alessandra Fondati, Guadalupe Miró, Laura Ordeix, Domenico Otranto, Chiara Noli   +9 more
wiley   +1 more source

IgG‐Secreting Lymphoplasmacytic Lymphoma Presenting With Massive Kidney Infiltration

Clinical Case Reports, Volume 13, Issue 11, November 2025.
ABSTRACT Various factors related to lymphoplasmacytic lymphoma (LPL) can lead to kidney complications; however, LPL‐related kidney complications are not as well‐described as those with multiple myeloma. Here, we report a case of IgG‐secreting LPL presenting with acute kidney injury owing to direct tumor infiltration.
Yuichi Nakamura, Yoshihiro Itoh, Tomoyuki Sakamoto, Emi Kakegawa, Yasuhito Terui, Taichi Tarusawa, Tsutomu Inoue, Hirokazu Okada, Keisuke Ishizawa, Taketo Yamada   +9 more
wiley   +1 more source

A Case of Myeloproliferative Neoplasm‐Associated Glomerulopathy in a Patient With Myelofibrosis

Clinical Case Reports, Volume 13, Issue 11, November 2025.
ABSTRACT Myeloproliferative neoplasm (MPN)‐related glomerulopathy is a rare, late complication of MPN. Mesangial matrix expansion seems to be the histopathological hallmark. Proteinuria may not always be present. Further exploration is warranted to determine whether risk factors—including disease entity, mutation status and treatment regimens ...
Saskia Leibowitz, Michelle Spanevello, Leo Francis, Prianka Puri, Kirsten Hepburn   +4 more
wiley   +1 more source

Glomerular Complement Factor H–Related Protein 5 (FHR5) Is Highly Prevalent in C3 Glomerulopathy and Associated With Renal Impairment

Kidney International Reports, 2019
Introduction: Therapeutic agents that target complement are increasingly available for glomerular diseases. However, the mechanisms linking glomerular complement deposition with inflammation and damage are incompletely understood.
Nicholas R. Medjeral-Thomas, Hilary Moffitt, Hannah J. Lomax-Browne, Nicholas Constantinou, Tom Cairns, H. Terence Cook, Matthew C. Pickering   +6 more
doaj   +1 more source