Results 71 to 80 of about 4,208 (171)
Nephrology, Volume 30, Issue 11, November 2025.Key findings: This study confirmed that the glomerulopathy in CLU‐KO B6 mice was similar to the pathological features of ITG and may be therefore considered as an experimental model of ITG. Further, CLU may negatively regulate the fibrillogenesis of ITG.
Xinglan Li +6 more
wiley +1 more source
Case Reports in Nephrology and Dialysis, 2017 Membranoproliferative glomerulonephritis (MPGN) is a histopathologic diagnosis causing microscopic hematuria, nephrotic range proteinuria, and chronic renal failure.
Rehan Shah +2 more
doaj +1 more source
Post‐ischemia and reperfusion kidney injury is mitigated in a novel complement 5 knockout rat
Physiological Reports, Volume 13, Issue 21, November 2025.Abstract Ischemia‐reperfusion injury (IRI) is the central contributing factor to acute kidney injury (AKI). Kidney tissue that becomes necrotic during this process releases a variety of pro‐inflammatory factors, driving activation of the complement cascade.
Madison McGraw +7 more
wiley +1 more source
Mycophenolate Mofetil Treatment of C3 Glomerulopathy
Clinical Journal of the American Society of Nephrology, 2020 C3 glomerulopathy is a relatively newly described and rare disease mediated by dysregulated activity of the alternative complement pathway. Although the light and electron microscopic findings may vary, the disease is defined by immunofluorescence microscopy with glomerular deposition ...
Yonatan Peleg, Gerald B. Appel
openaire +3 more sources
Inhibition of AMPKα Pathway by Podocyte GOLM1 Exacerbates Diabetic Nephrology in Mice
Advanced Science, Volume 12, Issue 37, October 6, 2025.Podocyte Golgi membrane protein 1 interacts with epidermal growth factor receptor to inhibit peroxisome proliferator activated receptor γ, and then inactivates adenosine monophosphate activated protein kinase α pathway, which facilitates diabetes‐related inflammation, oxidative damage, apoptosis, and renal dysfunction.
Peng Xu +14 more
wiley +1 more source
Frontiers in ImmunologyC3 glomerulopathy encompasses a group of glomerular diseases characterized by the predominant deposition of complement component C3 on kidney biopsy without significant immunoglobulin staining.
Wenjing Cai +13 more
doaj +1 more source
Factor B and C4b2a Autoantibodies in C3 Glomerulopathy
Frontiers in Immunology, 2019 C3 Glomerulopathy (C3G) is a renal disease mediated primarily by dysregulation of the alternative pathway of complement. Complement is the cornerstone of innate immunity.
Jill J. Hauer +4 more
doaj +1 more source
Dense Deposit Disease and C3 Glomerulopathy
Seminars in Nephrology, 2013 C3 glomerulopathy refers to those renal lesions characterized histologically by predominant C3 accumulation within the glomerulus, and pathogenetically by aberrant regulation of the alternative pathway of complement. Dense deposit disease is distinguished from other forms of C3 glomerulopathy by its characteristic appearance on electron microscopy. The
Barbour, Thomas D. +2 more
openaire +2 more sources
The many faces of C3 glomerulopathy [PDF]
Kidney International, 2012 To the Editor: The recent article by Sethi et al., ‘Membranoproliferative glomerulonephritis and C3 glomerulopathy: resolving the confusion’, made me revisit a 12-year-old publication. In ‘Apparent progression of acute glomerulonephritis to dense deposit disease’ we described an 8-year-old boy with hypocomplementemia and meningococcemia.
openaire +2 more sources
Proof of concept of a new plasma complement Factor H from waste plasma fraction
Frontiers in ImmunologyIntroductionComplement factor H (FH) is a major regulator of the complement alternative pathway, its mutations predispose to an uncontrolled activation in the kidney and on blood cells and to secondary C3 deficiency.
Filippo Mori +15 more
doaj +1 more source