Results 101 to 110 of about 7,153 (219)

Disruption of the C5a/C5aR1 axis confers protection against hookworm infection in lung

Frontiers in Immunology
Hookworms are soil-transmitted parasitic nematodes that penetrate the host skin before migrating to the lungs. With an estimated 500-700 million people infected worldwide, hookworm infections are a neglected tropical disease and a significant cause of ...
Sarah Walachowski, Sarah Walachowski, Lucien Garo, Arjun Sharma, Arjun Sharma, Arjun Sharma, Archana Jayaraman, Jason Noon, Christoph Reinhardt, Markus Bosmann, Markus Bosmann   +10 more
doaj   +1 more source

3′mRNA sequencing reveals pro-regenerative properties of c5ar1 during resolution of murine acetaminophen-induced liver injury

npj Regenerative Medicine, 2022
Murine acetaminophen-induced acute liver injury (ALI) serves as paradigmatic model for drug-induced hepatic injury and regeneration. As major cause of ALI, acetaminophen overdosing is a persistent therapeutic challenge with N-acetylcysteine clinically ...
Sina Gonther, Malte Bachmann, Itamar Goren, Arnaud Huard, Andreas Weigert, Jörg Köhl, Heiko Mühl   +6 more
doaj   +1 more source

An Immunoregulatory Role for Complement Receptors in Murine Models of Breast Cancer

Antibodies, 2021
The complement system has demonstrated roles in regulating tumor growth, although these may differ between tumor types. The current study used two murine breast cancer models (EMT6 and 4T1) to investigate whether pharmacological targeting of receptors ...
Fazrena Nadia Md Akhir, Mohd Hezmee Mohd Noor, Keith Weng Kit Leong, Jamileh A. Nabizadeh, Helga D. Manthey, Stefan E. Sonderegger, Jenny Nga Ting Fung, Crystal E. McGirr, Ian A. Shiels, Paul C. Mills, Trent M. Woodruff, Barbara E. Rolfe   +11 more
doaj   +1 more source

Integrative cross‐tissue and spatially resolved single‐cell profiling uncovers tumour‐educated inflammatory remodelling of tissue‐resident macrophage ecosystem with immunotherapeutic prognostic significance in pan‐cancer

Clinical and Translational Medicine, Volume 16, Issue 2, February 2026.
Pan‐cancer analysis reveals an inflammatory phenotype remodeling of tissue‐resident macrophages (iTRM) in the tumor microenvironment, which is associated with immunosuppression. Tissue‐resident macrophages and monocyte‐derived macrophages exhibit convergent differentiation toward a similar inflammatory phenotype. iTRM‐enriched ecosystems are associated
Weikai Wang, Zibin Chen, Yuhan Huang, Zhihao Hu, Peixin Zhu, Zhuoli Huang, Jingzhi Lv, Ziru Liao, Yuhui Zheng, Chen Wei, Baibing Guan, Yin Zeng, Xinyue Zhu, Yafei Yang, Guibo Li, Xin Jin, Xi Chen, Xiao Yang, Zikun Ma, Jianhua Yin   +19 more
wiley   +1 more source

Distinct roles of the anaphylatoxin receptors C3aR, C5aR1 and C5aR2 in experimental meningococcal infections

Virulence, 2019
The complement system is pivotal in the defense against invasive disease caused by Neisseria meningitidis (Nme, meningococcus), particularly via the membrane attack complex.
Marcel Muenstermann, Lea Strobel, Andreas Klos, Rick A. Wetsel, Trent M. Woodruff, Jörg Köhl, Kay O. Johswich   +6 more
doaj   +1 more source

Bufalin Inhibits Cytokine Storm by Regulating TLR4/TLR3 Signaling Pathway

Immunity, Inflammation and Disease, Volume 14, Issue 2, February 2026.
ABSTRACT Background Bufalin is one main component of the dried venom from Bufo gargarizans Cantor, which has anti‐tumor, cardiotonic, anti‐inflammatory and other physiological activities. However, in recent years, researchers have mainly paid attention to its anti‐tumor effect and neglected its anti‐inflammatory effect.
Xixi Liu, Chencheng Li, Jing Yang, Weiguang Zhang, Zhongxiao Hu, Xiaoli Zhang, Reaila Jianati, Fang Tian, Xingbin Dai, Zuqiong Xu, Biqing Chen, Xuejun Zhu   +11 more
wiley   +1 more source

The effects of C5aR1 on leukocyte infiltration following pilocarpine‐induced status epilepticus [PDF]

Epilepsia, 2017
SummaryThis study aimed to determine the role C5aR1 plays in mediating immune responses acutely after pilocarpine‐induced status epilepticus (SE), specifically those of brain‐infiltrating leukocytes. Three days following pilocarpine SE, we determined by flow cytometry the brain immune cell phenotypes and measured key proinflammatory and ...
Benson, Melissa J., Manzanero, Silvia, Borges, Karin   +2 more
openaire   +3 more sources

By Increasing the Expression and Activation of STAT3, Sustained C5a Stimulation Increases the Proliferation, Migration, and Invasion of RCC Cells and Promotes the Growth of Transgrafted Tumors

Cancer Management and Research, 2021
Jing-Min Zheng,1,* Han-Xi Zhou,1,* Hong-Yuan Yu,1,* Yu-Hui Xia,2 Qing-Xin Yu,2 Hang-Shuai Qu,1 Jia-Qian Bao1 1Department of Urology, Taizhou Hospital, Wenzhou Medical University, Linhai, Zhejiang, People’s Republic of China; 2Department of ...
Zheng JM, Zhou HX, Yu HY, Xia YH, Yu QX, Qu HS, Bao JQ   +6 more
doaj  

Isolation site influences virulence phenotype of serotype 14 Streptococcus pneumoniae strains belonging to multilocus sequence type 15 [PDF]

, 2015
Streptococcus pneumoniae is a diverse species causing invasive as well as localized infections that result in massive global morbidity and mortality. Strains vary markedly in pathogenic potential, but the molecular basis is obscured by the diversity and ...
Amin, Zarina, Harvey, Richard M., Hughes, Catherine E., Paton, Adrienne W., Paton, James C., Trappetti, Claudia, Wang, Hui   +6 more
core   +1 more source

C5aR1 antagonism alters microglial polarization and mitigates disease progression in a mouse model of Alzheimer’s disease

Acta Neuropathologica Communications, 2022
Multiple studies have recognized the involvement of the complement cascade during Alzheimer’s disease pathogenesis. However, the specific role of C5a-C5aR1 signaling in the progression of this neurodegenerative disease is still not clear.
Angela Gomez-Arboledas, Klebea Carvalho, Gabriela Balderrama-Gutierrez, Shu-Hui Chu, Heidi Yahan Liang, Nicole D. Schartz, Purnika Selvan, Tiffany J. Petrisko, Miranda A. Pan, Ali Mortazavi, Andrea J. Tenner   +10 more
doaj   +1 more source