Results 131 to 140 of about 7,153 (219)

C5aR1+ macrophages are involved in the progression of endometriosis

Reproductive and Developmental Medicine
Objective: Immune dysfunction plays an important role in the pathogenesis of endometriosis. C5a, a by-product of complement activation, binds to its receptor (C5a receptor 1, C5aR1) in various cells, including macrophages. The combination of C5a and C5aR1 in macrophages induces M2 polarization. There is no consistent conclusion
Xi Chen, Wei-Wen Zuo, Guo-Dong Zhang, Cong-Jian Xu   +3 more
openaire   +1 more source

A molecular roadmap of the AGM region reveals BMP ER as a novel regulator of HSC maturation [PDF]

, 2017
In the developing embryo, hematopoietic stem cells (HSCs) emerge from the aorta-gonad-mesonephros (AGM) region, but the molecular regulation of this process is poorly understood.
Alexander Medvinsky, Alison C. McGarvey, Anders, Benjamini, Blank, Boisset, Bowie, Burns, Charbord, Chen, Chhabra, Ciau-Uitz, Ciau-Uitz, Coffinier, Conley, Crisan, Croft, Cumano, Céline Souilhol, David Hills, David Rice, de Bruijn, de Bruijn, Ding, Duncan Godwin, Durand, Dyer, Edgar, Espín-Palazón, Fabregat, Gama-Norton, Gering, Gering, González-Murillo, Guiu, Hadland, Halbritter, Heinke, Heinke, Helbing, Helbing, Huang, Jaffredo, Kabrun, Kamimura, Kanehisa, Kelley, Kemp, Kim, Kobayashi, Kumaravelu, Kunisaki, Langmead, Lara-Astiaso, Law, Leinonen, Leung, Levéen, Li, Li, Lizama, Love, Lugus, Lund, Magnúsdóttir, Marshall, Mascarenhas, McKinney-Freeman, Medvinsky, Medvinsky, Medvinsky, Molyneaux, Monteiro, Moreno-Miralles, Moser, Moser, Müller, Nakano, Nimmo, Nishimura, North, North, Nostro, Peeters, Pereira, Pina, Pouget, Rentzsch, Richardson, Ritchie, Ritva Rice, Robin, Robinson, Ruiz-Herguido, Rybtsov, Rybtsov, Rybtsov, Sara Tamagno, Sawamiphak, Schaefer, Serpe, Simon R. Tomlinson, Solaimani Kartalaei, Soriano, Souilhol, Souilhol, Stanislav Rybtsov, Sturgeon, Subramanian, Swiers, Tagliabracci, Taoudi, Taoudi, Taoudi, Tober, Trompouki, Umulis, Wilkerson, Wilkinson, Wu, Yates, Yoder, Yokomizo, Yvernogeau, Zhou, Zovein   +125 more
core   +2 more sources

Macrophage centripetal migration drives spontaneous healing process after spinal cord injury. [PDF]

, 2019
Traumatic spinal cord injury (SCI) brings numerous inflammatory cells, including macrophages, from the circulating blood to lesions, but pathophysiological impact resulting from spatiotemporal dynamics of macrophages is unknown.
Edgerton, V Reggie, Hara, Masamitsu, Harimaya, Katsumi, Inoue, Kazuhide, Iwamoto, Yukihide, Kijima, Ken, Kobayakawa, Kazu, Kubota, Kensuke, Masuda, Takahiro, Matsumoto, Yoshihiro, Nakashima, Yasuharu, Ohkawa, Yasuyuki, Okada, Seiji, Ozato, Keiko, Saito, Takeyuki, Tamaru, Tetsuya, Tamura, Tomohiko, Tsuda, Makoto, Yokota, Kazuya, Yoshizaki, Shingo   +19 more
core   +1 more source

Epithelial C5aR1 Signaling Enhances Uropathogenic Escherichia coli Adhesion to Human Renal Tubular Epithelial Cells

Frontiers in Immunology, 2018
Recent work in a murine model of ascending urinary tract infection has suggested that C5a/C5aR1 interactions play a pathogenic role in the development of renal infection through enhancement of bacterial adhesion/colonization to renal tubular epithelial ...
Yun Song, Kun-Yi Wu, Weiju Wu, Zhao-Yang Duan, Ya-Feng Gao, Liang-Dong Zhang, Tie Chong, Malgorzata A. Garstka, Wuding Zhou, Ke Li   +9 more
doaj   +1 more source

Concepts of GPCR-controlled navigation in the immune system

, 2019
G-protein-coupled receptor (GPCR) signaling is essential for the spatiotemporal control of leukocyte dynamics during immune responses. For efficient navigation through mammalian tissues, most leukocyte types express more than one GPCR on their surface ...
Boneschansker L, Brandt SL, Chan EC, Filippo K, Freedman NJ, Hjorto GM, Hons M, Katakai T, Kitayama J, Lemos C, Ley K, Miyabe Y, Moussavi‐Harami SF, Proudfoot AEI, Purvanov V, Rot A, Scheiermann C, Schwarz J, Sokol CL, Sotsios Y, Steury MD, Takeda A, Thiriot A, Tomhave ED, Wang Y, Yanagihara S, Zhang Y   +26 more
core   +1 more source

Silenced-C5ar1 improved multiple organ injury in sepsis rats via inhibiting neutrophil extracellular trap

Journal of Molecular Histology
Sepsis has a systemic inflammatory response syndrome caused by infection. While neutrophils play contradictory roles in different stages of sepsis. Neutrophils have been proven to play an antibacterial role by producing neutrophil extracellular traps ...
Bin Shen, Qikai Shen, Qingqiu Zeng, Lingyan Zhang, Xiaofeng Li   +4 more
semanticscholar   +1 more source

Abstracts

Cancer Science, Volume 117, Issue S1, Page 1-2148, January 2026.
wiley   +1 more source

C5a Regulates IL-1β Production and Leukocyte Recruitment in a Murine Model of Monosodium Urate Crystal-Induced Peritonitis [PDF]

, 2017
Adrian W. S. Ho, Alessandra Mortellaro, Baalasubramanian Sivasankar, Federica Laudisi, Gim Gee Teng, Hanif J. Khameneh, Heidi Derks, Matheswaran Kandasamy   +7 more
core   +1 more source

Structural and Functional Effects of C5aR1 Antagonism in a Rat Model of Neonatal Hypoxic-Ischemic Encephalopathy

Developmental Neuroscience
Introduction: The complement response activates upon reperfusion in neonatal hypoxic-ischemic encephalopathy (HIE) and contributes to excessive neuroinflammation and worse outcomes.
Angela Saadat, Haree K. Pallera, Frank A. Lattanzio, Dale A. Owens, Amy Gaines, Sai Susmitha Ravi, Tushar Shah   +6 more
semanticscholar   +1 more source

Complement component 5a receptor 1 (C5AR1; C5AR) [PDF]

Science-Business eXchange, 2014
openaire   +1 more source