Results 1 to 10 of about 305,587 (238)

Interplay of Eph-Ephrin Signalling and Cadherin Function in Cell Segregation and Boundary Formation

Frontiers in Cell and Developmental Biology, 2021
The segregation of distinct cell populations to form sharp boundaries is crucial for stabilising tissue organisation, for example during hindbrain segmentation in craniofacial development.
David G. Wilkinson
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Molecular Characterization of Differentiated-Resistance MSC Subclones by Single-Cell Transcriptomes

Frontiers in Cell and Developmental Biology, 2022
Background: The mechanism of tumorigenicity potentially evolved in mesenchymal stem cells (MSCs) remains elusive, resulting in inconsistent clinical application efficacy.
Andres Stucky, Li Gao, Shengwen Calvin Li, Shengwen Calvin Li, Lingli Tu, Lingli Tu, Jun Luo, Xi Huang, Xuelian Chen, Xiaoqing Li, Tiffany H. Park, Jin Cai, Mustafa H. Kabeer, Ashley S. Plant, Lan Sun, Xi Zhang, Jiang F. Zhong   +16 more
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Mutation in the Cadherin Gene Is a Key Factor for Pink Bollworm Resistance to Bt Cotton in China

Toxins, 2022
Transgenic crops producing Bacillus thuringiensis (Bt) toxins are widely planted for insect control, but their efficacy may decrease as insects evolve resistance.
Ling Wang, Dong Xu, Yunxin Huang, Huazhong Zhou, Weiguo Liu, Shengbo Cong, Jintao Wang, Wenjing Li, Peng Wan   +8 more
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Transcriptional Analysis of Cotton Bollworm Strains with Different Genetic Mechanisms of Resistance and Their Response to Bacillus thuringiensis Cry1Ac Toxin

Toxins, 2022
Transgenic crops producing Bacillus thuringiensis (Bt) insecticidal proteins are grown widely for pest control, but the evolution of resistance in target pests could reduce their efficacy.
Shan Yu, Chenyang Wang, Kaixia Li, Yihua Yang, Ya-Zhou He, Yidong Wu   +5 more
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Celsr1 adhesive interactions mediate the asymmetric organization of planar polarity complexes

eLife, 2021
To orchestrate collective polarization across tissues, planar cell polarity (PCP) proteins localize asymmetrically to cell junctions, a conserved feature of PCP that requires the atypical cadherin Celsr1. We report that mouse Celsr1 engages in both trans-
Sara N Stahley, Lena P Basta, Rishabh Sharan, Danelle Devenport   +3 more
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Deletion of Calsyntenin-3, an atypical cadherin, suppresses inhibitory synapses but increases excitatory parallel-fiber synapses in cerebellum

eLife, 2022
Cadherins contribute to the organization of nearly all tissues, but the functions of several evolutionarily conserved cadherins, including those of calsyntenins, remain enigmatic.
Zhihui Liu, Man Jiang, Kif Liakath-Ali, Alessandra Sclip, Jaewon Ko, Roger Shen Zhang, Thomas C Südhof   +6 more
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Mutations in a Novel Cadherin Gene Associated with Bt Resistance in Helicoverpa zea

G3: Genes, Genomes, Genetics, 2020
Transgenic corn and cotton produce crystalline (Cry) proteins derived from the soil bacterium Bacillus thuringiensis (Bt) that are toxic to lepidopteran larvae. Helicoverpa zea, a key pest of corn and cotton in the U.S., has evolved widespread resistance
Megan L. Fritz, Schyler O. Nunziata, Rong Guo, Bruce E. Tabashnik, Yves Carrière   +4 more
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MYPT1 inhibits the metastasis of renal clear cell carcinoma via the MAPK8/N‐cadherin pathway

FEBS Open Bio, 2022
Myosin phosphatase target subunit 1 (MYPT1) is a subunit of myosin phosphatase that is capable of regulating smooth muscle contraction. MYPT1 has been reported to be involved in a wide variety of tumours, but its expression and biological functions in ...
Qingling Xie, Ren Liu, Zhihao Zou, Yuanfa Feng, Yiqiao Huang, Guibin Xu, Wei Sun, Yuxiang Liang, Weide Zhong   +8 more
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Regulation of α-catenin conformation at cadherin adhesions

Journal of Biomechanical Science and Engineering, 2018
Cells in our body utilize a variety of adaptor proteins for transmitting context specific signals that arise from the cellular microenvironment. Adaptor proteins lack enzymatic activity and typically perform their function by acting as scaffolds that ...
Kabir H BISWAS
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Dynamics of the Actin Cytoskeleton at Adhesion Complexes

Biology, 2021
The shape of cells is altered to allow cells to adapt to their changing environments, including responding to internally generated and externally applied force. Force is sensed by cell surface adhesion proteins that are enriched in sites where cells bind
Nicholas M. Cronin, Kris A. DeMali
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