Results 91 to 100 of about 65,722 (350)

Gold Nanoclusters as Dual Agents for Engineering Tumor Vascular Leakiness and Performing Photothermal Therapy

Advanced Functional Materials, EarlyView.
Many cancer nanotherapeutics, while potent, suffer from the inability to escape from the tumor vasculature, especially in the absence of endothelial permeability. In this work, ultrasmall gold nanoclusters could engineer nanomaterials induced endothelial leakiness (NanoEL) and harness strong NIR induced photothermal characteristics to suppress tumor ...
Nengyi Ni, Kuoran Xing, Bihan Zhang, Baoteng Wang, Yinglu Chen, Jianping Xie, Xiao Sun, Jinping Wang, David Tai Leong   +8 more
wiley   +1 more source

Ladarixin, a dual CXCR1/2 inhibitor, attenuates experimental melanomas harboring different molecular defects by affecting malignant cells and tumor microenvironment. [PDF]

, 2017
CXCR1 and CXCR2 chemokine receptors and their ligands (CXCL1/2/3/7/8) play an important role in tumor progression. Tested to date CXCR1/2 antagonists and chemokine-targeted antibodies were reported to affect malignant cells in vitro and in animal models.
Alexeev, Vitali, Allegretti, Marcello, De Pizzol, Maria, Igoucheva, Olga, Jonas, Rebecca, Kemp, Daria Marley, Larijani, Mary, Lash, Elizabeth, Pidich, Alyson, Sato, Takami, Terai, Mizue   +10 more
core   +2 more sources

MagPiezo: A Magnetogenetic Platform for Remote Activation of Endogenous Piezo1 Channels in Endothelial Cells

Advanced Functional Materials, EarlyView.
MagPiezo enables wireless activation of endogenous Piezo1 channels without genetic modification using 19 nm magnetic nanoparticles and low‐intensity magnetic fields. It generates torque forces at the piconewton scale to trigger mechanotransduction in endothelial cells, standing as a novel platform to interrogate and manipulate Piezo1 activity in vitro.
Susel Del Sol‐Fernández, Mariarosaria De Simone, Yilian Fernández‐Afonso, Daniel Garcia‐Gonzalez, Pablo Martínez‐Vicente, Thomas van Zanten, Raluca M. Fratila, Maria Moros   +7 more
wiley   +1 more source

Models for pattern formation in somitogenesis: a marriage of cellular and molecular biology [PDF]

, 2002
Somitogenesis, the process by which a bilaterally symmetric pattern of cell aggregations is laid down in a cranio-caudal sequence in early vertebrate development, provides an excellent model study for the coupling of interactions at the molecular and ...
Gavaghan, D. J., Houston, P., Maini, P. K., McInerney, D., Schnell, S.   +4 more
core   +2 more sources

Generation of an Induced Pluripotent Stem Cell‐Derived Alveolar Type II In Vitro Model to Study Influenza A Virus Infection and Drug Treatments

Advanced Healthcare Materials, EarlyView.
Patient‐specific induced pluripotent stem cells (iPSCs) can be differentiated into alveolar type II cells (iAT2s), expanded as 3D alveolospheres, and grown at physiologically relevant air–liquid interface (ALI). This study shows for the first time the infectability of iAT2s by the influenza A virus (IAV) and proves their responsiveness to the well ...
Lena Gauthier, Hristina Koceva, Yann Bachelot, Rosanne W. Koutstaal, Puck B. van Kasteren, Marc Thilo Figge, Christian Eggeling, Alexander Sandy Mosig   +7 more
wiley   +1 more source

Comparative study of E-cadherin expression between reticular, erosive oral lichen planus and lichenoid lesions

Dental Research Journal
Background: Accurate and early diagnosis of dysplastic lesions is crucial for successful treatment. A decrease in E-cadherin expression has been observed in dysplastic lesions and tumors. Therefore, the aim of this study was to investigate the expression
Laleh Maleki, Gholamreza Jahanshahi, Forooz Keshani, Samira Fotoohi Ashiin   +3 more
doaj   +1 more source

Calcium-dependent dynamics of cadherin interactions at cell–cell junctions [PDF]

, 2011
Cadherins play a key role in the dynamics of cell–cell contact formation and remodeling of junctions and tissues. Cadherin–cadherin interactions are gated by extracellular Ca^(2+), which serves to rigidify the cadherin extracellular domains and promote ...
Al-Amoudi, Alattia, Alattia, Baumgartner, Benninger, C.-Y. Tai, Cleemann, Drees, E. A. Mosser, E. M. Schuman, Egelman, Gumbiner, Harrison, Harrison, He, Kitagawa, L.-P. Mok, Nagafuchi, Nagai, Nagar, Nicholson, Orm , Overduin, Pertz, Pokutta, Pumain, Rizzo, Rizzo, Rothen-Rutishauser, S. A. Kim, Shapiro, Sheridan, Sivasankar, Troyanovsky, Valentin, Wiest   +35 more
core   +2 more sources

A Human Neural Tube Model Using 4D Self‐Folding Smart Scaffolds

Advanced Healthcare Materials, EarlyView.
Induced pluripotent stem cells (iPSCs) exhibit features comparable to the inner cell mass of the human embryo. iPSCs are applied to a novel self‐folding 4D‐Neural Tube (4D‐NT) structure that mimics the neurulation process. This 4D‐NT model recapitulates early events of human neural development and represents a platform to explore neurodevelopmental ...
Claudia Dell'Amico, Irene Chiesa, Angela Toffano, Alessio Esposito, Piera Mancini, Chiara Magliaro, Angeliki Louvi, Carmelo De Maria, Marco Onorati   +8 more
wiley   +1 more source

Evaluation of CDH1;RUNX3 Expression in Cancerous and Normal Tissue of Patients With Gastric Cancer

پزشکی بالینی ابن سینا, 2017
Introduction: Gastric cancer is a multifactorial disease and the fourth most common cancer in the world and the second cause of death from cancer. This study was designed and performed to investigate CDH1 and RUNX3 genes expression in healthy and tumor ...
M Einolghozati, MH Sanati, H Efftpanah, N Shabab, M Saidijam   +4 more
doaj  

Mechanical Stress Inference for Two Dimensional Cell Arrays [PDF]

, 2011
Many morphogenetic processes involve mechanical rearrangement of epithelial tissues that is driven by precisely regulated cytoskeletal forces and cell adhesion.
A Puliafito, AC Martin, AC Martin, AJ Engler, BI Shraiman, Boris I. Shraiman, C Bertet, D Choquet, D Weaire, DP Kiehart, E Evans, F Graner, F Meng, GW Brodland, J Folkman, J Käfer, J Stavans, JT Blankenship, Kevin K. Chiou, L He, L Hufnagel, L Wolpert, Lars Hufnagel, M Affolter, M Dembo, M Köppen, M Rauzi, M Wyart, MA Wozniak, O Hamant, R Farhadifar, R Goodyear, RA Foty, S Bao, S Gilbert, S Huang, S Huang, SJ Bray, SL Campbell, SM Hutson, Stanislav Shvartsman, T Hayashi, T Lecuit, V Mirabet   +43 more
core   +5 more sources