Discovery of Drug-like Inhibitors of the Human Caf1/CNOT7 poly(A)-Selective Nuclease Using Compound Screening [PDF]
BiomoleculesThe human Ccr4–Not complex is a central regulator of post-transcriptional gene regulation, impacting on translation and mRNA degradation. In mRNA degradation, Ccr4–Not participates in the shortening of the mRNA poly(A)-tail via two catalytic subunits ...
Ishwinder Kaur +3 more
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Discovery of Substituted 5-(2-Hydroxybenzoyl)-2-Pyridone Analogues as Inhibitors of the Human Caf1/CNOT7 Ribonuclease [PDF]
MoleculesThe Caf1/CNOT7 nuclease is a catalytic component of the Ccr4-Not deadenylase complex, which is a key regulator of post-transcriptional gene regulation. In addition to providing catalytic activity, Caf1/CNOT7 and its paralogue Caf1/CNOT8 also contribute a
Ishwinder Kaur +3 more
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X-linked RBBP7 mutation causes maturation arrest and testicular tumors [PDF]
The Journal of Clinical Investigation, 2023 Maturation arrest (MA) is a subtype of non-obstructive azoospermia, and male infertility is a known risk factor for testicular tumors. However, the genetic basis for many affected individuals remains unknown.
Jingping Li +7 more
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Development and evaluation of a triplex real-time PCR assay for enhanced plague diagnostics in Madagascar. [PDF]
PLoS Neglected Tropical DiseasesBackgroundThe plague, caused by Yersinia pestis, remains a critical public health issue, particularly in endemic regions like Madagascar. Rapid and accurate detection of this pathogen is essential for effective outbreak management and timely intervention.
Beza Ramasindrazana +12 more
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Caffeine improves the shooting performance and reaction time of first-person shooter esports players: a dose-response study [PDF]
Frontiers in Sports and Active LivingCaffeine is recognized as one of the most effective dietary ergogenic aids in sports, yet its evidence-based effectiveness in esports is unclear. This study investigated the effects of two different doses of caffeine on the shooting performance and ...
Ethan J. Rogers +5 more
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Yersinia pestis Caf1 Protein: Effect of Sequence Polymorphism on Intrinsic Disorder Propensity, Serological Cross-Reactivity and Cross-Protectivity of Isoforms. [PDF]
PLoS ONE, 2016 Yersinia pestis Caf1 is a multifunctional protein responsible for antiphagocytic activity and is a key protective antigen. It is generally conserved between globally distributed Y. pestis strains, but Y. pestis subsp.
Pavel Kh Kopylov +9 more
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Caf1 regulates the histone methyltransferase activity of Ash1 by sensing unmodified histone H3
Epigenetics & Chromatin, 2023 Histone modifications are one of the many key mechanisms that regulate gene expression. Ash1 is a histone H3K36 methyltransferase and is involved in gene activation. Ash1 forms a large complex with Mrg15 and Caf1/p55/Nurf55/RbAp48 (AMC complex). The Ash1
Eojin Yoon, Ji-Joon Song
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Histone H3K56 acetylation, CAF1, and Rtt106 coordinate nucleosome assembly and stability of advancing replication forks. [PDF]
PLoS Genetics, 2011 Chromatin assembly mutants accumulate recombinogenic DNA damage and are sensitive to genotoxic agents. Here we have analyzed why impairment of the H3K56 acetylation-dependent CAF1 and Rtt106 chromatin assembly pathways, which have redundant roles in H3 ...
Marta Clemente-Ruiz +2 more
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Developing and evaluation of orodispersible tablets containing caffeine [PDF]
Romanian Journal of Pharmaceutical Practice, 2021 Starting from the premise that a reduced number of active pharmaceutical ingredients (APIs) are used to treat hypotension, the aim of this study consisted of developing new formulations of caffeine-orodispersible tablets (CAFODTs).
Robert-Alexandru Vlad +7 more
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Direct Quantification of Protein Antigens in Subunit Plague and Rickettsial Vaccine Preparations
Проблемы особо опасных инфекций, 2023 The aim of the work was to put forward the methods for direct quantitative determination of the content of Yersinia pestis and Rickettsia raoultii protein antigens in preparations and various prototypes of subunit vaccines. Materials and methods.
P. Kh. Kopylov, S. V. Dentovskaya
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