1‐Hydroxy‐xanthine derivatives inhibit the human Caf1 nuclease and Caf1‐containing nuclease complexes via Mg2+‐dependent binding [PDF]
FEBS Open Bio, 2019 In eukaryotic cells, cytoplasmic mRNA is characterised by a 3′ poly(A) tail. The shortening and removal of poly(A) tails (deadenylation) by the Ccr4‐Not nuclease complex leads to reduced translational efficiency and RNA degradation.
Blessing Airhihen +4 more
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The CAF1-NOT complex of trypanosomes [PDF]
Frontiers in Genetics, 2014 In African trypanosomes, there is no control of transcription initiation by RNA polymerase II at the level of individual protein-coding genes. Transcription is polycistronic, and individual mRNAs are excised by trans splicing and polyadenylation.
Esteban eErben +2 more
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Subunits of the Histone Chaperone CAF1 Also Mediate Assembly of Protamine-Based Chromatin
Cell Reports, 2013 One of the most dramatic forms of chromatin reorganization occurs during spermatogenesis, when the paternal genome is repackaged from a nucleosomal to a protamine-based structure. We assessed the role of the canonical histone chaperone CAF1 in Drosophila
Cécile M. Doyen +7 more
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Histone Loaders CAF1 and HIRA Restrict Epstein-Barr Virus B-Cell Lytic Reactivation
mBio, 2020 Epstein-Barr virus (EBV) infects 95% of adults worldwide and causes infectious mononucleosis. EBV is associated with endemic Burkitt lymphoma, Hodgkin lymphoma, posttransplant lymphomas, nasopharyngeal and gastric carcinomas. In these cancers and in most
Yuchen Zhang +7 more
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CAF1-knockout mice are more susceptive to lipopolysaccharide-induced acute lung injury
Journal of Inflammation Research, 2016 Jia-Xin Shi,1 Jia-Shu Li,1 Rong Hu,1 Xiao-Min Li,2 Hong Wang3 1Department of Respiratory Medicine, Lianyungang First People’s Hospital, Affiliated Hospital of Xuzhou Medical University, Affiliated Hospital of the Clinical Medical School of Nanjing ...
Shi JX, Li JS, Hu R, Li XM, Wang H
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BTG2 bridges PABPC1 RNA-binding domains and CAF1 deadenylase to control cell proliferation [PDF]
Nature Communications, 2016 BTG2 promotes mRNA poly(A) tail shortening and regulates cellular differentiation. Here, Stupfler et al. show that the BTG2 APRO domain interacts with PABPC1 RRM1, allowing the former to recruit and stimulate the poly(A) tail shortening activity of CAF1 ...
Benjamin Stupfler +3 more
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DREF Genetically Counteracts Mi-2 and Caf1 to Regulate Adult Stem Cell Maintenance.
PLoS Genetics, 2019 Active adult stem cells maintain a bipotential state with progeny able to either self-renew or initiate differentiation depending on extrinsic signals from the surrounding microenvironment.
Benjamin Angulo +5 more
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Crystal structure and functional properties of the human CCR4-CAF1 deadenylase complex [PDF]
Nucleic Acids Research, 2021 Abstract The CCR4 and CAF1 deadenylases physically interact to form the CCR4-CAF1 complex and function as the catalytic core of the larger CCR4-NOT complex. Together, they are responsible for the eventual removal of the 3′-poly(A) tail from essentially all cellular mRNAs and consequently play a central role in the posttranscriptional ...
Ying Chen +3 more
openaire +3 more sources
Novel Bivalent mRNA-LNP Vaccine for Highly Effective Protection against Pneumonic Plague. [PDF]
Adv Sci (Weinh)The study investigates mRNA‐lipid nanoparticle vaccines targeting Yersinia pestis, the causative agent of plague. Combined F1+LcrV mRNA vaccination elicited robust immune responses and protected mice against virulent wild‐type and atypical strains.
Elia U +12 more
europepmc +2 more sources
The polymer and materials science of the bacterial fimbriae Caf1.
Biomater Sci, 2023 Progress in revealing the rich polymer and materials science of Capsular antigen fragment 1 (Caf1), a bacterial fimbriae expressed by the bacterium Yersina pestis, is described.
Fulton DA, Dura G, Peters DT.
europepmc +3 more sources