Results 21 to 30 of about 3,141 (147)

Caf1A usher possesses a Caf1 subunit-like domain that is crucial for Caf1 fibre secretion [PDF]

Biochemical Journal, 2009
The chaperone/usher pathway controls assembly of fibres of adhesive organelles of Gram-negative bacteria. The final steps of fibre assembly and fibre translocation to the cell surface are co-ordinated by the outer membrane proteins, ushers. Ushers consist of several soluble periplasmic domains and a single transmembrane β-barrel.
Xiaodi, Yu, Ganeshram R, Visweswaran, Zoe, Duck, Srisailam, Marupakula, Sheila, MacIntyre, Stefan D, Knight, Anton V, Zavialov   +6 more
openaire   +2 more sources

CCR4-Associated Factor CAF1 Is an Essential Factor for Spermatogenesis [PDF]

Molecular and Cellular Biology, 2004
The CCR4-associated protein CAF1 has been demonstrated to play several roles in the control of transcription and of mRNA decay. To gain further insight into its physiological function, we generated CAF1-deficient mice. They are viable, healthy, and normal in appearance; however, mCAF1(-/-) male mice are sterile.
Rouault, Jean-Pierre, Berthet, Cyril, Morera, Anne-Marie, Asensio, Marie-Jeanne, Chauvin, Marie-Agnès, Morel, Anne-Pierre, Dijoud, Frédérique, Magaud, Jean-Pierre, Durand, Philippe   +8 more
openaire   +4 more sources

Investigating the function of CAF1 deadenylases during plant stress responses [PDF]

Plant Signaling & Behavior, 2010
Alteration of gene expression plays a central role in the transmission of developmental and environmental signals. The steady-state transcript level within a cell is determined by the combination of the rate synthesis and the rate of degradation. While altering the rate of mRNA turnover is known to provide a rapid mechanism to reprogram transcript ...
Justin W, Walley, Dior R, Kelley, Tatyan, Savchenko, Katayoon, Dehesh   +3 more
openaire   +2 more sources

Single-cell multi-omics characterize colorectal tumors, adjacent healthy tissue and matched (tumor) organoids identifying CRC-unique features. [PDF]

Int J Cancer
What's New? Patient‐derived organoids provide a promising platform for modeling colorectal cancer. The authors demonstrated that organoids derived from normal colorectal tissue recapitulate the cellular composition and differentiation trajectory of colorectal crypts.
Yu Z, Derksen M, Te Pas BM, Ladstätter S, Overmeer R, Brazda P, van de Wetering M, Pourfarzad F, Vries RGJ, Megchelenbrink W, Bock C, Altucci L, Stunnenberg HG.   +12 more
europepmc   +2 more sources

An Unconventional Human Ccr4-Caf1 Deadenylase Complex in Nuclear Cajal Bodies [PDF]

Molecular and Cellular Biology, 2007
mRNA deadenylation is a key process in the regulation of translation and mRNA turnover. In Saccharomyces cerevisiae, deadenylation is primarily carried out by the Ccr4p and Caf1p/Pop2p subunits of the Ccr4-Not complex, which is conserved in eukaryotes including humans.
Eileen, Wagner, Sandra L, Clement, Jens, Lykke-Andersen   +2 more
openaire   +2 more sources

Insight into Interface Engineering at TiO₂/Dye through Molecularly Functionalized Caf1 Biopolymer [PDF]

ACS Sustainable Chemistry & Engineering, 2017
The fast charge recombination kinetics and poor sensitizing ability in dye-sensitized solar cells (DSSCs) result in a significant electron loss and performance degradation. However, the retarding of electron recombination and/or increasing light-harvesting efficiency (LHE) via employing an appropriate interface modifier in DSSCs has rarely been ...
Seckin Akin, Yakup Ulusu, Helen Waller, Jeremy H. Lakey, Savas Sonmezoglu   +4 more
openaire   +4 more sources

Halofuginone Disrupted Collagen Deposition via mTOR-eIF2α-ATF4 Axis to Enhance Chemosensitivity in Ovarian Cancer. [PDF]

Adv Sci (Weinh)
COL1A1, a major component of ECM, contributes to chemoresistance and poor prognosis in ovarian cancer. Halofuginone (HF) attenuates CAF‐secreted COL1A1 through mTOR‐eIF2α‐ATF4 axis. Notably, HF disrupts collagen deposition to form the looser ECM and facilitates CD8+ T cell infiltration, partially via M2‐M1 macrophage polarization to enhance ...
Li W, Wu Y, Zhang Y, Gao W, Li X, Luo H, Lu M, Liu Z, Luo A.   +8 more
europepmc   +2 more sources

Caf1 regulates translocation of ribonucleotide reductase by releasing nucleoplasmic Spd1-Suc22 assembly [PDF]

Nucleic Acids Research, 2007
Appropriate supply of deoxyribonucleotides by the ribonucleotide reductase (RNR) complex is essential for DNA replication and repair. One recent model for the RNR activation in Schizosaccharomyces pombe is translocation of the regulatory subunit Suc22 from the nucleoplasm to the cytoplasm.
Takahashi, Shinya, Kontani, Kenji, Araki, Yasuhiro, Katada, Toshiaki   +3 more
openaire   +2 more sources

Insights into the molecular architecture and histone H3-H4 deposition mechanism of yeast Chromatin assembly factor 1

eLife, 2017
How the very first step in nucleosome assembly, deposition of histone H3-H4 as tetramers or dimers on DNA, is accomplished remains largely unclear. Here, we report that yeast chromatin assembly factor 1 (CAF1), a conserved histone chaperone complex that ...
Paul Victor Sauer, Jennifer Timm, Danni Liu, David Sitbon, Elisabetta Boeri-Erba, Christophe Velours, Norbert Mücke, Jörg Langowski, Françoise Ochsenbein, Geneviève Almouzni, Daniel Panne   +10 more
doaj   +1 more source

Genome-Wide and Comprehensive Analysis of the Multiple Stress-Related CAF1 (CCR4-Associated Factor 1) Family and Its Expression in Poplar

Plants, 2021
Poplar is one of the most widely used tree in afforestation projects. However, it is susceptible to abiotic and biotic stress. CCR4-associated factor 1 (CAF1) is a major member of CCR4-NOT, and it is mainly involved in transcriptional regulation and mRNA
Pu Wang, Lingling Li, Hui Wei, Weibo Sun, Peijun Zhou, Sheng Zhu, Dawei Li, Qiang Zhuge   +7 more
doaj   +1 more source