Results 61 to 70 of about 3,141 (147)
Regulation of eukaryotic mRNA deadenylation and degradation by the Ccr4-Not complex
Frontiers in Cell and Developmental Biology, 2023 Accurate and precise regulation of gene expression programmes in eukaryotes involves the coordinated control of transcription, mRNA stability and translation.
Lorenzo Pavanello +2 more
doaj +1 more source
Environmental Microbiology, Volume 28, Issue 2, February 2026.We investigated the survival of the yeast Rhodotorula frigidalcoholis and analysed its RNA after exposure to icy moon conditions. Our results show how the yeast can tolerate the extreme conditions and performs metabolic functions under the exposure conditions; for example, by halting the cell cycle in order to repair. Created in BioRender.
Tommaso Zaccaria +5 more
wiley +1 more source
Cell Proliferation, Volume 59, Issue 1, January 2026.Mutations in the RING finger domain (C3HC4) of RNF219 promote the formation of RNF219 condensates, which are able to encapsulate the CCR4‐NOT complex. These RNF219Mut‐CCR4‐NOT condensates reduce the deacetylation activity of the CCR4‐NOT complex and induce cell proliferation.
Chen Chen +4 more
wiley +1 more source
Research in Molecular Medicine, 2018 Background: Yersinia pestis and Francisella tularensis cause plague and tularemia, which are known as diseases of the newborn and elderly, respectively.
Nafiseh Pourmahdi +3 more
doaj +1 more source
Biology Open, 2019 Cell-fate maintenance is important to preserve the variety of cell types that are essential for the formation and function of tissues. We previously showed that the acetylated histone-binding protein BET-1 maintains cell fate by recruiting the histone ...
Yukimasa Shibata +2 more
doaj +1 more source
Síntese e caracterização de inibidores da deadenilase CAF1 (CNOT7) humana
Revista dos Trabalhos de Iniciação Científica da UNICAMP, 2018 A proteína CAF1 desempenha função importante no controle da expressão gênica, pois participa do processo de deadenilação da cauda poli(A) de RNA mensageiros (mRNAs), contribuindo assim para a degradação das moléculas de mRNAs. Estudos recentes mostraram uma correlação entre a atividade da proteína CAF1 humana (hCAF1) e a progressão de alguns tumores ...
Silvana A. Rocco +4 more
openaire +2 more sources
BioMed Research International, Volume 2026, Issue 1, 2026.Colorectal cancer (CRC) is highly metastatic, yet the interaction between tumor cells and microenvironment components remains unclear, as does its impact on patient outcomes. Single‐cell data (GSE225857 and GSE166555) were collected for transformed and primary CRC to identify differing cell types and their subpopulations. Prognostic signature genes for
Yiqing Tan +9 more
wiley +1 more source
The biological function of the WD40 repeat‐containing protein p55/Caf1 in Drosophila [PDF]
Developmental Dynamics, 2012 AbstractBackground: The p55 family WD40 repeat‐containing histone chaperone proteins are components of several chromatin regulatory complexes (such as PRC2, NURF and CAF‐1) and interact with histone H4, yet their functional relevance in vivo is unclear.
Pei, Wen, Zhenghui, Quan, Rongwen, Xi
openaire +2 more sources
Transcription and FACT facilitate the restoration of replication-coupled chromatin assembly defects
Scientific Reports, 2023 Genome duplication occurs through the coordinated action of DNA replication and nucleosome assembly at replication forks. Defective nucleosome assembly causes DNA lesions by fork breakage that need to be repaired.
Marta Barrientos-Moreno +6 more
doaj +1 more source
Xenopus CAF1 requires NOT1-mediated interaction with 4E-T to repress translation in vivo [PDF]
RNA, 2015 RNA-regulatory factors bound to 3′ UTRs control translation and stability. Repression often is associated with poly(A) removal. The deadenylase CAF1 is a core component of the CCR4–NOT complex. Our prior studies established that CAF1 represses translation independent of deadenylation.
Waghray, Shruti +3 more
openaire +2 more sources