Results 71 to 80 of about 3,141 (147)
MMS22L is a novel key actor of normal and pathological erythropoiesis
HemaSphere, Volume 9, Issue 12, December 2025.Abstract The emergence of next‐generation sequencing techniques has led to the genetic characterization of numerous congenital erythroid disorders, emphasizing crucial pathways in both normal and pathological erythropoiesis. In this study, whole exome sequencing of a single patient with atypical congenital pure red cell aplasia revealed a mutation in ...
Elia Colin +31 more
wiley +1 more source
Stapled Peptides as Inhibitors of mRNA Deadenylation
Angewandte Chemie, Volume 137, Issue 1, January 2, 2025.A structure‐based design approach led to a stapled peptide that inhibits the deadenylation activity of the CCR4‐NOT complex. The stapled peptide exhibited excellent cell permeability and high binding affinity to the target protein. The peptide was able to stabilize RNA containing poly(A) tail by inhibiting the activity of the CCR4‐NOT complex both in ...
Sunit Pal +6 more
wiley +2 more sources
The HP1α–CAF1–SetDB1‐containing complex provides H3K9me1 for Suv39‐mediated K9me3 in pericentric heterochromatin [PDF]
EMBO reports, 2009 Trimethylation of lysine 9 in histone H3 (H3K9me3) enrichment is a characteristic of pericentric heterochromatin. The hypothesis of a stepwise mechanism to establish and maintain this mark during DNA replication suggests that newly synthesized histone H3 goes through an intermediate methylation state to become a substrate for the histone ...
Alejandra, Loyola +8 more
openaire +2 more sources
MedComm, Volume 6, Issue 11, November 2025.This review explores the multifaceted roles of cancer‐associated fibroblasts (CAFs) in tumor biology. It examines their diverse origins, dynamic activation via signaling pathways, and spatial–temporal heterogeneity, proposing an updated classification of eight distinct CAF subtypes. The review highlights CAFs' contributions to tumor growth, metastasis,
Chang Fan +4 more
wiley +1 more source
A role for Caf1 in mRNA deadenylation and decay in trypanosomes and human cells [PDF]
Nucleic Acids Research, 2008 The eukaryotic Ccr4/Caf1/Not complex is involved in deadenylation of mRNAs. The Caf1 and Ccr4 subunits both potentially have deadenylating enzyme activity. We investigate here the roles of Ccr4 and Caf1 in deadenylation in two organisms that separated early in eukaryotic evolution: humans and trypanosomes.
Schwede, Angela +5 more
openaire +2 more sources
Cell Proliferation, Volume 58, Issue 10, October 2025.RNF187 mediates the polyubiquitination and subsequent degradation of WDR77, reduces H4R3me2s catalysed by the WDR77/PRMT5 complex, and derepresses the transcription of EGR1, thereby promoting the proliferation and migration of human SSCs. ABSTRACT The E3 ubiquitin ligase RNF187, also known as RING domain AP1 coactivator‐1, is a member of the RING ...
Haoyue Hu +12 more
wiley +1 more source
RNA‐binding proteins orchestrating immunity in plants
The Plant Journal, Volume 123, Issue 5, September 2025.SUMMARY RNA‐binding proteins (RBPs) direct the function and fate of RNA throughout the RNA lifecycle and play important roles in plant immunity, orchestrating the post‐transcriptional reprogramming of the transcriptome following induction of plant immune responses, a process that we term ‘RBP‐mediated immunity’. Although the importance of specific RBPs
Marcel Bach‐Pages +4 more
wiley +1 more source
Regulation of chromatin accessibility by the histone chaperone CAF-1 sustains lineage fidelity
Nature Communications, 2022 Cell fate commitment involves transcription factor activity and changes in chromatin architecture. Here the authors show that CAF-1 maintains lineage fidelity by controlling chromatin accessibility at specific sites; suppressing CAF-1 triggers ...
Reuben Franklin +20 more
doaj +1 more source
Harnessing the Potential of mRNA Vaccines Against Infectious Diseases
Microbial Biotechnology, Volume 18, Issue 8, August 2025.RNA vaccines are promising because of their flexible design, strong immunogenicity, safety and rapid development. Recent advances have enabled mRNA vaccines to target various pathogens, including viruses such as influenza and HIV, bacteria such as Mycobacteria and Pseudomonas aeruginosa, and parasites such as those causing malaria.
Nouran Rezk, Siobhán McClean
wiley +1 more source
BMC Genomics, 2018 Background 337S is a novel bi-pole-photo-thermo-sensitive genic male sterile line in wheat, and sensitive to both long day length/high temperature and short day length/low temperature condition.
Longqing Sun +3 more
doaj +1 more source