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Non-ionotropic voltage-gated calcium channel signaling [PDF]
ChannelsVoltage-gated calcium channels (VGCCs) are the major conduits for calcium ions (Ca2+) within excitable cells. Recent studies have highlighted the non-ionotropic functionality of VGCCs, revealing their capacity to activate intracellular pathways ...
Michael Trus, Daphne Atlas
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Inhibition of Contractility of Isolated Caprine Detrusor by the Calcium Channel Blocker Cilnidipine and Reversal by Calcium Channel Openers [PDF]
Current Therapeutic Research, 2023 : Background: Cilnidipine is a fourth-generation calcium channel blocker that is clinically used to treat hypertension. It is a dihydropyridine that blocks L- and N-type calcium channels.
Steffi A. Maria, MD +4 more
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Frontiers in Cellular Neuroscience, 2023 How do neurons that implement cell-autonomous self-regulation of calcium react to knockout of individual ion-channel conductances? To address this question, we used a heterogeneous population of 78 conductance-based models of hippocampal pyramidal ...
Sunandha Srikanth +2 more
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Nature Communications, 2022 Ultrasonic neuromodulation has the unique potential to provide non-invasive control of neural activity in deep brain regions with high spatial precision and without chemical or genetic modification.
Sangjin Yoo +4 more
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CLCA2 is a positive regulator of store-operated calcium entry and TMEM16A. [PDF]
PLoS ONE, 2018 The Chloride Channel Accessory (CLCA) protein family was first characterized as regulators of calcium-activated chloride channel (CaCC) currents (ICaCC), but the mechanism has not been fully established. We hypothesized that CLCAs might regulate ICaCC by
Aarushi Sharma +4 more
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The role of calcium channel blockers in wound healing [PDF]
Iranian Journal of Basic Medical Sciences, 2018 Wound healing is a natural response to restore the injured tissue to normal. Wound healing is also complicated process involving different cellular, molecular and biochemical mechanisms and various types of cytokines and growth factors.
Hoda Mojiri-Forushani
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Channels, 2023 One of nature’s exceptions was discovered when a Cav3 T-type channel was observed to switch phenotype from a calcium channel into a sodium channel by neutralizing an aspartate residue in the high field strength (HFS) +1 position within the ion ...
J. David Spafford
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Renoprotective effect of calcium channel blockers [PDF]
Srpski Arhiv za Celokupno Lekarstvo, 2009 The advancing chronic renal failure is at most the consequence of secondary haemodynamic and metabolic factors as intraglomerular hypertension and glomerular hypertrophy.
Dimković Nada, Dimković Siniša
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Critical Care Explorations, 2021 OBJECTIVES:. The aim was to evaluate the effect of dihydropyridine calcium channel blocker on the prognosis for moderate-severe pulmonary acute respiratory distress syndrome in hypertension patients. DESIGN:.
Fengyuan Li, MD +9 more
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Pflügers Archiv - European Journal of Physiology, 2018 Tuned calcium entry through voltage-gated calcium channels is a key requirement for many cellular functions. This is ensured by channel gates which open during membrane depolarizations and seal the pore at rest. The gating process is determined by distinct sub-processes: movement of voltage-sensing domains (charged S4 segments) as well as opening and ...
Hering, S. +5 more
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