Results 1 to 10 of about 3,583,729 (430)
Energetics of discrete selectivity bands and mutation-induced transitions in the calcium-sodium ion channels family [PDF]
Phys. Rev. E 88, 052712 (2013), 2013 We use Brownian dynamics simulations to study the permeation properties of a generic electrostatic model of a biological ion channel as a function of the fixed charge $Q_f$ at its selectivity filter. We reconcile the recently-discovered discrete calcium conduction bands M0 ($Q_f$=1e), M1 (3e), M2 (5e) with the set of sodium conduction bands L0 (0.5-0 ...
Eisenberg, Robert S. +4 more
arxiv +5 more sources
Discrete stochastic modeling of calcium channel dynamics [PDF]
, 1999 We propose a simple discrete stochastic model for calcium dynamics in living cells. Specifically, the calcium concentration distribution is assumed to give rise to a set of probabilities for the opening/closing of channels which release calcium thereby changing those probabilities.
Baer, Markus +3 more
arxiv +3 more sources
Non-ionotropic voltage-gated calcium channel signaling [PDF]
ChannelsVoltage-gated calcium channels (VGCCs) are the major conduits for calcium ions (Ca2+) within excitable cells. Recent studies have highlighted the non-ionotropic functionality of VGCCs, revealing their capacity to activate intracellular pathways ...
Michael Trus, Daphne Atlas
doaj +2 more sources
Inhibition of Contractility of Isolated Caprine Detrusor by the Calcium Channel Blocker Cilnidipine and Reversal by Calcium Channel Openers [PDF]
Current Therapeutic Research, 2023 : Background: Cilnidipine is a fourth-generation calcium channel blocker that is clinically used to treat hypertension. It is a dihydropyridine that blocks L- and N-type calcium channels.
Steffi A. Maria, MD +4 more
doaj +2 more sources
eLife, 2014 TMEM16A forms calcium-activated chloride channels (CaCCs) that regulate physiological processes such as the secretions of airway epithelia and exocrine glands, the contraction of smooth muscles, and the excitability of neurons.
Jason Tien +6 more
doaj +2 more sources
Frontiers in Cellular Neuroscience, 2023 How do neurons that implement cell-autonomous self-regulation of calcium react to knockout of individual ion-channel conductances? To address this question, we used a heterogeneous population of 78 conductance-based models of hippocampal pyramidal ...
Sunandha Srikanth +2 more
doaj +1 more source
CLCA2 is a positive regulator of store-operated calcium entry and TMEM16A. [PDF]
PLoS ONE, 2018 The Chloride Channel Accessory (CLCA) protein family was first characterized as regulators of calcium-activated chloride channel (CaCC) currents (ICaCC), but the mechanism has not been fully established. We hypothesized that CLCAs might regulate ICaCC by
Aarushi Sharma +4 more
doaj +1 more source
The role of calcium channel blockers in wound healing [PDF]
Iranian Journal of Basic Medical Sciences, 2018 Wound healing is a natural response to restore the injured tissue to normal. Wound healing is also complicated process involving different cellular, molecular and biochemical mechanisms and various types of cytokines and growth factors.
Hoda Mojiri-Forushani
doaj +1 more source
Channels, 2023 One of nature’s exceptions was discovered when a Cav3 T-type channel was observed to switch phenotype from a calcium channel into a sodium channel by neutralizing an aspartate residue in the high field strength (HFS) +1 position within the ion ...
J. David Spafford
doaj +1 more source
Renoprotective effect of calcium channel blockers [PDF]
Srpski Arhiv za Celokupno Lekarstvo, 2009 The advancing chronic renal failure is at most the consequence of secondary haemodynamic and metabolic factors as intraglomerular hypertension and glomerular hypertrophy.
Dimković Nada, Dimković Siniša
doaj +1 more source