Results 91 to 100 of about 6,142,205 (404)

Ablation of LRP6 in alpha‐smooth muscle actin‐expressing cells abrogates lung inflammation and fibrosis upon bleomycin‐induced lung injury

FEBS Letters, EarlyView.
Low‐density lipoprotein receptor‐related protein 6 (LRP6) is a key receptor for the Wnt antagonist Dickkopf1 (DKK1). DKK1 protein expression is induced in a bleomycin (BLM)‐induced lung injury model. We show that DKK1 induces proinflammatory and profibrotic genes in lung fibroblasts.
Eun‐Ah Sung, Mikhail G. Dozmorov, SuJeong Song, Theingi Aung, Min Hee Park, Patricia J. Sime, Wook‐Jin Chae   +6 more
wiley   +1 more source

Astroglial calcium signaling displays short-term plasticity and adjusts synaptic efficacy

Frontiers in Cellular Neuroscience, 2015
Astrocytes are dynamic signaling brain elements able to sense neuronal inputs and to respond by complex calcium signals, which are thought to represent their excitability.
Jeremie eSibille, Jonathan eZapata, Jeremie eTeillon, Nathalie eRouach   +3 more
doaj   +1 more source

Evolutionary Covariant Positions within Calmodulin EF-hand Sequences Promote Ligand Binding [PDF]

, 2018
Intracellular calcium signaling is an essential regulatory mechanism through calcium-mediated signal transduction pathways involved in many cell processes, such as exocytosis, motility, apoptosis, excitability, transcription, and muscle contraction.
Vaidyanathan, Uma
core   +1 more source

Lysosomal calcium signaling regulates autophagy via calcineurin and TFEB

Nature Cell Biology, 2015
The view of the lysosome as the terminal end of cellular catabolic pathways has been challenged by recent studies showing a central role of this organelle in the control of cell function.
D. Medina, Simone Di Paola, I. Peluso, A. Armani, Diego De Stefani, Rossella Venditti, S. Montefusco, Anna Scotto-Rosato, Carolina Prezioso, A. Forrester, C. Settembre, Wuyang Wang, Qiong Gao, Haoxing Xu, M. Sandri, R. Rizzuto, M. D. De Matteis, A. Ballabio   +17 more
semanticscholar   +1 more source

The apo LETM1 F‐EF‐hand adopts a closed conformation that underlies a multi‐modal sensory role in mitochondria

FEBS Letters, EarlyView.
We present the first solution structure of the Ca2+‐depleted LETM1 F‐EF‐hand through a D676A/N678A Ca2+ binding‐deficient mutant, revealing a closed hydrophobic cleft caused by a unique F1‐helix pivot. The apo LETM1 F‐EF‐hand exhibits regiospecific hot and cold unfolding, sensitivity to physiological pH changes and potential for promiscuous heterotypic
Qi‐Tong Lin, Danielle M. Colussi, Peter B. Stathopulos   +2 more
wiley   +1 more source

Calcium Flux in Neutrophils Synchronizes β2 Integrin Adhesive and Signaling Events that Guide Inflammatory Recruitment [PDF]

, 2008
Intracellular calcium flux is an early step in the signaling cascade that bridges ligation of selectin and chemokine receptors to activation of adhesive and motile functions during recruitment on inflamed endothelium. Calcium flux was imaged in real time
A. Truneh, A. Truneh, B. L. Sabatini, C. E. Green, C. E. Green, C. Giagulli, C. Hellberg, C. Hellberg, C. J. Hauser, C. Laudanna, D. Eierman, D. J. Elzi, D. Tvorogov, Donald Griffin, E. J. Pettit, E. J. Pettit, E. J. Pettit, E. V. Davies, G. Cinamon, H. U. Zeilhofer, I. Ginis, Itsukyo Yamayoshi, J. A. DiVietro, J. L. Rodriguez-Fernandez, J. Richter, J. Soboloff, K. D. Forsyth, K. E. Kadash, K. Ley, L. Glasser, Lilian Kibathi, M. A. Lawson, M. L. Lupher Jr., M. P. Davies, M. Prakriya, M. Takami, O. Nusse, O. Nusse, R. Alon, R. Alon, R. Alon, R. J. Smith, R. Llinas, R. Llinas, R. Shamri, S. Feske, S. I. Simon, S. I. Simon, S. J. Hyduk, S. M. Simon, S. R. McMeekin, Scott I. Simon, Tiffany Tse, U. Y. Schaff, Ulrich Y. Schaff, W. Schorr   +55 more
core   +2 more sources

Synthesising Realistic Calcium Traces of Neuronal Populations Using GAN [PDF]

arXiv, 2020
Calcium imaging has become a powerful and popular technique to monitor the activity of large populations of neurons in vivo. However, for ethical considerations and despite recent technical developments, recordings are still constrained to a limited number of trials and animals.
arxiv  

Insertion of the FeB cofactor in cNORs lacking metal inserting chaperones

FEBS Letters, EarlyView.
Nitric oxide reductase is an enzyme found in the bacterial denitrification pathway. The NOR active site contains a non‐heme iron, often, but not always inserted with the assistance of chaperones. Here, we study the insertion of FeB in the subfamily of cNORs lacking chaperones and found a putative channel, conserved in the family, perhaps enabling the ...
Sofia Appelgren, Pia Ädelroth
wiley   +1 more source

Tetralol derivative NNC-55-0396 targets hypoxic cells in the glioblastoma microenvironment: an organ-on-chip approach

Cell Death and Disease
Glioblastoma (GBM) is a highly malignant brain tumour characterised by limited treatment options and poor prognosis. The tumour microenvironment, particularly the central hypoxic region of the tumour, is known to play a pivotal role in GBM progression ...
Clara Bayona, Lía Alza, Teodora Ranđelović, Marta C. Sallán, Anna Visa, Carles Cantí, Ignacio Ochoa, Sara Oliván, Judit Herreros   +8 more
doaj   +1 more source

Progesterone induces meiosis through two obligate co-receptors with PLA2 activity

eLife
The steroid hormone progesterone (P4) regulates multiple aspects of reproductive and metabolic physiology. Classical P4 signaling operates through nuclear receptors that regulate transcription. In addition, P4 signals through membrane P4 receptors (mPRs)
Nancy Nader, Lama Assaf, Lubna Zarif, Anna Halama, Sharan Yadav, Maya Dib, Nabeel Attarwala, Qiuying Chen, Karsten Suhre, Steven Gross, Khaled Machaca   +10 more
doaj   +1 more source