Results 101 to 110 of about 149 (148)
Identifying prognostic targets in metastatic prostate cancer beyond AR
FEBS Open Bio, EarlyView.Genome‐wide functional screens combined with a large gene expression database and clinical outcomes can identify new therapeutic vulnerabilities in prostate cancer. Eight potentially druggable targets demonstrated strong dependency in cell lines, were associated with worse prognosis clinically, and showed evidence of protein expression in prostate ...
Emily Feng +13 more
wiley +1 more source
Understanding and Overcoming Immunotherapy Resistance in Skin Cancer: Mechanisms and Strategies
Aging and Cancer, EarlyView.This narrative review explores the mechanisms driving immunotherapy resistance in skin cancer, including tumor microenvironment factors, genetic mutations, and immune evasion strategies. It highlights potential strategies to overcome resistance, offering insights for improving therapeutic outcomes and guiding future research in personalized ...
Shreya Singh Beniwal +8 more
wiley +1 more source
Multi‐institutional study on image quality for a novel CBCT solution on O‐ring linac
Journal of Applied Clinical Medical Physics, EarlyView.Abstract Introduction This work presents a multi‐institutional study on image quality provided by a novel cone beam computed tomography (CBCT). The main goal is to investigate the consistency of imaging performance across multiple institutions.
Luis Agulles‐Pedrós +11 more
wiley +1 more source
Journal of Applied Clinical Medical Physics, EarlyView.Abstract Purpose The Bravos v1.2 control software introduces a ring applicator component type (ACT) with channel length verification to address geometric characteristics and dosimetric discrepancies caused by source positioning inaccuracies. This study aims to commission the ring applicator and investigate the new ring ACT in Bravos 1.2.
Xiuxiu He +4 more
wiley +1 more source
Journal of Applied Clinical Medical Physics, EarlyView.Abstract Purpose This study evaluates the dosimetric and geometric precision of a virtual cone technique using CBCT‐based polymer gel dosimetry, enabling radiation delivery, and imaging readout within an identical spatial coordinate system. Methods We created a C# script for a virtual cone technique that generates a treatment plan with 10 gantry arcs ...
Tenzin Kunkyab +6 more
wiley +1 more source
Journal of Applied Clinical Medical Physics, EarlyView.Abstract Purpose Breast cancer is a neoplastic disease with high prevalence among women. Radiotherapy is one of the principal treatment modalities for this disease, but it poses significant challenges. This study aimed to compare and evaluate the technical and dosimetric performance of conventional C‐arm linac systems and a new design, Halcyon, in the ...
Mustafa Çağlar +8 more
wiley +1 more source
Journal of Applied Clinical Medical Physics, EarlyView.Abstract Purpose To assess the predictive capability of CT radiomics features for early recurrence (ER) of pancreatic ductal adenocarcinoma (PDAC). Methods Postoperative PDAC patients were retrospectively selected, all of whom had undergone preoperative CT imaging and surgery. Both patients with resectable or borderline‐resectable pancreatic cancer met
Xinze Du +7 more
wiley +1 more source
Log file‐based quality assurance method for respiratory gating system
Journal of Applied Clinical Medical Physics, EarlyView.Abstract Background As medical linear accelerator technology advances, enabling higher dose rate deliveries, hypofractionation regimens has increased. This necessitates respiratory gating systems that synchronize radiation delivery with tumor position, requiring simple rigorous quality assurance (QA) to ensure treatment accuracy and patient safety ...
Wonjoong Cheon +7 more
wiley +1 more source
Accounting for TLD response to CBCT protocols in external beam radiotherapy dose monitoring
Journal of Applied Clinical Medical Physics, EarlyView.Abstract Purpose LiF thermoluminescent dosimeters (TLDs) are commonly used in radiation therapy to verify the delivered dose. Examples include dose verification for complicated treatment setups or cardiovascular implantable electronic devices (CIEDs). TLDs may be present for both the pre‐treatment imaging kilovoltage (kV) beam and the megavoltage (MV ...
Andrew J. White +5 more
wiley +1 more source
Localization accuracy of 6‐second CBCT for lung IGRT with various breathing patterns
Journal of Applied Clinical Medical Physics, EarlyView.Abstract Purpose The 6‐second cone beam computed tomography (CBCT) acquisition of the Ethos HyperSight (Varian Medical Systems, Inc. Palo Alto, CA, USA) on‐board imaging system offers benefits, but could be too fast to accurately capture an average target position in a free‐breathing lung cancer patient. This study aimed to ascertain whether a 6‐second
Jihye Koo +5 more
wiley +1 more source