Noxious Iron–Calcium Connections in Neurodegeneration
Frontiers in Neuroscience, 2019 Iron and calcium share the common feature of being essential for normal neuronal function. Iron is required for mitochondrial function, synaptic plasticity, and the development of cognitive functions whereas cellular calcium signals mediate ...
Marco Tulio Núñez +2 more
doaj +1 more source
Role of the Calcium Plateau in the Neuronal Injury and Behavioral Morbidities Following Organophosphate Intoxication [PDF]
, 2016 Organophosphate (OP) chemicals include nerve agents and pesticides, and there is a growing concern of OP based chemical attacks against civilians. Current antidotes are essential in limiting immediate mortality associated with OP exposure.
Battaglia F.P. +8 more
core +2 more sources
TMEM16A controls EGF-induced calcium signaling implicated in pancreatic cancer prognosis
Proceedings of the National Academy of Sciences of the United States of America, 2019 Significance Cancer of the pancreas is highly heterogeneous. Improvement of diagnosis and prognosis requires the discovery of new biomarkers and new methods of classification.
D. Crottès +6 more
semanticscholar +1 more source
X-ROS Signaling Depends on Length-Dependent Calcium Buffering by Troponin
Cells, 2021 The stretching of a cardiomyocyte leads to the increased production of reactive oxygen species that increases ryanodine receptor open probability through a process termed X-ROS signaling.
Sarita Limbu +4 more
doaj +1 more source
Calcium Signaling in Brain Cancers: Roles and Therapeutic Targeting
Cancers, 2019 Calcium signaling, in addition to its numerous physiological roles, is also implicated in several pathological conditions including cancer. An increasing body of evidence suggest critical roles of calcium signaling in the promotion of different aspects ...
Ahmed S. Maklad, Anjana Sharma, I. Azimi
semanticscholar +1 more source
CIB1 protects against MPTP-induced neurotoxicity through inhibiting ASK1. [PDF]
, 2017 Calcium and integrin binding protein 1 (CIB1) is a calcium-binding protein that was initially identified as a binding partner of platelet integrin αIIb. Although CIB1 has been shown to interact with multiple proteins, its biological function in the brain
Choi, Eui-Ju +8 more
core +4 more sources
Mitochondrial dysfunctions trigger the calcium signaling-dependent fungal multidrug resistance
Proceedings of the National Academy of Sciences of the United States of America, 2019 Significance Millions of people with weakened immune systems are at a higher risk of developing different types of aspergillosis, whereas azole antifungals are the bedrock of therapy for these fungal infected diseases.
Yeqi Li +6 more
semanticscholar +1 more source
Calcium signalling in T cells [PDF]
Nature Reviews Immunology, 2019 Calcium (Ca2+) signalling is of paramount importance to immunity. Regulated increases in cytosolic and organellar Ca2+ concentrations in lymphocytes control complex and crucial effector functions such as metabolism, proliferation, differentiation, antibody and cytokine secretion and cytotoxicity.
Mohamed Trebak, Jean-Pierre Kinet
openaire +3 more sources
Amyloid pathology disrupts gliotransmitter release in astrocytes.
PLoS Computational Biology, 2022 Accumulation of amyloid-beta (Aβ) is associated with synaptic dysfunction and destabilization of astrocytic calcium homeostasis. A growing body of evidence support astrocytes as active modulators of synaptic transmission via calcium-mediated ...
Anup Gopalakrishna Pillai +1 more
doaj +1 more source
TMEM110 regulates the maintenance and remodeling of mammalian ER–plasma membrane junctions competent for STIM–ORAI signaling [PDF]
, 2015 The stromal interaction molecule (STIM)–ORAI calcium release-activated calcium modulator (ORAI) pathway controls store-dependent calcium entry, a major mechanism of physiological calcium signaling in mammalian cells.
Farber-Katz, Suzette +8 more
core +2 more sources