Results 81 to 90 of about 26,870 (178)

Leveraging the ADAM10 prodomain for selective inhibition to enhance recovery after myocardial infarction

British Journal of Pharmacology, Volume 183, Issue 5, Page 990-1008, March 2026.
Background and Purpose Inflammation plays a crucial role in the development and progression of numerous acute and chronic diseases such as myocardial infarction (MI) and heart failure. Targeting ADAM proteases, particularly ADAM10, holds promise for fine‐tuning inflammatory responses.
Erik Klapproth, Johanna Marks, Patrick Diaba‐Nuhoho, Sören Grell, Paul Leubauer, Susanne Kämmerer, Johannes R. Soltwedel, Fred Rasmussen, Felix Mejia, Marcia L. Moss, Christopher Prince, Peter Mirtschink, Ben Wielockx, Paul Saftig, Michael Wagner, Kristina Lorenz, Ali El‐Armouche   +16 more
wiley   +1 more source

Treg cells retain stable lineage commitment during pregnancy in mice after late gestation inflammatory challenge

Immunology &Cell Biology, Volume 104, Issue 3, Page 276-311, March 2026.
In this study, we used Foxp3‐fatemapping mice to examine the cell lineage stability of Treg cells in pregnancy. Ex‐Foxp3 cells were identified in gestational tissues. However, Treg cells retained lineage stability with no increased ex‐Foxp3 generation, regardless of inflammatory challenges that induce preterm birth.
Kerrie L Foyle, Ella S Green, Jessie R Walker‐Rogers, Ha M Tran, David M Olson, Lachlan M Moldenhauer, Sarah A Robertson   +6 more
wiley   +1 more source

Calpain-2 mediates SARS-CoV-2 entry via regulating ACE2 levels

mBio
Since the beginning of the coronavirus disease 2019 (COVID-19) pandemic, much effort has been dedicated to identifying effective antivirals against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2).
Qiru Zeng, Avan Antia, Luis Alberto Casorla-Perez, Maritza Puray-Chavez, Sebla B. Kutluay, Matthew A. Ciorba, Siyuan Ding   +6 more
doaj   +1 more source

Calcium Dysregulation Promotes Glioma Progression by Inhibiting STAT3 Degradation Through Blocking Chaperone‐Mediated Autophagy

Journal of Cellular and Molecular Medicine, Volume 30, Issue 5, March 2026.
ABSTRACT Calcium dysregulation is closely associated with cancer cell proliferation, migration, and invasion. Transient receptor potential canonical 1 (TRPC1) plays an essential role in regulating calcium homeostasis. However, the role of TRPC1 in calcium dysregulation in gliomas remains incompletely understood. In this study, we demonstrate that TRPC1
Jialong Chen, Yixi Lai, Mingque Li, ZiWei Cai, Renjian Lu, Linhua Liu, Yongming Peng, Chunlai Fu, Zhefan Xie, Xueqion Zhou, Jiaxian Liu, He Zhang   +11 more
wiley   +1 more source

Proton pump inhibitors modulate esophageal epithelial barrier function and crosstalk with eosinophils

Pediatric Allergy and Immunology, Volume 37, Issue 3, March 2026.
Abstract Background Eosinophilic esophagitis (EoE) is a chronic allergic disorder driven by type 2 inflammation, characterized by eosinophilic infiltration and esophageal epithelial abnormalities, including barrier dysfunction, basal cell hyperplasia, epithelial thickening, and loss of differentiation.
Ravi Gautam, Megha Lal, Margaret C. Carroll, Zoe Mrozek, Tina Trachsel, Jarad Beers, Melanie A. Ruffner   +6 more
wiley   +1 more source

Transport‐related effects on intrinsic and synaptic properties of human cortical neurons: A comparative study

The Journal of Physiology, Volume 604, Issue 5, Page 2060-2082, 1 March 2026.
Abstract figure legend In this study, we investigated how transporting brain slices influences the electrophysiological and morphological properties of human cortical neurons. Whole‐cell patch‐clamp recordings were obtained from acute slices prepared from tissue collected during epilepsy or tumor surgeries, either on‐site or off‐site, after ...
Guanxiao Qi, Danqing Yang, Aniella Bak, Werner Hucko, Daniel Delev, Hussam Hamou, Dirk Feldmeyer, Henner Koch   +7 more
wiley   +1 more source

Revisiting the calpain hypothesis of learning and memory 40 years later

Frontiers in Molecular Neuroscience
In 1984, Gary Lynch and Michel Baudry published in Science a novel biochemical hypothesis for learning and memory, in which they postulated that the calcium-dependent protease, calpain, played a critical role in regulating synaptic properties and the ...
Michel Baudry, Xiaoning Bi
doaj   +1 more source

Deciphering of the reactive oxygen species (ROS) induced calpain activation in cancer progression and its therapeutic potential

Advances in Redox Research
Mitochondrial signalling plays a fundamental role in orchestrating essential intracellular functions, including cellular respiration, proliferation, nucleic acid synthesis, and oxidative stress management.
Krishna Samanta, Ivan Ahel, Pulak Kar
doaj   +1 more source

Role of Calpain in Apoptosis [PDF]

Cell Journal, 2011
Apoptosis, a form of programmed cell death that occurs under physiologicalas well as pathological conditions, is characterized by morphological and biochemicalfeatures.
Hamid Reza Momeni
doaj  

Neuroprotective strategies against calpain-mediated neurodegeneration

Neuropsychiatric Disease and Treatment, 2015
Aysegul Yildiz-Unal,1 Sirin Korulu,2 Arzu Karabay3 1Department of Molecular Biology and Genetics, Faculty of Science, Mugla Sitki Koçman University, Kötekli, Mugla, Turkey; 2Department of Molecular Biology and Genetics, Istanbul Arel ...
Yildiz-Unal A, Korulu S, Karabay A
doaj