Results 1 to 10 of about 14,823 (146)
Integrative Metabolomics and Systems Pharmacology Reveal PPARγ-Centered Antidiabetic Mechanisms of Caulerpa racemosa and Its Bioactive Compounds [PDF]
Marine DrugsType 2 diabetes mellitus (T2DM) is a complex metabolic disorder requiring safe, multitarget therapeutic strategies. Marine macroalgae represent an underexplored source of bioactives with pleiotropic metabolic effects.
Fahrul Nurkolis +11 more
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Disruption of Endoplasmic Reticulum and ROS Production in Human Ovarian Cancer by Campesterol
Antioxidants, 2021 Phytosterols, which are present in a variety of foods, exhibit various physiological functions and do not have any side effects. Here, we attempted to identify functional role of campesterol in regulation of oxidative stress by leading to cell death of ...
Hyocheol Bae +4 more
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Phytosterols: From Preclinical Evidence to Potential Clinical Applications
Frontiers in Pharmacology, 2021 Phytosterols (PSs) are plant-originated steroids. Over 250 PSs have been isolated, and each plant species contains a characteristic phytosterol composition.
Bahare Salehi +18 more
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Frontiers in Environmental Science, 2022 Phytoremediation is gaining interest in recent years as it is a simple and effective strategy for heavy metal decontamination. The most straightforward strategy for successful heavy metal clean-up is searching for efficient hyperaccumulator species that ...
Ekta Bhattacharya, Suparna Mandal Biswas
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Engineering Yarrowia lipolytica for Campesterol Overproduction. [PDF]
PLoS ONE, 2016 Campesterol is an important precursor for many sterol drugs, e.g. progesterone and hydrocortisone. In order to produce campesterol in Yarrowia lipolytica, C-22 desaturase encoding gene ERG5 was disrupted and the heterologous 7-dehydrocholesterol ...
Hao-Xing Du +6 more
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Engineering of Saccharomyces cerevisiae for 24-Methylene-Cholesterol Production
Biomolecules, 2021 24-Methylene-cholesterol is a necessary substrate for the biosynthesis of physalin and withanolide, which show promising anticancer activities. It is difficult and costly to prepare 24-methylene-cholesterol via total chemical synthesis. In this study, we
Jiao Yang, Changfu Li, Yansheng Zhang
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Molecules, 2021 Cannabis sativa L. has been used for a long time to obtain food, fiber, and as a medicinal and psychoactive plant. Today, the nutraceutical potential of C.sativa is being increasingly reappraised; however, C.
Fabio Ferrini +7 more
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Plants, 2023 The prevalence of benign prostatic hyperplasia (BPH) markedly increases with age. Phytotherapeutic approaches have been developed over time owing to the adverse side effects of conventional medications such as 5-reductase inhibitors and α1-adrenergic ...
Mădălina-Georgiana Buț +6 more
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Steroid and fatty acid contents from the leaves of Carica papaya [PDF]
Folia Medica, 2021 Aim: To extract and identify the non-polar entities from the leaves of Carica papaya, a plant used for medicinal purpose as folk medicine.Materials and methods: Petroleum ether extract of the Carica papaya leaves was used for this study.
Vishvraj V. Devmurari +9 more
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Diatoms synthesize sterols by inclusion of animal and fungal genes in the plant pathway [PDF]
, 2020 Diatoms are ubiquitous microalgae that have developed remarkable metabolic plasticity and gene diversification. Here we report the first elucidation of the complete biosynthesis of sterols in the lineage.
, Angela +7 more
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