Results 31 to 40 of about 6,660,257 (317)

Neck and capsid architecture of the robust Agrobacterium phage Milano

Communications Biology, 2023
Large gaps exist in our understanding of how bacteriophages, the most abundant biological entities on Earth, assemble and function. The structure of the “neck” region, where the DNA-filled capsid is connected to the host-recognizing tail remains poorly ...
Ravi R. Sonani, Nathaniel C. Esteves, Abigail A. Horton, Rebecca J. Kelly, Amanda L. Sebastian, Fengbin Wang, Mark A. B. Kreutzberger, Petr G. Leiman, Birgit E. Scharf, Edward H. Egelman   +9 more
doaj   +1 more source

Iodination of Poliovirus Capsid Proteins

Journal of General Virology, 1977
Summary Iodination of the surface of poliovirus and its artificial empty capsid demonstrated predominant labelling of polypeptide VP 1 on the intact particle and an increased labelling of polypeptide VP 2 on the artificial empty capsid.
T W, Beneke, K O, Habermehl, W, Diefenthal, M, Buchholz   +3 more
openaire   +2 more sources

Adeno‐associated virus serotype 2 capsid variants for improved liver‐directed gene therapy

Hepatology, EarlyView., 2022
Abstract Background and Aims Current liver‐directed gene therapies look for adeno‐associated virus (AAV) vectors with improved efficacy. With this background, capsid engineering is explored. Whereas shuffled capsid library screenings have resulted in potent liver targeting variants with one first vector in human clinical trials, modifying natural ...
Nadja Meumann, Marti Cabanes‐Creus, Moritz Ertelt, Renina Gale Navarro, Julie Lucifora, Qinggong Yuan, Karin Nien‐Huber, Ahmed Abdelrahman, Xuan‐Khang Vu, Liang Zhang, Ann‐Christin Franke, Christian Schmithals, Albrecht Piiper, Annabelle Vogt, Maria Gonzalez‐Carmona, Jochen T. Frueh, Evelyn Ullrich, Philip Meuleman, Steven R. Talbot, Margarete Odenthal, Michael Ott, Erhard Seifried, Clara T. Schoeder, Joachim Schwäble, Leszek Lisowski, Hildegard Büning   +25 more
wiley   +1 more source

A novel capsid protein network allows the characteristic internal membrane structure of Marseilleviridae giant viruses

Scientific Reports, 2022
Marseilleviridae is a family of giant viruses, showing a characteristic internal membrane with extrusions underneath the icosahedral vertices. However, such large objects, with a maximum diameter of 250 nm are technically difficult to examine at sub ...
Akane Chihara, Raymond N. Burton-Smith, Naoko Kajimura, Kaoru Mitsuoka, Kenta Okamoto, Chihong Song, Kazuyoshi Murata   +6 more
doaj   +1 more source

Osmotic pressure: resisting or promoting DNA ejection from phage [PDF]

, 2008
Recent in vitro experiments have shown that DNA ejection from bacteriophage can be partially stopped by surrounding osmotic pressure when ejected DNA is digested by DNase I on the course of ejection.
Castelnovo, Martin, Evilevitch, Alex,, Jeembaeva, Meerim,, Larsson, Frida, Lund University.   +4 more
core   +3 more sources

The Assembly-Activating Protein Promotes Stability and Interactions between AAV's Viral Proteins to Nucleate Capsid Assembly.

Cell Reports, 2018
The adeno-associated virus (AAV) vector is a preferred delivery platform for in vivo gene therapy. Natural and engineered variations of the AAV capsid affect a plurality of phenotypes relevant to gene therapy, including vector production and host tropism.
Anna C. Maurer, Simon Pacouret, Ana Karla Cepeda Diaz, J. Blake, Eva Andrés-Mateos, L. Vandenberghe   +5 more
semanticscholar   +1 more source

Multifaceted Capsid Proteins: Multiple Interactions Suggest Multiple Roles for Pepino mosaic virus Capsid Protein [PDF]

Molecular Plant-Microbe Interactions®, 2014
Pepino mosaic virus (PepMV) (family Alphaflexiviridae, genus Potexvirus) is a mechanically transmitted tomato pathogen that, over the last decade, has evolved from emerging to endemic worldwide. Here, two heat-shock cognate (Hsc70) isoforms were identified as part of the coat protein (CP)/Hsc70 complex in vivo, following full-length PepMV and CP ...
Matthaios M. Mathioudakis, Luis Rodríguez-Moreno, Raquel Navarro Sempere, Miguel A. Aranda, Ioannis Livieratos   +4 more
openaire   +3 more sources

Protein chainmail variants in dsDNA viruses. [PDF]

, 2015
First discovered in bacteriophage HK97, biological chainmail is a highly stable system formed by concatenated protein rings. Each subunit of the ring contains the HK97-like fold, which is characterized by its submarine-like shape with a 5-stranded β ...
Chiou, Joshua, Zhou, Z Hong
core   +2 more sources

Nuclear restriction of HIV-1 infection by SUN1

Scientific Reports, 2021
Overexpression of the human Sad-1-Unc-84 homology protein 2 (SUN2) blocks HIV-1 infection in a capsid-dependent manner. In agreement, we showed that overexpression of SUN1 (Sad1 and UNC-84a) also blocks HIV-1 infection in a capsid-dependent manner.
Mirjana Persaud, Anastasia Selyutina, Cindy Buffone, Silvana Opp, Daniel A. Donahue, Oliver Schwartz, Felipe Diaz-Griffero   +6 more
doaj   +1 more source

Visualizing HIV-1 Capsid and Its Interactions with Antivirals and Host Factors

Viruses, 2021
Understanding of the construction and function of the HIV capsid has advanced considerably in the last decade. This is due in large part to the development of more sophisticated structural techniques, particularly cryo-electron microscopy (cryoEM) and ...
Morganne Wilbourne, Peijun Zhang
doaj   +1 more source