Results 31 to 40 of about 5,586,089 (360)
Neck and capsid architecture of the robust Agrobacterium phage Milano
Communications Biology, 2023 Large gaps exist in our understanding of how bacteriophages, the most abundant biological entities on Earth, assemble and function. The structure of the “neck” region, where the DNA-filled capsid is connected to the host-recognizing tail remains poorly ...
Ravi R. Sonani +9 more
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The capsid protein of human immunodeficiency virus: designing inhibitors of capsid assembly [PDF]
The FEBS Journal, 2009 The mature capsid of human immunodeficiency virus, HIV‐1, is formed by the assembly of copies of a capsid protein (CA). The C‐terminal domain of CA, CTD, is able to homodimerize and most of the dimerization interface is formed by a single α‐helix from each monomer.
José L. Neira, José L. Neira
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Structure, Function, and Interactions of the HIV-1 Capsid Protein
Life, 2021 The capsid (CA) protein of the human immunodeficiency virus type 1 (HIV-1) is an essential structural component of a virion and facilitates many crucial life cycle steps through interactions with host cell factors.
E. Rossi +3 more
semanticscholar +1 more source
Viruses, 2014 To get access to the replication site, small non-enveloped DNA viruses have to cross the cell membrane using a limited number of capsid proteins, which also protect the viral genome in the extracellular environment.
Eva Bilkova +2 more
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Visualizing HIV-1 Capsid and Its Interactions with Antivirals and Host Factors
Viruses, 2021 Understanding of the construction and function of the HIV capsid has advanced considerably in the last decade. This is due in large part to the development of more sophisticated structural techniques, particularly cryo-electron microscopy (cryoEM) and ...
Morganne Wilbourne, Peijun Zhang
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Role of electrostatic interactions in the assembly of empty spherical viral capsids [PDF]
Phys. Rev. E 76, 061906 (2007), 2007 We examine the role of electrostatic interactions in the assembly of empty spherical viral capsids. The charges on the protein subunits that make the viral capsid mutually interact and are expected to yield electrostatic repulsion acting against the assembly of capsids.
arxiv +1 more source
Three-Dimensional Localization of the Smallest Capsid Protein in the Human Cytomegalovirus Capsid [PDF]
Journal of Virology, 2005 ABSTRACT The smallest capsid proteins (SCPs) of the human herpesviruses differ substantially in size and sequence and are thought to impart some unique aspects of infection to their respective viruses. We used electron cryomicroscopy and antibody labeling to show that the 8-kDa SCP of human cytomegalovirus is attached only to major capsid ...
Fenyong Liu +6 more
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Nuclear restriction of HIV-1 infection by SUN1
Scientific Reports, 2021 Overexpression of the human Sad-1-Unc-84 homology protein 2 (SUN2) blocks HIV-1 infection in a capsid-dependent manner. In agreement, we showed that overexpression of SUN1 (Sad1 and UNC-84a) also blocks HIV-1 infection in a capsid-dependent manner.
Mirjana Persaud +6 more
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The Impact of Capsid Proteins on Virus Removal and Inactivation During Water Treatment Processes
Microbiology Insights, 2015 This study examined the effect of the amino acid composition of protein capsids on virus inactivation using ultraviolet (UV) irradiation and titanium dioxide photocatalysis, and physical removal via enhanced coagulation using ferric chloride.
Brooke K. Mayer +3 more
semanticscholar +1 more source
Role of Genome in the Formation of Conical Retroviral Shells [PDF]
J. Phys. Chem. B 120, 6298 (2016), 2016 Human immunodeficiency virus (HIV) capsid proteins spontaneously assemble around the genome into a protective protein shell called the capsid, which can take on a variety of shapes broadly classified as conical, cylindrical and irregular. The majority of capsids seen in in vivo studies are conical in shape, while in vitro experiments have shown a ...
arxiv +1 more source